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Tbio
B3GALT5
Beta-1,3-galactosyltransferase 5

Protein Summary
Description
Catalyzes the transfer of Gal to GlcNAc-based acceptors with a preference for the core3 O-linked glycan GlcNAc(beta1,3)GalNAc structure. Can use glycolipid LC3Cer as an efficient acceptor. This gene encodes a member of a family of membrane-bound glycoproteins. The encoded protein may synthesize type 1 Lewis antigens, which are elevated in gastrointestinal and pancreatic cancers. Alternatively spliced transcript variants using multiple alternate promoters have been observed for this gene. [provided by RefSeq, Sep 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000343118
  • ENSP00000343318
  • ENSG00000183778
  • ENST00000380618
  • ENSP00000369992
  • ENST00000380620
  • ENSP00000369994
  • ENST00000615480
  • ENSP00000480285

Symbol
  • B3T5
  • GLCT5
  • B3GalTx
  • B3GalT-V
  • beta3Gal-T5
  • beta-3-Gx-T5
  • beta-1,3-GalTase 5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.71
cell type or tissue
0.65
disease perturbation
0.62
metabolite
0.62
tissue sample
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.51   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 99   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.51   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 99   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0