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Tbio
AUTS2
Autism susceptibility gene 2 protein

Protein Summary
Description
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:25519132). The PRC1-like complex that contains PCGF5, RNF2, CSNK2B, RYBP and AUTS2 has decreased histone H2A ubiquitination activity, due to the phosphorylation of RNF2 by CSNK2B (PubMed:25519132). As a consequence, the complex mediates transcriptional activation (PubMed:25519132). In the cytoplasm, plays a role in axon and dendrite elongation and in neuronal migration during embryonic brain development. Promotes reorganization of the actin cytoskeleton, lamellipodia formation and neurite elongation via its interaction with RAC guanine nucleotide exchange factors, which then leads to the ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000342771
  • ENSP00000344087
  • ENSG00000158321
  • ENST00000403018
  • ENSP00000385572
  • ENST00000406775
  • ENSP00000385263

Symbol
  • KIAA0442
  • MRD26
  • FBRSL2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.97
small molecule perturbation
0.82
PubMedID
0.81
transcription factor perturbation
0.8
transcription factor
0.78


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.95   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 91   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.95   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 91   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (89)
CSNK2B
Tbio
Family:  Kinase
Novelty:  0.00152367
p_int:  0.999999694
p_ni:  2.84e-7
p_wrong:  2.2e-8
Score:  0.93
Data Source:  BioPlex,STRINGDB
FANCD2OS
Tdark
Novelty:  9.51798561
p_int:  0.999999472
p_ni:  5.27e-7
p_wrong:  1e-9
Data Source:  BioPlex
PCGF5
Tdark
Novelty:  0.11370936
p_int:  0.999999348
p_ni:  6.5e-7
p_wrong:  2e-9
Score:  0.992
Data Source:  BioPlex,STRINGDB
RYBP
Tbio
Novelty:  0.01140945
p_int:  0.999998402
p_ni:  0.000001598
Score:  0.988
Data Source:  BioPlex,STRINGDB
CSNK2A2
Tchem
Family:  Kinase
Novelty:  0.00231447
p_int:  0.999998358
p_ni:  0.000001642
Score:  0.969
Data Source:  BioPlex,STRINGDB
DCAF7
Tbio
Novelty:  0.02609518
p_int:  0.999996179
p_ni:  4.28e-7
p_wrong:  0.000003393
Score:  0.689
Data Source:  BioPlex,STRINGDB
YAF2
Tbio
Novelty:  0.10772286
p_int:  0.999782662
p_ni:  0.000133271
p_wrong:  0.000084068
Score:  0.991
Data Source:  BioPlex,STRINGDB
PCGF6
Tbio
Novelty:  0.07032909
p_int:  0.997520943
p_ni:  0.000374241
p_wrong:  0.002104816
Score:  0.774
Data Source:  BioPlex,STRINGDB
RNF2
Tbio
Family:  Enzyme
Novelty:  0.00859204
Score:  0.952
Data Source:  STRINGDB
RING1
Tbio
Family:  Enzyme
Novelty:  0.00729948
Score:  0.941
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Reactome
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Reactome
Transcriptional regulation by RUNX1
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Transcriptional regulation by RUNX1
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (16)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Disease Associations (null)
No disease associations found
GWAS Traits (50)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
type 2 diabetes mellitus
6
6
4
1.1
96.6
body mass index
6
6
7
90.2
risk-taking behaviour
2
3
3
88.4
smoking status measurement
2
2
3
85.5
self reported educational attainment
2
7
7
83.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
type 2 diabetes mellitus
4
1.1
96.6
body mass index
7
90.2
risk-taking behaviour
3
88.4
smoking status measurement
3
85.5
self reported educational attainment
7
83.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
AUTS2, activator of transcription and developmental regulator
VGNC:4277
463457
Macaque
AUTS2, activator of transcription and developmental regulator
701038
Mouse
MGI:1919847
319974
Rat
RGD:2323959
100362819
Dog
AUTS2, activator of transcription and developmental regulator
VGNC:38314
479709
Species
Name
OMA
EggNOG
Inparanoid
Chimp
AUTS2, activator of transcription and developmental regulator
Macaque
AUTS2, activator of transcription and developmental regulator
Mouse
Rat
Dog
AUTS2, activator of transcription and developmental regulator
Publication Statistics
PubMed Score 80.95
PubMed score by year
PubTator Score 36.66
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title