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Tbio
B3GNT2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

Protein Summary
Description
Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine. Catalyzes the initiation and elongation of poly-N-acetyllactosamine chains. Shows a marked preference for Gal(beta1-4)Glc(NAc)-based acceptors (PubMed:9892646). Probably constitutes the main polylactosamine synthase. This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase family. This enzyme is a type II transmembrane protein. It prefers the substrate of lacto-N-neotetraose, and is involved in the biosynthesis of poly-N-acetyllactosamine chains. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000301998
  • ENSP00000305595
  • ENSG00000170340
  • ENST00000405767
  • ENSP00000384692

Symbol
  • B3GALT7
  • B3GNT1
  • B3GNT
  • BGNT2
  • B3GNT1
  • BGnT-2
  • beta-1
  • 3-Gn-T1
  • 3-Gn-T2
  • B3GN-T2
  • B3GNT-2
  • BETA3GNT
  • beta3Gn-T1
  • beta3Gn-T2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
transcription factor binding site profile
0.88
pathway
0.84
tissue sample
0.74
transcription factor
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.11   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 161   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.11   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 161   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0