Tbio B2M Beta-2-microglobulin

Protein Summary

Description

Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Exogenously applied M.tuberculosis EsxA or EsxA-EsxB (or EsxA expressed in host) binds B2M and decreases its export to the cell surface (total protein levels do not change), probably leading to defects in class I antigen presentation (PubMed:25356553). This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. The encoded antimicrobial protein displays antibacterial activity in amniotic fluid. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.[provided by RefSeq, Aug 2014]

Uniprot Accession IDs

• P61769
• P01884
• Q540F8
• Q6IAT8
• Q9UCK0
• Q9UD48
• Q9UDF4

Gene Name

• B2M

Ensembl ID

• ENST00000558401
• ENSP00000452780
• ENSG00000166710
• ENST00000559916
• ENSP00000453350
• ENST00000561424
• ENSP00000453191
• ENST00000617605
• ENSP00000481426
• ENSG00000273686
• ENST00000631573
• ENSP00000488548
• ENST00000631728
• ENSP00000488321
• ENST00000648006
• ENSP00000497910

Symbol

• IMD43

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	1
disease perturbation	1
virus perturbation	1
kinase perturbation	0.99
transcription factor perturbation	0.94

Protein Classes

PANTHER Classes

Protein / Defense/immunity Protein / Major Histocompatibility Complex Antigen / Beta-2-microglobulin

DTO Classes

Protein / Immune Response / Major Histocompatibility Complex Antigen / Beta-2-microglobulin

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8021.16   (req: < 5)

Gene RIFs: 262   (req: <= 3)

Antibodies: 2183   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8021.16   (req: >= 5)

Gene RIFs: 262   (req: > 3)

Antibodies: 2183   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 39

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (504)

Explore Interacting Targets

1 – 10 of 504

• See Interactions on String-DB

RGPD2

Tdark

Novelty:  0.02695062

p_int:  0.999999975

p_ni:  6e-9

p_wrong:  1.9e-8

Score:  0.552

Data Source:  BioPlex,STRINGDB

FCGRT

Tclin

Novelty:  0.00105713

p_int:  0.999999467

p_ni:  5.33e-7

Score:  0.963

Data Source:  BioPlex,STRINGDB

RGPD5

Tbio

Novelty:  0.13776125

p_int:  0.99999784

p_ni:  0.00000216

Data Source:  BioPlex

DLGAP5

Tbio

Novelty:  0.01673312

p_int:  0.99998432

p_ni:  0.00001566

p_wrong:  2e-8

Score:  0.524

Data Source:  BioPlex,STRINGDB

TPST1

Tbio

Family:  Enzyme

Novelty:  0.03915379

p_int:  0.999839163

p_ni:  0.000122084

p_wrong:  0.000038753

Score:  0.19

Data Source:  BioPlex,STRINGDB

RANBP2

Tbio

Family:  Enzyme

Novelty:  0.00484823

p_int:  0.999805914

p_ni:  0.000194086

Score:  0.815

Data Source:  BioPlex,STRINGDB

RANGAP1

Tbio

Family:  Enzyme

Novelty:  0.00917672

p_int:  0.99862759

p_ni:  0.00137241

Score:  0.827

Data Source:  BioPlex,STRINGDB

CD1E

Tbio

Novelty:  0.00171622

p_int:  0.990978394

p_ni:  0.009021497

p_wrong:  1.09e-7

Score:  0.795

Data Source:  BioPlex,STRINGDB

KPNA4

Tbio

Novelty:  0.01326511

p_int:  0.981971745

p_ni:  0.018028255

Score:  0.183

Data Source:  BioPlex,STRINGDB

CDCA2

Tbio

Novelty:  0.04666018

p_int:  0.976364702

p_ni:  0.021044365

p_wrong:  0.002590932

Score:  0.183

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (33)

Reactome (24)

KEGG (6)

PathwayCommons (3)

Adaptive Immune System (R-HSA-1280218)

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Items per page:

5

1 – 5 of 24

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Adaptive Immune System	894 targets	R-HSA-1280218
Reactome	Amyloid fiber formation	79 targets	R-HSA-977225
Reactome	Antigen Presentation: Folding, assembly and peptide loading of class I MHC	92 targets	R-HSA-983170
Reactome	Antigen processing-Cross presentation	169 targets	R-HSA-1236975
Reactome	Class I MHC mediated antigen processing & presentation	437 targets	R-HSA-983169

Name	Explore in Pharos	Explore in Source
Adaptive Immune System	894 targets	R-HSA-1280218
Amyloid fiber formation	79 targets	R-HSA-977225
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	92 targets	R-HSA-983170
Antigen processing-Cross presentation	169 targets	R-HSA-1236975
Class I MHC mediated antigen processing & presentation	437 targets	R-HSA-983169

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (59)

Functions (1)

Components (20)

Processes (38)

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Items per page:

10

1 – 1 of 1

GO Term	Evidence	Assigned by
identical protein binding	Inferred from Physical Interaction (IPI)	IntAct

Disease Associations (null)

No disease associations found

GWAS Traits (3)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 3 of 3

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
high density lipoprotein cholesterol measurement	EFO_0004612	1	1	1		79.5
apolipoprotein A 1 measurement	EFO_0004614	1	1	1		72.6
sex hormone-binding globulin measurement	EFO_0004696	4	1	4		62.6

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 3 of 3

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
high density lipoprotein cholesterol measurement	EFO_0004612	1		79.5
apolipoprotein A 1 measurement	EFO_0004614	1		72.6
sex hormone-binding globulin measurement	EFO_0004696	4		62.6

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Amyloid
Amyloidosis
Complete proteome
Direct protein sequencing
Disease mutation
Disulfide bond
Glycation
Glycoprotein
Immunity

GWAS Trait Find Similar Targets

No Header	No Header
apolipoprotein A 1 measurement
high density lipoprotein cholesterol measurement
sex hormone-binding globulin measurement

MGI Phenotype Find Similar Targets

No Header	No Header
endocrine/exocrine gland phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
immune system phenotype
mortality/aging
nervous system phenotype

IDG Resources

No IDG generated resources found

Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	beta-2-microglobulin	VGNC:11825	450170
Macaque	beta-2-microglobulin		712428
Mouse	beta-2 microglobulin	MGI:88127	12010
Rat	beta-2 microglobulin	RGD:2189	24223
Dog	beta-2-microglobulin	VGNC:38331	100855741

Species	Name	OMA	EggNOG	Inparanoid
Chimp	beta-2-microglobulin
Macaque	beta-2-microglobulin
Mouse	beta-2 microglobulin
Rat	beta-2 microglobulin
Dog	beta-2-microglobulin

Publication Statistics

PubMed Score 8021.16

PubMed score by year

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PubTator Score 6607.69

PubTator score by year

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Related Publications

Text Mined References (351)

GeneRif Annotations (262)

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10

0 of 0

PMID	Year	Title