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Tbio
AZIN2
Antizyme inhibitor 2

Protein Summary
Description
Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme-binding (PubMed:17900240). Inhibits antizyme-dependent ODC degradation and releases ODC monomers from their inactive complex with antizymes, leading to formation of the catalytically active ODC homodimer and restoring polyamine production (PubMed:17900240). Participates in the morphological integrity of the trans-Golgi network (TGN) and functions as a regulator of intracellular secretory vesicle trafficking (PubMed:20188728). The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000294517
  • ENSP00000294517
  • ENSG00000142920
  • ENST00000373440
  • ENSP00000362539
  • ENST00000373441
  • ENSP00000362540
  • ENST00000373443
  • ENSP00000362542

Symbol
  • ADC
  • KIAA1945
  • ODCP
  • ADC
  • AZI2
  • ODCp
  • AZIB1
  • ODC-p
  • ODC1L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
cellular component
0.86
molecular function
0.79
biological process
0.66
tissue
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 125.05   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 65   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 125.05   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 65   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (59)
OAZ1
Tbio
Family:  Enzyme
Novelty:  0.0224953
p_int:  1
Score:  0.87
Data Source:  BioPlex,STRINGDB
OAZ2
Tbio
Family:  Enzyme
Novelty:  0.1687351
p_int:  0.999992282
p_wrong:  0.000007718
Score:  0.893
Data Source:  BioPlex,STRINGDB
CORO7
Tbio
Novelty:  0.14307384
p_int:  0.995885494
p_ni:  0.003568459
p_wrong:  0.000546046
Data Source:  BioPlex
PRAME
Tbio
Novelty:  0.00543263
p_int:  0.994400216
p_ni:  0.005599767
p_wrong:  1.7e-8
Score:  0.161
Data Source:  BioPlex,STRINGDB
TPD52L1
Tbio
Novelty:  0.04828057
p_int:  0.993770868
p_ni:  0.006224719
p_wrong:  0.000004413
Score:  0.326
Data Source:  BioPlex,STRINGDB
SMARCAL1
Tbio
Novelty:  0.01436868
p_int:  0.992649683
p_ni:  0.005942264
p_wrong:  0.001408052
Score:  0.318
Data Source:  BioPlex,STRINGDB
LRIF1
Tdark
Novelty:  0.26861958
p_int:  0.98618531
p_ni:  0.013814682
p_wrong:  8e-9
Score:  0.183
Data Source:  BioPlex,STRINGDB
DDX11
Tbio
Family:  Enzyme
Novelty:  0.02282234
p_int:  0.963186111
p_ni:  0.036792598
p_wrong:  0.000021291
Score:  0.209
Data Source:  BioPlex,STRINGDB
SMG8
Tdark
Novelty:  0.18080965
p_int:  0.814969932
p_ni:  0.185029938
p_wrong:  1.3e-7
Score:  0.181
Data Source:  BioPlex,STRINGDB
AGMAT
Tbio
Family:  Enzyme
Novelty:  0.03970349
Score:  0.993
Data Source:  STRINGDB
Pathways (8)
Agmatine biosynthesis (R-HSA-351143)

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Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Agmatine biosynthesis
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Reactome
Metabolism of polyamines
Name
Explore in Pharos
Explore in Source
Agmatine biosynthesis
Metabolism
Metabolism of amino acids and derivatives
Metabolism of polyamines
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
gut microbiome measurement
1
1
1
40.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
gut microbiome measurement
1
40.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
antizyme inhibitor 2
VGNC:10548
469170
Macaque
antizyme inhibitor 2
709823
Mouse
MGI:2442093
242669
Dog
antizyme inhibitor 2
VGNC:38330
478144
Horse
antizyme inhibitor 2
VGNC:50648
100070043
Species
Name
OMA
EggNOG
Inparanoid
Chimp
antizyme inhibitor 2
Macaque
antizyme inhibitor 2
Mouse
Dog
antizyme inhibitor 2
Horse
antizyme inhibitor 2
Publication Statistics
PubMed Score 125.05
PubMed score by year
PubTator Score 108.62
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title