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Tbio
B3GNT2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

Protein Summary
Description
Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine. Catalyzes the initiation and elongation of poly-N-acetyllactosamine chains. Shows a marked preference for Gal(beta1-4)Glc(NAc)-based acceptors (PubMed:9892646). Probably constitutes the main polylactosamine synthase. This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase family. This enzyme is a type II transmembrane protein. It prefers the substrate of lacto-N-neotetraose, and is involved in the biosynthesis of poly-N-acetyllactosamine chains. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000301998
  • ENSP00000305595
  • ENSG00000170340
  • ENST00000405767
  • ENSP00000384692

Symbol
  • B3GALT7
  • B3GNT1
  • B3GNT
  • BGNT2
  • B3GNT1
  • BGnT-2
  • beta-1
  • 3-Gn-T1
  • 3-Gn-T2
  • B3GN-T2
  • B3GNT-2
  • BETA3GNT
  • beta3Gn-T1
  • beta3Gn-T2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
transcription factor binding site profile
0.88
pathway
0.84
tissue sample
0.74
transcription factor
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.62   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 161   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.62   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 161   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (105)
CDK3
Tchem
Family:  Kinase
Novelty:  0.03380289
p_int:  0.999852773
p_ni:  0.000147227
Data Source:  BioPlex
C1GALT1C1
Tbio
Family:  Enzyme
Novelty:  0.01318017
p_int:  0.997098763
p_ni:  0.002901237
Score:  0.635
Data Source:  BioPlex,STRINGDB
CIB2
Tbio
Novelty:  0.03578691
p_int:  0.995187188
p_ni:  0.004812675
p_wrong:  1.36e-7
Data Source:  BioPlex
CD79B
Tclin
Novelty:  0.00227414
p_int:  0.995083118
p_ni:  0.004916865
p_wrong:  1.7e-8
Data Source:  BioPlex
FAM3C
Tbio
Novelty:  0.04598347
p_int:  0.994769789
p_ni:  0.005229844
p_wrong:  3.67e-7
Score:  0.174
Data Source:  BioPlex,STRINGDB
ARMC6
Tdark
Novelty:  0.58706267
p_int:  0.990519786
p_ni:  0.009480214
Data Source:  BioPlex
Q8NFQ8
Tbio
Novelty:  0.08912351
p_int:  0.983256433
p_ni:  0.016743567
Data Source:  BioPlex
NRG1
Tbio
Novelty:  0.00095246
p_int:  0.974691001
p_ni:  0.025308895
p_wrong:  1.05e-7
Data Source:  BioPlex
LCN6
Tbio
Novelty:  0.11406686
p_int:  0.973355891
p_ni:  0.025717207
p_wrong:  0.000926902
Data Source:  BioPlex
TUBA4A
Tchem
Novelty:  0.00820546
p_int:  0.970746123
p_ni:  0.029253877
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (15)
Glycosaminoglycan metabolism (R-HSA-1630316)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycosaminoglycan metabolism
Reactome
Keratan sulfate biosynthesis
Reactome
Keratan sulfate/keratin metabolism
Reactome
Metabolism
Reactome
Metabolism of carbohydrates
Name
Explore in Pharos
Explore in Source
Glycosaminoglycan metabolism
Keratan sulfate biosynthesis
Keratan sulfate/keratin metabolism
Metabolism
Metabolism of carbohydrates
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (14)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Disease Associations ()
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
2
2
79.7
mean corpuscular hemoglobin concentration
2
2
2
71
testosterone measurement
2
3
3
63.1
erythrocyte count
1
2
2
55.1
mean corpuscular volume
3
2
3
55.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
2
79.7
mean corpuscular hemoglobin concentration
2
71
testosterone measurement
3
63.1
erythrocyte count
2
55.1
mean corpuscular volume
3
55.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
693396
Mouse
MGI:1889505
53625
Rat
RGD:1310077
305571
Dog
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
VGNC:38341
474611
Horse
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
VGNC:15731
100064405
Species
Name
OMA
EggNOG
Inparanoid
Macaque
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
Mouse
Rat
Dog
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
Horse
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
Publication Statistics
PubMed Score 39.62
PubMed score by year
PubTator Score 784.53
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title