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Tbio
KLLN
Killin

Protein Summary
Description
DNA-binding protein involved in S phase checkpoint control-coupled apoptosis by mediating p53/TP53-induced apoptosis. Has the ability to inhibit DNA synthesis and S phase arrest coupled to apoptosis. Has affinity to both double- and single-stranded DNA. The protein encoded by this intronless gene is found in the nucleus, where it can inhibit DNA synthesis and promote S phase arrest coupled to apoptosis. The expression of this DNA binding protein is upregulated by transcription factor p53. [provided by RefSeq, Dec 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000445946
  • ENSP00000392204
  • ENSG00000227268
  • ENST00000635224
  • ENSP00000489239
  • ENSG00000283059
  • ENST00000644082
  • ENSP00000495113

Symbol
  • CWS4
  • KILLIN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.73
tissue sample
0.62
transcription factor binding site profile
0.53
cell line
0.52
phenotype
0.52


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.23   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 117   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.23   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 117   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (46)
Items per page:
1 – 5 of 46
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
4
4
96.7
eosinophil count
3
4
4
96.7
eosinophil percentage of leukocytes
2
2
2
89.5
eosinophil percentage of leukocytes
2
2
2
89.5
neutrophil count
2
2
2
88.2
Items per page:
1 – 5 of 46
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
4
96.7
eosinophil count
4
96.7
eosinophil percentage of leukocytes
2
89.5
eosinophil percentage of leukocytes
2
89.5
neutrophil count
2
88.2
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
killin, p53 regulated DNA replication inhibitor
VGNC:51979
100610121
Species
Name
OMA
EggNOG
Inparanoid
Chimp
killin, p53 regulated DNA replication inhibitor
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-B2CW77-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (5)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (11)
1 – 10 of 11
FLCN
Tbio
Novelty:  0.0022007
Score:  0.729
Data Source:  STRINGDB
GLRX
Tbio
Novelty:  0.00111903
Score:  0.638
Data Source:  STRINGDB
PGAP1
Tbio
Family:  Enzyme
Novelty:  0.04642526
Score:  0.633
Data Source:  STRINGDB
NELFB
Tbio
Novelty:  0.05821821
Score:  0.631
Data Source:  STRINGDB
KIF18B
Tbio
Novelty:  0.06496349
Score:  0.607
Data Source:  STRINGDB
PTEN
Tchem
Family:  Enzyme
Novelty:  0.00013818
Score:  0.551
Data Source:  STRINGDB
SDHB
Tchem
Family:  Enzyme
Novelty:  0.0010199
Score:  0.474
Data Source:  STRINGDB
PRF1
Tchem
Novelty:  0.0002835
Score:  0.453
Data Source:  STRINGDB
SDHD
Tbio
Family:  Enzyme
Novelty:  0.00167904
Score:  0.412
Data Source:  STRINGDB
GDPGP1
Tbio
Family:  Enzyme
Novelty:  0.01138425
Score:  0.406
Data Source:  STRINGDB
Publication Statistics
PubMed Score  23.23

PubMed score by year
PubTator Score  12.68

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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