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Tdark
BTBD18
BTB/POZ domain-containing protein 18

Protein Summary
Description
Specifically required during spermatogenesis to promote expression of piRNA precursors. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons, which is essential for the germline integrity. Acts by facilitating transcription elongation at piRNA loci during pachytene.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000422652
  • ENSP00000394472
  • ENSG00000233436
  • ENST00000436147
  • ENSP00000397020
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.65
cellular component
0.64
tissue sample
0.57
virus perturbation
0.5
small molecule perturbation
0.46


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.71   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 13   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.71   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 13   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (7)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (8)
1 – 8 of 8
KLHL28
Tdark
Score: 0.571
Data Source: STRINGDB
TNRC18
Tdark
Novelty: 1.1559633
Score: 0.495
Data Source: STRINGDB
ZBTB3
Tdark
Family: TF
Novelty: 0.33381503
Score: 0.483
Data Source: STRINGDB
BTBD3
Tdark
Novelty: 0.2303263
Score: 0.473
Data Source: STRINGDB
GMCL1
Tbio
Novelty: 0.1349742
Score: 0.473
Data Source: STRINGDB
MLLT6
Tdark
Family: Epigenetic
Novelty: 0.04069948
Score: 0.427
Data Source: STRINGDB
NACC2
Tbio
Novelty: 0.01121795
Score: 0.409
Data Source: STRINGDB
MLLT10
Tbio
Family: Epigenetic
Novelty: 0.00736155
Score: 0.405
Data Source: STRINGDB
Publication Statistics
PubMed Score  2.71

PubMed score by year
PubTator Score  1.5

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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