Tbio SHISA9 Protein shisa-9

Protein Summary

Description

Regulator of short-term neuronal synaptic plasticity in the dentate gyrus. Associates with AMPA receptors (ionotropic glutamate receptors) in synaptic spines and promotes AMPA receptor desensitization at excitatory synapses (By similarity).

Uniprot Accession IDs

• B4DS77
• C9J314
• C9JCE9

Gene Name

• SHISA9

Ensembl ID

• ENST00000423335
• ENSP00000395245
• ENSG00000237515
• ENST00000558583
• ENSP00000454014

Symbol

• CKAMP44

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
microRNA	0.98
phenotype	0.77
trait	0.75
disease	0.73
tissue sample	0.72

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.75   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 70   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.75   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 70   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0