You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
HACD1
Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 1

Protein Summary
Description
Isoform 1: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Isoform 2: In tooth development, may play a role in the recruitment and the differentiation of cells that contribute to cementum formation. May also bind hydroxyapatite and regulate its crystal nucleation to form cementum. The protein encoded by this gene contains a characteristic catalytic motif of the protein tyrosine phosphatases (PTPs) family. The PTP motif of this protein has the highly conserved argi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361271
  • ENSP00000355308
  • ENSG00000165996

Symbol
  • PTPLA
  • CAP
  • PTPLA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.98
histone modification site profile
0.9
transcription factor perturbation
0.88
PubMedID
0.64
tissue sample
0.55


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.02   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 61   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.02   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 61   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (42)
SEMG1
Tbio
Novelty:  0.0161449
p_int:  0.999950756
p_ni:  0.000049244
Score:  0.295
Data Source:  BioPlex,STRINGDB
SEMG2
Tbio
Novelty:  0.06325799
p_int:  0.999649453
p_ni:  0.000350547
Score:  0.513
Data Source:  BioPlex,STRINGDB
SLC15A1
Tchem
Family:  Transporter
Novelty:  0.00149723
p_int:  0.995579607
p_ni:  0.001530202
p_wrong:  0.00289019
Data Source:  BioPlex
EDEM2
Tbio
Family:  Enzyme
Novelty:  0.1180208
p_int:  0.993833641
p_ni:  0.00172065
p_wrong:  0.004445709
Score:  0.177
Data Source:  BioPlex,STRINGDB
TECR
Tbio
Family:  Enzyme
Novelty:  0.00114749
Score:  0.973
Data Source:  STRINGDB
HSD17B12
Tbio
Family:  Enzyme
Novelty:  0.02200219
Score:  0.971
Data Source:  STRINGDB
CEMP1
Tbio
Novelty:  0.01532189
Score:  0.831
Data Source:  STRINGDB
MTM1
Tbio
Family:  Enzyme
Novelty:  0.00413329
Score:  0.75
Data Source:  STRINGDB
PTS
Tbio
Family:  Enzyme
Novelty:  0.00279396
Score:  0.736
Data Source:  STRINGDB
MTMR7
Tbio
Family:  Enzyme
Novelty:  0.1707096
Score:  0.634
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Fatty acid metabolism (R-HSA-8978868)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Fatty acid metabolism
Reactome
Fatty acyl-CoA biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Synthesis of very long-chain fatty acyl-CoAs
Name
Explore in Pharos
Explore in Source
Fatty acid metabolism
Fatty acyl-CoA biosynthesis
Metabolism
Metabolism of lipids
Synthesis of very long-chain fatty acyl-CoAs
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (19)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
3-hydroxyacyl-CoA dehydratase 1
VGNC:9744
450331
Macaque
3-hydroxyacyl-CoA dehydratase 1
700635
Mouse
MGI:1353592
30963
Dog
3-hydroxyacyl-CoA dehydratase 1
VGNC:52135
574011
Horse
3-hydroxyacyl-CoA dehydratase 1
VGNC:18677
100068422
Species
Name
OMA
EggNOG
Inparanoid
Chimp
3-hydroxyacyl-CoA dehydratase 1
Macaque
3-hydroxyacyl-CoA dehydratase 1
Mouse
Dog
3-hydroxyacyl-CoA dehydratase 1
Horse
3-hydroxyacyl-CoA dehydratase 1
Publication Statistics
PubMed Score 42.02
PubMed score by year
PubTator Score 21.21
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Text