Protein Summary
Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Plays also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. AURKC phosphorylates the CPC complex subunits BIRC5/survivin and INCENP leading to increased AURKC activity. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'. This gene encodes a member of the Aurora subfamily of serine/threonine protein kinases. The encoded protein is a chromosomal passenger protein that forms complexes with Aurora-B and inner centromere proteins and may play a role in organizing microtubules ...more
- ENST00000302804
- ENSP00000302898
- ENSG00000105146
- ENST00000415300
- ENSP00000407162
- ENST00000598785
- ENSP00000471830
- AIE2
- AIK3
- AIRK3
- ARK3
- STK13
- AIE2
- AIK3
- ARK3
- AurC
- SPGF5
- STK13
- HEL-S-90
- aurora-C
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
molecular function | 0.94 | ||
cellular component | 0.81 | ||
small molecule | 0.75 | ||
protein domain | 0.73 | ||
tissue | 0.63 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 102.49 (req: < 5)
Gene RIFs: 40 (req: <= 3)
Antibodies: 468 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 102.49 (req: >= 5)
Gene RIFs: 40 (req: > 3)
Antibodies: 468 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 15
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 32
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (1)
Active Ligands (32)
Protein-Protein Interactions (143)
MYH8
Novelty: 0.01020559
p_int: 0.999992659
p_ni: 0.000007341
Score: 0.313
Data Source: BioPlex,STRINGDB
INCENP
Novelty: 0.00704937
p_int: 0.999989338
p_ni: 0.000008903
p_wrong: 0.000001759
Score: 0.998
Data Source: BioPlex,STRINGDB
MYH1
Novelty: 0.00472973
p_int: 0.999974673
p_ni: 0.000025321
p_wrong: 6e-9
Score: 0.313
Data Source: BioPlex,STRINGDB
MYH4
Novelty: 0.00556982
p_int: 0.999937882
p_ni: 0.000062118
Score: 0.3
Data Source: BioPlex,STRINGDB
CUSTOS
Novelty: 0.50471779
p_int: 0.998557528
p_ni: 0.001442347
p_wrong: 1.25e-7
Score: 0.188
Data Source: BioPlex,STRINGDB
USP19
Family: Enzyme
Novelty: 0.04078253
p_int: 0.998263125
p_ni: 0.001736875
Score: 0.257
Data Source: BioPlex,STRINGDB
DHX38
Family: Enzyme
Novelty: 0.01939445
p_int: 0.970154185
p_ni: 0.029737391
p_wrong: 0.000108424
Score: 0.163
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (3)
PathwayCommons (3)
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
PathwayCommons: pid | Signaling by Aurora kinases | ||||
PathwayCommons: pid | Aurora B signaling | ||||
PathwayCommons: pid | Aurora C signaling | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Signaling by Aurora kinases | ||||
Aurora B signaling | ||||
Aurora C signaling | ||||
Viral Interactions (0)
Gene Ontology Terms (24)
Functions (4)
Components (9)
Processes (11)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
Dupuytren Contracture | 2 | 1 | 0 | 1.3 | 68.6 | ||||
tumor necrosis factor, receptor superfamily, member 5 measurement | 1 | 1 | 1 | 59 | |||||
heel bone mineral density | 2 | 1 | 2 | 57.8 | |||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
Dupuytren Contracture | 0 | 1.3 | 68.6 | ||||
tumor necrosis factor, receptor superfamily, member 5 measurement | 1 | 59 | |||||
heel bone mineral density | 2 | 57.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | aurora kinase C | VGNC:2099 | 740217 | |||||
Macaque | aurora kinase C | 709801 | ||||||
Mouse | MGI:1321119 | 20871 | ||||||
Dog | aurora kinase C | VGNC:38313 | 102155400 | |||||
Horse | aurora kinase C | VGNC:15705 | 100051177 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | aurora kinase C | |||||
Macaque | aurora kinase C | |||||
Mouse | ||||||
Dog | aurora kinase C | |||||
Horse | aurora kinase C | |||||
Publication Statistics
PubMed Score 102.49
PubMed score by year
PubTator Score 70.13
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (50)
GeneRif Annotations (40)
Items per page:
0 of 0
PMID | Year | Title |
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