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Tbio
MYO1G
Unconventional myosin-Ig

Protein Summary
Description
Unconventional myosin required during immune response for detection of rare antigen-presenting cells by regulating T-cell migration. Unconventional myosins are actin-based motor molecules with ATPase activity and serve in intracellular movements. Acts as a regulator of T-cell migration by generating membrane tension, enforcing cell-intrinsic meandering search, thereby enhancing detection of rare antigens during lymph-node surveillance, enabling pathogen eradication. Also required in B-cells, where it regulates different membrane/cytoskeleton-dependent processes. Involved in Fc-gamma receptor (Fc-gamma-R) phagocytosis. Minor histocompatibility antigen HA-2: Constitutes the minor histocompatibility antigen HA-2. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by nor ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000258787
  • ENSP00000258787
  • ENSG00000136286

Symbol
  • HA2
  • HA2
  • MHAG
  • HLA-HA2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
molecular function
0.99
cell type or tissue
0.68
PubMedID
0.65
tissue sample
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 97.77   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 72   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 97.77   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 72   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (106)
1 – 10 of 106
AHRR
Tbio
Family:  TF
Novelty:  0.01361231
Score:  0.775
Data Source:  STRINGDB
ANKRD9
Tdark
Novelty:  0.43181793
Score:  0.735
Data Source:  STRINGDB
MARCH3
Tbio
Family:  Enzyme
Novelty:  0.12529817
Score:  0.724
Data Source:  STRINGDB
CHEK2
Tchem
Family:  Kinase
Novelty:  0.00068355
Score:  0.723
Data Source:  STRINGDB
FLYWCH1
Tdark
Novelty:  0.45235856
Score:  0.719
Data Source:  STRINGDB
CENPM
Tbio
Novelty:  0.0671332
Score:  0.71
Data Source:  STRINGDB
GFI1
Tbio
Family:  TF
Novelty:  0.00466154
Score:  0.701
Data Source:  STRINGDB
RALA
Tbio
Family:  Enzyme
Novelty:  0.00257914
Score:  0.666
Data Source:  STRINGDB
AKTIP
Tbio
Novelty:  0.00315951
Score:  0.666
Data Source:  STRINGDB
ARHGAP45
Tbio
Novelty:  0.13518861
Score:  0.665
Data Source:  STRINGDB
Gene Ontology Terms (23)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
3
2
3
89.5
lymphocyte count
3
1
3
85.7
myeloid white cell count
2
1
2
85.2
leukocyte count
2
1
2
81.9
monocyte percentage of leukocytes
2
1
2
79.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
3
89.5
lymphocyte count
3
85.7
myeloid white cell count
2
85.2
leukocyte count
2
81.9
monocyte percentage of leukocytes
2
79.9
Find similar targets by:
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
myosin IG
VGNC:14051
463387
Macaque
myosin IG
698101
Mouse
MGI:1927091
246177
Rat
RGD:1306016
289785
Horse
myosin IG
VGNC:20504
100052077
Species
Name
OMA
EggNOG
Inparanoid
Chimp
myosin IG
Macaque
myosin IG
Mouse
Rat
Horse
myosin IG
Publication Statistics
PubMed Score 97.77
PubMed score by year
PubTator Score 51.25
PubTator score by year