Protein Summary
Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Exogenously applied M.tuberculosis EsxA or EsxA-EsxB (or EsxA expressed in host) binds B2M and decreases its export to the cell surface (total protein levels do not change), probably leading to defects in class I antigen presentation (PubMed:25356553). This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. The encoded antimicrobial protein displays antibacterial activity in amniotic fluid. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.[provided by RefSeq, Aug 2014]
- ENST00000558401
- ENSP00000452780
- ENSG00000166710
- ENST00000559916
- ENSP00000453350
- ENST00000561424
- ENSP00000453191
- ENST00000617605
- ENSP00000481426
- ENSG00000273686
- ENST00000631573
- ENSP00000488548
- ENST00000631728
- ENSP00000488321
- ENST00000648006
- ENSP00000497910
- IMD43
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological term | 1 | ||
disease perturbation | 1 | ||
virus perturbation | 1 | ||
kinase perturbation | 0.99 | ||
transcription factor perturbation | 0.94 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 8021.16 (req: < 5)
Gene RIFs: 262 (req: <= 3)
Antibodies: 2183 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 8021.16 (req: >= 5)
Gene RIFs: 262 (req: > 3)
Antibodies: 2183 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 39
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (504)
RGPD2
Novelty: 0.02695062
p_int: 0.999999975
p_ni: 6e-9
p_wrong: 1.9e-8
Score: 0.552
Data Source: BioPlex,STRINGDB
FCGRT
Novelty: 0.00105713
p_int: 0.999999467
p_ni: 5.33e-7
Score: 0.963
Data Source: BioPlex,STRINGDB
DLGAP5
Novelty: 0.01673312
p_int: 0.99998432
p_ni: 0.00001566
p_wrong: 2e-8
Score: 0.524
Data Source: BioPlex,STRINGDB
TPST1
Family: Enzyme
Novelty: 0.03915379
p_int: 0.999839163
p_ni: 0.000122084
p_wrong: 0.000038753
Score: 0.19
Data Source: BioPlex,STRINGDB
RANBP2
Family: Enzyme
Novelty: 0.00484823
p_int: 0.999805914
p_ni: 0.000194086
Score: 0.815
Data Source: BioPlex,STRINGDB
RANGAP1
Family: Enzyme
Novelty: 0.00917672
p_int: 0.99862759
p_ni: 0.00137241
Score: 0.827
Data Source: BioPlex,STRINGDB
CD1E
Novelty: 0.00171622
p_int: 0.990978394
p_ni: 0.009021497
p_wrong: 1.09e-7
Score: 0.795
Data Source: BioPlex,STRINGDB
KPNA4
Novelty: 0.01326511
p_int: 0.981971745
p_ni: 0.018028255
Score: 0.183
Data Source: BioPlex,STRINGDB
CDCA2
Novelty: 0.04666018
p_int: 0.976364702
p_ni: 0.021044365
p_wrong: 0.002590932
Score: 0.183
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (33)
Reactome (24)
KEGG (6)
PathwayCommons (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Adaptive Immune System | ||||
Reactome | Amyloid fiber formation | ||||
Reactome | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | ||||
Reactome | Antigen processing-Cross presentation | ||||
Reactome | Class I MHC mediated antigen processing & presentation | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Adaptive Immune System | ||||
Amyloid fiber formation | ||||
Antigen Presentation: Folding, assembly and peptide loading of class I MHC | ||||
Antigen processing-Cross presentation | ||||
Class I MHC mediated antigen processing & presentation | ||||
Viral Interactions (0)
Gene Ontology Terms (59)
Functions (1)
Components (20)
Processes (38)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Physical Interaction (IPI) | IntAct | |||
Disease Associations ()
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
high density lipoprotein cholesterol measurement | 1 | 1 | 1 | 79.5 | |||||
apolipoprotein A 1 measurement | 1 | 1 | 1 | 72.6 | |||||
sex hormone-binding globulin measurement | 4 | 1 | 4 | 62.6 | |||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
high density lipoprotein cholesterol measurement | 1 | 79.5 | |||||
apolipoprotein A 1 measurement | 1 | 72.6 | |||||
sex hormone-binding globulin measurement | 4 | 62.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | beta-2-microglobulin | VGNC:11825 | 450170 | |||||
Macaque | beta-2-microglobulin | 712428 | ||||||
Mouse | MGI:88127 | 12010 | ||||||
Rat | RGD:2189 | 24223 | ||||||
Dog | beta-2-microglobulin | VGNC:38331 | 100855741 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | beta-2-microglobulin | |||||
Macaque | beta-2-microglobulin | |||||
Mouse | ||||||
Rat | ||||||
Dog | beta-2-microglobulin | |||||
Publication Statistics
PubMed Score 8021.16
PubMed score by year
PubTator Score 6607.69
PubTator score by year
Related Publications
Text Mined References (351)
GeneRif Annotations (262)
Items per page:
0 of 0
PMID | Year | Title |
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