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Tbio
AZU1
Azurocidin

Protein Summary
Description
This is a neutrophil granule-derived antibacterial and monocyte- and fibroblast-specific chemotactic glycoprotein. Binds heparin. The cytotoxic action is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. It may play a role in mediating recruitment of monocytes in the second wave of inflammation. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa. Acting alone, it does not have antimicrobial activity against the Gram-negative bacteria A.actinomycetemcomitans ATCC 29532, A.actinomycetemcomitans NCTC 9709, A.actinomycetemcomitans FDC-Y4, H.aphrophilus ATCC 13252, E.corrodens ATCC 23834, C.sputigena ATCC 33123, Capnocytophaga sp ATCC 33124, Capnocytophaga sp ATCC 27872 or E.coli ML-35. Has antibacterial activity agai ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000233997
  • ENSP00000233997
  • ENSG00000172232
  • ENST00000620695
  • ENSP00000479183
  • ENSG00000278624

Symbol
  • AZU
  • HBP
  • NAZC
  • hHBP
  • AZAMP
  • CAP37
  • HUMAZUR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.88
cellular component
0.68
molecular function
0.6
disease
0.53
tissue
0.52


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 357.37   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 271   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 357.37   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 271   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 33
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (137)
ERBIN
Tbio
Novelty:  0.01419561
p_int:  0.999997903
p_ni:  0.000002097
Score:  0.217
Data Source:  BioPlex,STRINGDB
CBWD3
Tdark
Novelty:  0.03639787
p_int:  0.999885322
p_ni:  0.000114511
p_wrong:  1.66e-7
Score:  0.155
Data Source:  BioPlex,STRINGDB
SH3GL1
Tbio
Novelty:  0.02379336
p_int:  0.999152966
p_ni:  0.000847034
Score:  0.588
Data Source:  BioPlex,STRINGDB
SH3GL2
Tbio
Novelty:  0.0188955
p_int:  0.995734962
p_ni:  0.004265016
p_wrong:  2.2e-8
Score:  0.689
Data Source:  BioPlex,STRINGDB
FIGNL1
Tbio
Family:  Enzyme
Novelty:  0.10817841
p_int:  0.995521152
p_ni:  0.000750513
p_wrong:  0.003728335
Score:  0.179
Data Source:  BioPlex,STRINGDB
ZYG11B
Tbio
Novelty:  0.14657862
p_int:  0.986137917
p_ni:  0.013862083
Data Source:  BioPlex
STAT3
Tchem
Family:  TF
Novelty:  0.00011808
p_int:  0.98275583
p_ni:  0.01724417
p_wrong:  1e-9
Score:  0.211
Data Source:  BioPlex,STRINGDB
FBXO2
Tbio
Novelty:  0.01578361
p_int:  0.941104385
p_ni:  0.058832445
p_wrong:  0.000063171
Data Source:  BioPlex
BIN3
Tbio
Novelty:  0.02034119
p_int:  0.901634957
p_ni:  0.002046316
p_wrong:  0.096318727
Score:  0.183
Data Source:  BioPlex,STRINGDB
DIEXF
Tbio
Novelty:  0.05892659
p_int:  0.889944162
p_ni:  0.005272976
p_wrong:  0.104782862
Score:  0.21
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (40)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
3
13
20
99.5
reticulocyte count
7
10
28
99.3
heel bone mineral density
3
4
6
94.5
serum gamma-glutamyl transferase measurement
2
2
3
93.1
hematocrit
2
2
3
93.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
20
99.5
reticulocyte count
28
99.3
heel bone mineral density
6
94.5
serum gamma-glutamyl transferase measurement
3
93.1
hematocrit
3
93.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
azurocidin 1
VGNC:10886
468636
Macaque
azurocidin 1
100425740
Cow
azurocidin 1
VGNC:26370
100336938
Pig
azurocidin 1
100522363
Species
Name
OMA
EggNOG
Inparanoid
Chimp
azurocidin 1
Macaque
azurocidin 1
Cow
azurocidin 1
Pig
azurocidin 1
Publication Statistics
PubMed Score 357.37
PubMed score by year
PubTator Score 186.53
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title