Protein Summary
Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption. This gene encodes the vasopressin receptor, type 2, also known as the V2 receptor, which belongs to the seven-transmembrane-domain G protein-coupled receptor (GPCR) superfamily, and couples to Gs thus stimulating adenylate cyclase. The subfamily that includes the V2 receptor, the V1a and V1b vasopressin receptors, the oxytocin receptor, and isotocin and mesotocin receptors in non-mammals, is well conserved, though several members signal via other G proteins. All bind similar cyclic nonapeptide hormones. The V2 receptor is expressed in the kidney tubule, predominantly in the distal convoluted tubule and collecting ducts, where its primary property is to respond to the pituitary hormone arginine vasopressin (AVP) by stimulating mechanisms that concentrate the urine and maintain water homeostasis in the organism. When the functi ...more
- ENST00000337474
- ENSP00000338072
- ENSG00000126895
- ENST00000358927
- ENSP00000351805
- ENST00000370049
- ENSP00000359066
- ENST00000646375
- ENSP00000496396
- ADHR
- DIR
- DIR3
- V2R
- DI1
- DIR
- NDI
- V2R
- ADHR
- DIR3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
ligand (chemical) | 1 | ||
biological process | 0.91 | ||
tissue | 0.63 | ||
biological term | 0.6 | ||
cellular component | 0.6 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1107.97 (req: < 5)
Gene RIFs: 87 (req: <= 3)
Antibodies: 262 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1107.97 (req: >= 5)
Gene RIFs: 87 (req: > 3)
Antibodies: 262 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 21
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 420
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 6
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (6)
Active Ligands (420)
Protein-Protein Interactions (322)
Nearest Tclin Targets
Pathways (25)
Reactome (19)
KEGG (3)
PathwayCommons (1)
WikiPathways (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Aquaporin-mediated transport | ||||
Reactome | Cargo recognition for clathrin-mediated endocytosis | ||||
Reactome | Class A/1 (Rhodopsin-like receptors) | ||||
Reactome | Clathrin-mediated endocytosis | ||||
Reactome | Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI) | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Aquaporin-mediated transport | ||||
Cargo recognition for clathrin-mediated endocytosis | ||||
Class A/1 (Rhodopsin-like receptors) | ||||
Clathrin-mediated endocytosis | ||||
Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI) | ||||
Viral Interactions (0)
Gene Ontology Terms (28)
Functions (1)
Components (7)
Processes (20)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations ()
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
1 | 1 | 0 | 1.2 | 53.7 | |||||
albumin:globulin ratio measurement | 1 | 1 | 1 | 36.9 | |||||
1 | 1 | 0 | 1.2 | 17.8 | |||||
1 | 1 | 0 | 1.3 | 15.8 | |||||
mean reticulocyte volume | 1 | 1 | 1 | 7.4 | |||||
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 1.2 | 53.7 | |||||
albumin:globulin ratio measurement | 1 | 36.9 | |||||
0 | 1.2 | 17.8 | |||||
0 | 1.3 | 15.8 | |||||
mean reticulocyte volume | 1 | 7.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | arginine vasopressin receptor 2 | VGNC:1407 | 742565 | |||||
Mouse | MGI:88123 | 12000 | ||||||
Rat | RGD:2186 | 25108 | ||||||
Dog | arginine vasopressin receptor 2 | VGNC:38320 | 403804 | |||||
Horse | arginine vasopressin receptor 2 | VGNC:15712 | 100059066 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | arginine vasopressin receptor 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | arginine vasopressin receptor 2 | |||||
Horse | arginine vasopressin receptor 2 | |||||
Publication Statistics
PubMed Score 1107.97
PubMed score by year
PubTator Score 670.89
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (137)
GeneRif Annotations (87)
Items per page:
0 of 0
PMID | Year | Title |
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