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Tchem
KDM4E
Lysine-specific demethylase 4E

Protein Summary
Description
Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. The protein encoded by this intronless gene is a member of a large family of histone lysine demethylases, which use oxygen and 2-oxoglutarate to demethylate di- and trimethylated lys9 of histone H3. Derepression of genes by demethylases is sometimes involved in viral infection or carcinogenesis, so inhibitors of these enzymes are desired. [provided by RefSeq, Dec 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000450979
  • ENSP00000397239
  • ENSG00000235268

Symbol
  • KDM4DL
  • KDM5E
  • JMJD2E
  • KDM4DL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.57
biological process
0.46
tissue
0.46
cellular component
0.36
biological term
0.33


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.73   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 32   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.73   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 32   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 18
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (18)
CHEMBL3786952
Rendered image for CHEMBL3786952
2,4-pyridine dicarboxylic acid
Rendered image for 2,4-pyridine dicarboxylic acid
IOX1
Rendered image for IOX1
CHEMBL3108958
Rendered image for CHEMBL3108958
CHEMBL3770740
Rendered image for CHEMBL3770740
CHEMBL3771180,CHEMBL3771198
Rendered image for CHEMBL3771180,CHEMBL3771198
CHEMBL3769724
Rendered image for CHEMBL3769724
3-(Benzylamino)isonicotinic Acid
Rendered image for 3-(Benzylamino)isonicotinic Acid
Protein-Protein Interactions (31)
KDM2A
Tchem
Family:  Epigenetic
Novelty:  0.01990727
Score:  0.716
Data Source:  STRINGDB
PHF8
Tchem
Family:  Epigenetic
Novelty:  0.01946151
Score:  0.682
Data Source:  STRINGDB
KDM6B
Tchem
Family:  Epigenetic
Novelty:  0.0048959
Score:  0.675
Data Source:  STRINGDB
CWC15
Tbio
Novelty:  0.00205068
Score:  0.673
Data Source:  STRINGDB
PXMP4
Tbio
Novelty:  0.22622548
Score:  0.667
Data Source:  STRINGDB
CATSPER2
Tchem
Family:  IC
Novelty:  0.03701031
Score:  0.64
Data Source:  STRINGDB
KDM7A
Tchem
Family:  Epigenetic
Novelty:  0.04113733
Score:  0.637
Data Source:  STRINGDB
KDM1A
Tchem
Family:  Epigenetic
Novelty:  0.00142673
Score:  0.617
Data Source:  STRINGDB
PHF2
Tbio
Family:  Epigenetic
Novelty:  0.10427439
Score:  0.61
Data Source:  STRINGDB
KDM3A
Tchem
Family:  Epigenetic
Novelty:  0.0101705
Score:  0.591
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
3
3
96.1
reticulocyte count
2
1
2
59
platelet count
1
1
1
48.5
reticulocyte measurement
1
1
1
40.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
96.1
reticulocyte count
2
59
platelet count
1
48.5
reticulocyte measurement
1
40.7
IDG Resources
No IDG generated resources found
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
lysine demethylase 4E
VGNC:11865
466755
Species
Name
OMA
EggNOG
Inparanoid
Chimp
lysine demethylase 4E
Publication Statistics
PubMed Score 13.73
PubMed score by year
PubTator Score 8.88
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title