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Tdark
BTBD18
BTB/POZ domain-containing protein 18

Protein Summary
Description
Specifically required during spermatogenesis to promote expression of piRNA precursors. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons, which is essential for the germline integrity. Acts by facilitating transcription elongation at piRNA loci during pachytene.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000422652
  • ENSP00000394472
  • ENSG00000233436
  • ENST00000436147
  • ENSP00000397020
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.65
cellular component
0.64
tissue sample
0.57
virus perturbation
0.5
small molecule perturbation
0.46


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.51   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 13   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.51   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 13   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
4
3
4
91
neuroticism measurement
5
4
3
6.5
76.7
mean corpuscular hemoglobin concentration
1
1
1
75.2
wellbeing measurement
3
3
3
73.2
self reported educational attainment
1
1
1
69.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
4
91
neuroticism measurement
3
6.5
76.7
mean corpuscular hemoglobin concentration
1
75.2
wellbeing measurement
3
73.2
self reported educational attainment
1
69.5
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
BTB domain containing 18
VGNC:53054
748220
Rat
RGD:2323370
100363270
Dog
BTB domain containing 18
VGNC:38550
100688289
Cow
BTB domain containing 18 [Source:HGNC Symbol;Acc:HGNC:37214]
Pig
BTB domain containing 18 [Source:HGNC Symbol;Acc:HGNC:37214]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
BTB domain containing 18
Rat
Dog
BTB domain containing 18
Cow
BTB domain containing 18 [Source:HGNC Symbol;Acc:HGNC:37214]
Pig
BTB domain containing 18 [Source:HGNC Symbol;Acc:HGNC:37214]
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-B2RXH4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (7)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (8)
1 – 8 of 8
KLHL28
Tdark
Novelty:  1.1777024
Score:  0.571
Data Source:  STRINGDB
TNRC18
Tdark
Novelty:  0.32654022
Score:  0.495
Data Source:  STRINGDB
ZBTB3
Tdark
Family:  TF
Novelty:  0.34423886
Score:  0.483
Data Source:  STRINGDB
BTBD3
Tbio
Novelty:  0.16338626
Score:  0.473
Data Source:  STRINGDB
GMCL1
Tbio
Novelty:  0.1543762
Score:  0.473
Data Source:  STRINGDB
MLLT6
Tdark
Family:  Epigenetic
Novelty:  0.03728427
Score:  0.427
Data Source:  STRINGDB
NACC2
Tbio
Novelty:  0.03937051
Score:  0.409
Data Source:  STRINGDB
MLLT10
Tbio
Family:  Epigenetic
Novelty:  0.00590548
Score:  0.405
Data Source:  STRINGDB
Publication Statistics
PubMed Score  3.51

PubMed score by year
PubTator Score  1.5

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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