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Tbio
B3GALT2
Beta-1,3-galactosyltransferase 2

Protein Summary
Description
Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-N-acetylglucosamine (beta-GlcNAc) residue. Can also utilize substrates with a terminal galactose residue, albeit with lower efficiency. Involved in the biosynthesis of the carbohydrate moieties of glycolipids and glycoproteins. Inactive towards substrates with terminal alpha-N-acetylglucosamine (alpha-GlcNAc) or alpha-N-acetylgalactosamine (alpha-GalNAc) residues. This gene is a member of the beta-1,3-galactosyltransferase (beta3GalT) gene family. This family encodes type II membrane-bound glycoproteins with diverse enzymatic functions using different donor substrates (UDP-galactose and UDP-N-acetylglucosamine) and different acceptor sugars (N-acetylglucosamine, galactose, N-acetylgalactosamine). The beta3GalT genes are distantly related to the Drosophila Brainiac gene and have the protein coding sequence contained in a single exon. The beta3GalT proteins also contain conserved ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367434
  • ENSP00000356404
  • ENSG00000162630

Symbol
  • GLCT2
  • BETA3GALT2
  • beta3Gal-T2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.91
microRNA
0.75
cell type or tissue
0.7
gene perturbation
0.68
trait
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.21   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 148   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.21   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 148   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (48)
GNPTAB
Tbio
Family:  Enzyme
Novelty:  0.00336101
p_int:  0.99868125
p_ni:  0.001318749
p_wrong:  1e-9
Score:  0.232
Data Source:  BioPlex,STRINGDB
TMEM259
Tbio
Novelty:  0.10015777
p_int:  0.908442107
p_ni:  0.091557893
Score:  0.232
Data Source:  BioPlex,STRINGDB
IPO13
Tbio
Novelty:  0.01954093
p_int:  0.878639494
p_ni:  0.121360506
Score:  0.241
Data Source:  BioPlex,STRINGDB
LRP5
Tbio
Novelty:  0.00089807
p_int:  0.865124942
p_ni:  0.122617801
p_wrong:  0.012257257
Score:  0.173
Data Source:  BioPlex,STRINGDB
LTN1
Tbio
Family:  Enzyme
Novelty:  0.02604262
p_int:  0.787177755
p_ni:  0.212822245
Score:  0.19
Data Source:  BioPlex,STRINGDB
B4GALT1
Tbio
Family:  Enzyme
Novelty:  0.0073693
Score:  0.953
Data Source:  STRINGDB
B4GALT4
Tbio
Family:  Enzyme
Novelty:  0.11226614
Score:  0.932
Data Source:  STRINGDB
FUT1
Tbio
Family:  Enzyme
Novelty:  0.00597206
Score:  0.931
Data Source:  STRINGDB
FUT2
Tbio
Family:  Enzyme
Novelty:  0.0009286
Score:  0.921
Data Source:  STRINGDB
B4GALT2
Tbio
Family:  Enzyme
Novelty:  0.03492512
Score:  0.92
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Blood group systems biosynthesis (R-HSA-9033658)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Blood group systems biosynthesis
Reactome
Lewis blood group biosynthesis
Reactome
Metabolism
Reactome
Metabolism of carbohydrates
Name
Explore in Pharos
Explore in Source
Blood group systems biosynthesis
Lewis blood group biosynthesis
Metabolism
Metabolism of carbohydrates
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
educational attainment
1
1
1
42.1
lifestyle measurement
1
1
1
36.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
educational attainment
1
42.1
lifestyle measurement
1
36.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
beta-1,3-galactosyltransferase 2
712334
Mouse
MGI:1349461
26878
Rat
RGD:1586615
686081
Dog
beta-1,3-galactosyltransferase 2
VGNC:38334
607356
Horse
beta-1,3-galactosyltransferase 2
VGNC:15725
100051213
Species
Name
OMA
EggNOG
Inparanoid
Macaque
beta-1,3-galactosyltransferase 2
Mouse
Rat
Dog
beta-1,3-galactosyltransferase 2
Horse
beta-1,3-galactosyltransferase 2
Publication Statistics
PubMed Score 6.21
PubMed score by year
PubTator Score 1.00
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title