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Tbio
AZIN1
Antizyme inhibitor 1

Protein Summary
Description
Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme-binding (PubMed:17900240, PubMed:26305948). Inhibits antizyme-dependent ODC degradation and releases ODC monomers from their inactive complex with antizymes, leading to formation of the catalytically active ODC homodimer and restoring polyamine production (PubMed:17900240). The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine; however, retain the ability to bind to antizymes. Antizymes negatively regulate intra ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000337198
  • ENSP00000337180
  • ENSG00000155096
  • ENST00000347770
  • ENSP00000321507

Symbol
  • OAZI
  • OAZIN
  • AZI
  • AZI1
  • OAZI
  • AZIA1
  • OAZIN
  • ODC1L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.97
protein domain
0.92
transcription factor perturbation
0.84
disease perturbation
0.79
kinase perturbation
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.18   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 153   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.18   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 153   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (81)
OAZ3
Tbio
Family:  Enzyme
Novelty:  0.02374168
p_int:  1
Score:  0.989
Data Source:  BioPlex,Reactome,STRINGDB
OAZ1
Tbio
Family:  Enzyme
Novelty:  0.0224953
p_int:  0.999999026
p_ni:  9.4e-7
p_wrong:  3.4e-8
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
KLC4
Tdark
Novelty:  0.32552746
p_int:  0.999779462
p_ni:  0.000220534
p_wrong:  4e-9
Score:  0.568
Data Source:  BioPlex,STRINGDB
OAZ2
Tbio
Family:  Enzyme
Novelty:  0.1687351
p_int:  0.999570924
p_ni:  9.9e-8
p_wrong:  0.000428977
Score:  0.992
Data Source:  BioPlex,Reactome,STRINGDB
KLC2
Tbio
Novelty:  0.06284367
p_int:  0.999323795
p_ni:  0.000676205
Score:  0.739
Data Source:  BioPlex,STRINGDB
KLC1
Tbio
Novelty:  0.00653484
p_int:  0.993605183
p_ni:  0.006394817
Score:  0.823
Data Source:  BioPlex,STRINGDB
TDP2
Tchem
Family:  Enzyme
Novelty:  0.01104303
p_int:  0.990138778
p_ni:  0.009834175
p_wrong:  0.000027046
Score:  0.316
Data Source:  BioPlex,STRINGDB
KIF5B
Tbio
Novelty:  0.00515256
p_int:  0.946192793
p_ni:  0.053807207
Score:  0.679
Data Source:  BioPlex,STRINGDB
KIF5C
Tbio
Novelty:  0.0238573
p_int:  0.812226671
p_ni:  0.187773329
Score:  0.719
Data Source:  BioPlex,STRINGDB
ODC1
Tclin
Family:  Enzyme
Novelty:  0.00037968
Score:  0.909
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Reactome
Metabolism of polyamines
Reactome
Regulation of ornithine decarboxylase (ODC)
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of amino acids and derivatives
Metabolism of polyamines
Regulation of ornithine decarboxylase (ODC)
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
3
3
3
89.7
leukocyte count
2
2
2
84.5
high density lipoprotein cholesterol measurement
2
2
2
79.6
reticulocyte measurement
1
1
1
72.5
alkaline phosphatase measurement
2
2
1
6.3
62.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
3
89.7
leukocyte count
2
84.5
high density lipoprotein cholesterol measurement
2
79.6
reticulocyte measurement
1
72.5
alkaline phosphatase measurement
1
6.3
62.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
antizyme inhibitor 1
VGNC:916
464324
Macaque
antizyme inhibitor 1
693581
Mouse
MGI:1859169
54375
Rat
RGD:61934
58961
Dog
antizyme inhibitor 1
VGNC:38329
475058
Species
Name
OMA
EggNOG
Inparanoid
Chimp
antizyme inhibitor 1
Macaque
antizyme inhibitor 1
Mouse
Rat
Dog
antizyme inhibitor 1
Publication Statistics
PubMed Score 35.18
PubMed score by year
PubTator Score 29.22
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title