Protein Summary
Ca(2+)-regulated actin-binding protein. May have a unique function in the morphogenesis of neuronal cells which form ganglia. Required for SREC1-mediated regulation of neurite-like outgrowth. Plays a role in regenerative sensory axon outgrowth and remodeling processes after peripheral injury in neonates. Involved in the formation of long fine actin-containing filopodia-like structures in fibroblast. Plays a role in ciliogenesis. The protein encoded by this gene is a member of the gelsolin/villin family of actin regulatory proteins. This protein has structural similarity to villin. It binds actin and may play a role in the development of neuronal cells that form ganglia. [provided by RefSeq, Jul 2008]
- ENST00000257861
- ENSP00000257861
- ENSG00000135407
- p92
- DOC6
- ADVIL
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
virus perturbation | 1 | ||
gene perturbation | 0.93 | ||
protein domain | 0.73 | ||
cell line | 0.58 | ||
tissue sample | 0.58 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 60.58 (req: < 5)
Gene RIFs: 3 (req: <= 3)
Antibodies: 130 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 60.58 (req: >= 5)
Gene RIFs: 3 (req: > 3)
Antibodies: 130 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (67)
DDX11
Family: Enzyme
Novelty: 0.02282234
p_int: 0.999421261
p_ni: 0.000578739
p_wrong: 1e-9
Score: 0.199
Data Source: BioPlex,STRINGDB
DUS3L
Family: Enzyme
Novelty: 0.24952542
p_int: 0.998378062
p_ni: 0.001605697
p_wrong: 0.000016241
Score: 0.167
Data Source: BioPlex,STRINGDB
FIGNL1
Family: Enzyme
Novelty: 0.10817841
p_int: 0.995866144
p_ni: 0.003707429
p_wrong: 0.000426427
Data Source: BioPlex
SCYL1
Family: Kinase
Novelty: 0.03774351
p_int: 0.99531877
p_ni: 0.004681212
p_wrong: 1.8e-8
Score: 0.197
Data Source: BioPlex,STRINGDB
DOCK7
Novelty: 0.03425586
p_int: 0.99117639
p_ni: 0.00882361
Score: 0.168
Data Source: BioPlex,STRINGDB
VIL1
Novelty: 0.00538607
p_int: 0.980875777
p_wrong: 0.019124223
Score: 0.333
Data Source: BioPlex,STRINGDB
TMOD2
Novelty: 0.10324176
p_int: 0.966088172
p_ni: 0.033911828
Score: 0.193
Data Source: BioPlex,STRINGDB
RICTOR
Novelty: 0.00250734
p_int: 0.96419034
p_ni: 0.03580966
Score: 0.166
Data Source: BioPlex,STRINGDB
RIPK4
Family: Kinase
Novelty: 0.00818379
p_int: 0.959287208
p_ni: 0.028834041
p_wrong: 0.011878751
Data Source: BioPlex
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (12)
Functions (2)
Components (5)
Processes (5)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (14)
Items per page:
1 – 5 of 14
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
4 | 4 | 0 | 1.1 | 94 | |||||
urate measurement | 1 | 1 | 1 | 71.9 | |||||
high density lipoprotein cholesterol measurement | 1 | 1 | 1 | 59.9 | |||||
mathematical ability | 2 | 2 | 2 | 57.7 | |||||
intelligence | 2 | 2 | 1 | 6.8 | 53.7 | ||||
Items per page:
1 – 5 of 14
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 1.1 | 94 | |||||
urate measurement | 1 | 71.9 | |||||
high density lipoprotein cholesterol measurement | 1 | 59.9 | |||||
mathematical ability | 2 | 57.7 | |||||
intelligence | 1 | 6.8 | 53.7 | ||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | advillin | VGNC:4942 | 452029 | |||||
Macaque | advillin | 712581 | ||||||
Mouse | MGI:1333798 | 11567 | ||||||
Rat | RGD:620301 | 79253 | ||||||
Dog | advillin | VGNC:38315 | 474420 | |||||
Publication Statistics
PubMed Score 60.58
PubMed score by year
PubTator Score 49.64
PubTator score by year
Related Publications
Text Mined References (9)
GeneRif Annotations (3)
Items per page:
0 of 0
PMID | Year | Title |
|---|