Tchem KDM4E Lysine-specific demethylase 4E

Protein Summary

Description

Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. The protein encoded by this intronless gene is a member of a large family of histone lysine demethylases, which use oxygen and 2-oxoglutarate to demethylate di- and trimethylated lys9 of histone H3. Derepression of genes by demethylases is sometimes involved in viral infection or carcinogenesis, so inhibitors of these enzymes are desired. [provided by RefSeq, Dec 2016]

Uniprot Accession IDs

• B2RXH2

Gene Name

• KDM4E

Ensembl ID

• ENST00000450979
• ENSP00000397239
• ENSG00000235268

Symbol

• KDM4DL
• KDM5E
• JMJD2E
• KDM4DL

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell line	0.57
biological process	0.46
tissue	0.46
cellular component	0.36
biological term	0.33

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Zinc Finger Transcription Factor / Lysine-specific Demethylase 4e

DTO Classes

Protein / Epigenetic Regulator / Eraser / Lysine Demethylase / Jumonji Domain-containing / Lysine-specific Demethylase 4e

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.08   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 32   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.08   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 32   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 19

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0