You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
AZI2
5-azacytidine-induced protein 2

Protein Summary
Description
Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity. Activates serine/threonine-protein kinase TBK1 and facilitates its oligomerization. Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1. Promotes TBK1-induced as well as TNF-alpha or PMA-induced activation of NF-kappa-B. Participates in IFNB promoter activation via TICAM1. AZI2, or NAP1, contributes to the activation of NFKB (see MIM 164011)-dependent gene expression by activating IKK-related kinases, such as NAK (TBK1; MIM 604834) (Fujita et al., 2003 [PubMed 14560022]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000334100
  • ENSP00000335609
  • ENSG00000163512
  • ENST00000420543
  • ENSP00000391696
  • ENST00000457172
  • ENSP00000389577
  • ENST00000479665
  • ENSP00000419371

Symbol
  • NAP1
  • TBKBP2
  • AZ2
  • NAP1
  • TILP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
1
virus perturbation
1
transcription factor binding site profile
0.91
kinase perturbation
0.84
interacting protein
0.81


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.61   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 109   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.61   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 109   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (32)
BBOX1
Tchem
Family:  Enzyme
Novelty:  0.00255489
p_int:  0.999999707
p_ni:  2.93e-7
Score:  0.237
Data Source:  BioPlex,STRINGDB
APBA3
Tbio
Novelty:  0.05059532
p_int:  0.999999434
p_ni:  5.64e-7
p_wrong:  2e-9
Score:  0.189
Data Source:  BioPlex,STRINGDB
CALCOCO2
Tbio
Novelty:  0.01456844
p_int:  0.999998792
p_ni:  3.2e-8
p_wrong:  0.000001176
Score:  0.706
Data Source:  BioPlex,STRINGDB
PIP
Tbio
Novelty:  0.00208509
p_int:  0.999998601
p_ni:  0.000001398
Data Source:  BioPlex
IRAK3
Tchem
Family:  Kinase
Novelty:  0.01001206
p_int:  0.987415372
p_ni:  0.000576863
p_wrong:  0.012007764
Score:  0.189
Data Source:  BioPlex,STRINGDB
TBK1
Tchem
Family:  Kinase
Novelty:  0.00194753
Score:  0.999
Data Source:  STRINGDB
IKBKE
Tchem
Family:  Kinase
Novelty:  0.01447079
Score:  0.945
Data Source:  STRINGDB
TANK
Tbio
Novelty:  0.01003866
Score:  0.906
Data Source:  STRINGDB
TBKBP1
Tbio
Family:  Enzyme
Novelty:  0.11778482
Score:  0.901
Data Source:  STRINGDB
IKBKG
Tbio
Family:  Kinase
Novelty:  0.0006149
Score:  0.85
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
5
5
5
96
lymphocyte percentage of leukocytes
2
2
2
89.6
red blood cell distribution width
1
1
1
45.7
monocyte percentage of leukocytes
1
1
1
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
5
96
lymphocyte percentage of leukocytes
2
89.6
red blood cell distribution width
1
45.7
monocyte percentage of leukocytes
1
35
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
5-azacytidine induced 2
VGNC:5034
460239
Macaque
5-azacytidine induced 2
705275
Mouse
MGI:1351332
27215
Rat
RGD:1310530
316051
Dog
5-azacytidine induced 2
VGNC:38328
485632
Species
Name
OMA
EggNOG
Inparanoid
Chimp
5-azacytidine induced 2
Macaque
5-azacytidine induced 2
Mouse
Rat
Dog
5-azacytidine induced 2
Publication Statistics
PubMed Score 5.61
PubMed score by year
PubTator Score 7.54
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title