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Tbio
ZBTB42
Zinc finger and BTB domain-containing protein 42

Protein Summary
Description
Transcriptional repressor. Specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. The protein encoded by this gene is a member of the C2H2 zinc finger protein family. This protein is predicted to have a pox virus and zinc finger (POZ) domain at the N-terminus and four zinc finger domains at the C-terminus. In human and mouse, the protein localizes to the nuclei of skeletal muscle cells. Knockdown of this gene in zebrafish results in abnormal skeletal muscle development and myofibrillar disorganization. A novel homozygous variant of the human gene has been associated with lethal congenital contracture syndrome, an autosomal recessive disorder that results in muscle wasting. [provided by RefSeq, Mar 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000342537
  • ENSP00000409107
  • ENSG00000179627
  • ENST00000555360
  • ENSP00000450673

Symbol
  • LCCS6
  • ZNF925
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
tissue sample
0.64
cell type or tissue
0.56
histone modification site profile
0.53
biological process
0.52


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.17   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 72   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.17   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 72   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
5
2
6
61
sex hormone-binding globulin measurement
2
1
2
35.1
testosterone measurement
1
1
1
19.6
alcohol drinking
1
1
2
3.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
6
61
sex hormone-binding globulin measurement
2
35.1
testosterone measurement
1
19.6
alcohol drinking
2
3.9
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger and BTB domain containing 42
467569
Macaque
zinc finger and BTB domain containing 42
706991
Mouse
MGI:3644133
382639
Rat
RGD:1582758
691556
Cow
zinc finger and BTB domain containing 42
VGNC:37081
789062
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger and BTB domain containing 42
Macaque
zinc finger and BTB domain containing 42
Mouse
Rat
Cow
zinc finger and BTB domain containing 42
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-B2RXF5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (17)
1 – 10 of 17
ZBTB18
Tbio
Family: TF
Novelty: 0.03802355
p_int: 0.999999996
p_wrong: 4e-9
Score: 0.188
Data Source: BioPlex,STRINGDB
PRMT9
Tbio
Family: Enzyme
Novelty: 0.26898134
p_int: 0.999999682
p_ni: 2.84e-7
p_wrong: 3.4e-8
Score: 0.209
Data Source: BioPlex,STRINGDB
FBXL17
Tbio
Novelty: 0.16122137
p_int: 0.999999656
p_ni: 3.44e-7
Score: 0.221
Data Source: BioPlex,STRINGDB
VRK1
Tbio
Family: Kinase
Novelty: 0.00761136
p_int: 0.999993392
p_ni: 0.000006608
Score: 0.232
Data Source: BioPlex,STRINGDB
RNF187
Tbio
Family: Enzyme
Novelty: 0.13506464
p_int: 0.999946935
p_ni: 0.000053061
p_wrong: 5e-9
Score: 0.219
Data Source: BioPlex,STRINGDB
MID1
Tbio
Family: Enzyme
Novelty: 0.02400169
p_int: 0.999851663
p_ni: 0.000148337
Score: 0.22
Data Source: BioPlex,STRINGDB
ZNF516
Tbio
Family: TF
Novelty: 0.22650006
p_int: 0.976918077
p_ni: 0.023080592
p_wrong: 0.000001331
Score: 0.209
Data Source: BioPlex,STRINGDB
CTBP2
Tchem
Novelty: 0.00538964
p_int: 0.948344385
p_ni: 0.05165557
p_wrong: 4.5e-8
Score: 0.221
Data Source: BioPlex,STRINGDB
ZPR1
Tbio
Novelty: 0.01893839
p_int: 0.921245465
p_ni: 0.078753668
p_wrong: 8.68e-7
Score: 0.187
Data Source: BioPlex,STRINGDB
GGPS1
Tchem
Family: Enzyme
Novelty: 0.00292258
p_int: 0.875202167
p_ni: 0.124797833
Data Source: BioPlex
Publication Statistics
PubMed Score  2.17

PubMed score by year
PubTator Score  2.14

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer