You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
AWAT2
Acyl-CoA wax alcohol acyltransferase 2

Protein Summary
Description
Acyltransferase that predominantly esterify long chain (wax) alcohols with acyl-CoA-derived fatty acids to produce wax esters. Wax esters are enriched in sebum, suggesting that it plays a central role in lipid metabolism in skin. Has no activity using decyl alcohol and significantly prefers the C16 and C18 alcohols. May also have 2-acylglycerol O-acyltransferase (MGAT) and acyl-CoA:retinol acyltransferase (ARAT) activities, to catalyze the synthesis of diacylglycerols and retinyl esters; however this activity is unclear in vivo. This gene encodes an enzyme belonging to the diacylglycerol acyltransferase family. This enzyme produces wax esters by the esterification of long chain (or wax) alcohols with acyl-CoA-derived fatty acids. It functions in lipid metabolism in the skin, mostly in undifferentiated peripheral sebocytes. This enzyme may also have acyl-CoA:retinol acyltransferase activities, where it catalyzes the synthesis of diacylglycerols and retinyl esters. [provided by RefSeq, M ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000276101
  • ENSP00000421172
  • ENSG00000147160

Symbol
  • DC4
  • DGAT2L4
  • MFAT
  • WS
  • WS
  • DC4
  • ARAT
  • MFAT
  • DGAT2L4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
metabolite
0.83
cell type or tissue
0.54
microRNA
0.47
tissue
0.42
cell line
0.41


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 105.58   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 95   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 105.58   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 95   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (46)
DGAT1
Tclin
Family:  Enzyme
Novelty:  0.00121009
Score:  0.929
Data Source:  STRINGDB
RLBP1
Tbio
Novelty:  0.00526176
Score:  0.922
Data Source:  Reactome,STRINGDB
RPE65
Tbio
Family:  Enzyme
Novelty:  0.00147985
Score:  0.911
Data Source:  STRINGDB
DHRS4
Tbio
Family:  Enzyme
Novelty:  0.02992279
Score:  0.905
Data Source:  STRINGDB
DHRS3
Tbio
Family:  Enzyme
Novelty:  0.04448013
Score:  0.904
Data Source:  STRINGDB
RDH11
Tbio
Family:  Enzyme
Novelty:  0.02758936
Score:  0.904
Data Source:  STRINGDB
RDH10
Tbio
Family:  Enzyme
Novelty:  0.03049914
Score:  0.904
Data Source:  STRINGDB
SDR16C5
Tbio
Family:  Enzyme
Novelty:  0.11319496
Score:  0.904
Data Source:  STRINGDB
RETSAT
Tdark
Family:  Enzyme
Novelty:  0.10624626
Score:  0.903
Data Source:  STRINGDB
CYP26A1
Tchem
Family:  Enzyme
Novelty:  0.00281805
Score:  0.901
Data Source:  STRINGDB
Pathways (32)
Acyl chain remodeling of DAG and TAG (R-HSA-1482883)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Acyl chain remodeling of DAG and TAG
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
Glycerophospholipid biosynthesis
Reactome
Metabolism
Name
Explore in Pharos
Explore in Source
Acyl chain remodeling of DAG and TAG
G alpha (i) signalling events
GPCR downstream signalling
Glycerophospholipid biosynthesis
Metabolism
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (10)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Experiment (EXP)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
acyl-CoA wax alcohol acyltransferase 2
VGNC:1428
473654
Mouse
MGI:3045345
245532
Rat
RGD:1565111
302425
Dog
acyl-CoA wax alcohol acyltransferase 2
VGNC:38322
491936
Horse
acyl-CoA wax alcohol acyltransferase 2
VGNC:15714
100066473
Species
Name
OMA
EggNOG
Inparanoid
Chimp
acyl-CoA wax alcohol acyltransferase 2
Mouse
Rat
Dog
acyl-CoA wax alcohol acyltransferase 2
Horse
acyl-CoA wax alcohol acyltransferase 2
Publication Statistics
PubMed Score 105.58
PubMed score by year
PubTator Score 17.78
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title