Tchem AXIN2 Axin-2

Protein Summary

Description

Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B (By similarity). The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9Y2T1
• Q3MJ88
• Q9H3M6
• Q9UH84

Gene Name

• AXIN2

Ensembl ID

• ENST00000307078
• ENSP00000302625
• ENSG00000168646

Symbol

• AXIL
• ODCRCS

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.99
transcription factor perturbation	0.96
PubMedID	0.85
transcription factor binding site profile	0.82
cellular component	0.75

Protein Classes

DTO Classes

Leukocyte Cell-derived Chemotaxin-2 / Ataxin-2 / Ataxin-2-like Protein / Syntaxin-2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 420.14   (req: < 5)

Gene RIFs: 114   (req: <= 3)

Antibodies: 290   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 420.14   (req: >= 5)

Gene RIFs: 114   (req: > 3)

Antibodies: 290   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0