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Tbio
AVIL
Advillin

Protein Summary
Description
Ca(2+)-regulated actin-binding protein. May have a unique function in the morphogenesis of neuronal cells which form ganglia. Required for SREC1-mediated regulation of neurite-like outgrowth. Plays a role in regenerative sensory axon outgrowth and remodeling processes after peripheral injury in neonates. Involved in the formation of long fine actin-containing filopodia-like structures in fibroblast. Plays a role in ciliogenesis. The protein encoded by this gene is a member of the gelsolin/villin family of actin regulatory proteins. This protein has structural similarity to villin. It binds actin and may play a role in the development of neuronal cells that form ganglia. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000257861
  • ENSP00000257861
  • ENSG00000135407

Symbol
  • p92
  • DOC6
  • ADVIL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
gene perturbation
0.93
protein domain
0.73
cell line
0.58
tissue sample
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.58   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 130   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.58   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (67)
RBSN
Tbio
Novelty:  0.0046123
p_int:  0.999900663
p_ni:  0.000099337
Data Source:  BioPlex
DDX11
Tbio
Family:  Enzyme
Novelty:  0.02282234
p_int:  0.999421261
p_ni:  0.000578739
p_wrong:  1e-9
Score:  0.199
Data Source:  BioPlex,STRINGDB
DUS3L
Tdark
Family:  Enzyme
Novelty:  0.24952542
p_int:  0.998378062
p_ni:  0.001605697
p_wrong:  0.000016241
Score:  0.167
Data Source:  BioPlex,STRINGDB
FIGNL1
Tbio
Family:  Enzyme
Novelty:  0.10817841
p_int:  0.995866144
p_ni:  0.003707429
p_wrong:  0.000426427
Data Source:  BioPlex
SCYL1
Tbio
Family:  Kinase
Novelty:  0.03774351
p_int:  0.99531877
p_ni:  0.004681212
p_wrong:  1.8e-8
Score:  0.197
Data Source:  BioPlex,STRINGDB
DOCK7
Tbio
Novelty:  0.03425586
p_int:  0.99117639
p_ni:  0.00882361
Score:  0.168
Data Source:  BioPlex,STRINGDB
VIL1
Tbio
Novelty:  0.00538607
p_int:  0.980875777
p_wrong:  0.019124223
Score:  0.333
Data Source:  BioPlex,STRINGDB
TMOD2
Tbio
Novelty:  0.10324176
p_int:  0.966088172
p_ni:  0.033911828
Score:  0.193
Data Source:  BioPlex,STRINGDB
RICTOR
Tbio
Novelty:  0.00250734
p_int:  0.96419034
p_ni:  0.03580966
Score:  0.166
Data Source:  BioPlex,STRINGDB
RIPK4
Tchem
Family:  Kinase
Novelty:  0.00818379
p_int:  0.959287208
p_ni:  0.028834041
p_wrong:  0.011878751
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
4
0
1.1
94
urate measurement
1
1
1
71.9
high density lipoprotein cholesterol measurement
1
1
1
59.9
mathematical ability
2
2
2
57.7
intelligence
2
2
1
6.8
53.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
94
urate measurement
1
71.9
high density lipoprotein cholesterol measurement
1
59.9
mathematical ability
2
57.7
intelligence
1
6.8
53.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
advillin
VGNC:4942
452029
Macaque
advillin
712581
Mouse
MGI:1333798
11567
Rat
RGD:620301
79253
Dog
advillin
VGNC:38315
474420
Species
Name
OMA
EggNOG
Inparanoid
Chimp
advillin
Macaque
advillin
Mouse
Rat
Dog
advillin
Publication Statistics
PubMed Score 60.58
PubMed score by year
PubTator Score 49.64
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title