Tchem AURKC Aurora kinase C

Protein Summary

Description

Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Plays also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. AURKC phosphorylates the CPC complex subunits BIRC5/survivin and INCENP leading to increased AURKC activity. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'. This gene encodes a member of the Aurora subfamily of serine/threonine protein kinases. The encoded protein is a chromosomal passenger protein that forms complexes with Aurora-B and inner centromere proteins and may play a role in organizing microtubules in relation to centrosome/spindle function during mitosis. This gene is overexpressed in several cancer cell lines, suggesting an involvement in oncogenic signal transduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9UQB9
• O60681
• O75442
• Q6AZY8
• Q6DLZ0
• Q9UPK5

Gene Name

• AURKC

Ensembl ID

• ENST00000302804
• ENSP00000302898
• ENSG00000105146
• ENST00000415300
• ENSP00000407162
• ENST00000598785
• ENSP00000471830

Symbol

• AIE2
• AIK3
• AIRK3
• ARK3
• STK13
• AIE2
• AIK3
• ARK3
• AurC
• SPGF5
• STK13
• HEL-S-90
• aurora-C

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.94
cellular component	0.81
small molecule	0.75
protein domain	0.73
tissue	0.63

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Protein Kinase / Non-receptor Serine/threonine Protein Kinase / Aurora Kinase C

DTO Classes

Protein / Kinase / Protein Kinase / Other Group / Aur Family / Aurora Kinase C

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 102.49   (req: < 5)

Gene RIFs: 40   (req: <= 3)

Antibodies: 468   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 102.49   (req: >= 5)

Gene RIFs: 40   (req: > 3)

Antibodies: 468   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 32

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

ProKinO

The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.

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Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (1)

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1 – 1 of 1

axitinib

AURKCTchem Kinase

INHIBITOR pKd : 6.77

Active Ligands (32)

Explore Active Ligands

1 – 10 of 32

staurosporine

AURKCTchem Kinase

pKd : 7.89

lestaurtinib

AURKCTchem Kinase

pKd : 7.57

foretinib

AURKCTchem Kinase

pKd : 7.92

ilorasertib

AURKCTchem Kinase

pKi : 7.9

tozasertib

AURKCTchem Kinase

pKd : 7.55

danusertib

AURKCTchem Kinase

pKd : 7.75

SU6656

AURKCTchem Kinase

pIC50 : 7.77

MK-5108

AURKCTchem Kinase

pKd : 10

MLN-8054

AURKCTchem Kinase

pKd : 8.19

barasertib

AURKCTchem Kinase

pKd : 7.48

Protein-Protein Interactions (143)

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1 – 10 of 143

• See Interactions on String-DB

MYH8

Tbio

Novelty:  0.01020559

p_int:  0.999992659

p_ni:  0.000007341

Score:  0.313

Data Source:  BioPlex,STRINGDB

INCENP

Tbio

Novelty:  0.00704937

p_int:  0.999989338

p_ni:  0.000008903

p_wrong:  0.000001759

Score:  0.998

Data Source:  BioPlex,STRINGDB

MYH1

Tbio

Novelty:  0.00472973

p_int:  0.999974673

p_ni:  0.000025321

p_wrong:  6e-9

Score:  0.313

Data Source:  BioPlex,STRINGDB

HSP90AA4P

Tdark

p_int:  0.99996637

p_ni:  0.000033208

p_wrong:  4.22e-7

Data Source:  BioPlex

HSP90AB3P

Tdark

p_int:  0.999947865

p_ni:  0.000052135

Data Source:  BioPlex

MYH4

Tbio

Novelty:  0.00556982

p_int:  0.999937882

p_ni:  0.000062118

Score:  0.3

Data Source:  BioPlex,STRINGDB

HSP90AA5P

Tdark

p_int:  0.998914745

p_ni:  0.001085255

Data Source:  BioPlex

CUSTOS

Tdark

Novelty:  0.50471779

p_int:  0.998557528

p_ni:  0.001442347

p_wrong:  1.25e-7

Score:  0.188

Data Source:  BioPlex,STRINGDB

USP19

Tbio

Family:  Enzyme

Novelty:  0.04078253

p_int:  0.998263125

p_ni:  0.001736875

Score:  0.257

Data Source:  BioPlex,STRINGDB

DHX38

Tbio

Family:  Enzyme

Novelty:  0.01939445

p_int:  0.970154185

p_ni:  0.029737391

p_wrong:  0.000108424

Score:  0.163

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (3)

PathwayCommons (3)

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5

1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
PathwayCommons: pid	Signaling by Aurora kinases	3 targets	PathwayCommons: pid
PathwayCommons: pid	Aurora B signaling	40 targets	PathwayCommons: pid
PathwayCommons: pid	Aurora C signaling	4 targets	PathwayCommons: pid

Name	Explore in Pharos	Explore in Source
Signaling by Aurora kinases	3 targets	PathwayCommons: pid
Aurora B signaling	40 targets	PathwayCommons: pid
Aurora C signaling	4 targets	PathwayCommons: pid

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (24)

Functions (4)

Components (9)

Processes (11)

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10

1 – 4 of 4

GO Term	Evidence	Assigned by
protein kinase activity	Inferred from Direct Assay (IDA)	UniProtKB
histone serine kinase activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
protein serine/threonine/tyrosine kinase activity	Traceable Author Statement (TAS)	UniProtKB
ATP binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations ()

No disease associations found

GWAS Traits (3)

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5

1 – 3 of 3

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
Dupuytren Contracture	EFO_0004229	2	1	0	1.3	68.6
tumor necrosis factor, receptor superfamily, member 5 measurement	EFO_0010607	1	1	1		59
heel bone mineral density	EFO_0009270	2	1	2		57.8

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 3 of 3

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
Dupuytren Contracture	EFO_0004229	0	1.3	68.6
tumor necrosis factor, receptor superfamily, member 5 measurement	EFO_0010607	1		59
heel bone mineral density	EFO_0009270	2		57.8

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
ATP-binding
Cell cycle
Cell division
Centromere
Chromosome
Complete proteome
Cytoplasm
Cytoskeleton
Kinase

GWAS Trait Find Similar Targets

No Header	No Header
Dupuytren Contracture
heel bone mineral density
tumor necrosis factor, receptor superfamily, member 5 measurement

MGI Phenotype Find Similar Targets

No Header	No Header
cellular phenotype
reproductive system phenotype

IDG Resources

No IDG generated resources found

Orthologs (8)

1 – 5 of 8

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	aurora kinase C	VGNC:2099	740217
Macaque	aurora kinase C		709801
Mouse	aurora kinase C	MGI:1321119	20871
Dog	aurora kinase C	VGNC:38313	102155400
Horse	aurora kinase C	VGNC:15705	100051177

Species	Name	OMA	EggNOG	Inparanoid
Chimp	aurora kinase C
Macaque	aurora kinase C
Mouse	aurora kinase C
Dog	aurora kinase C
Horse	aurora kinase C

Publication Statistics

PubMed Score 102.49

PubMed score by year

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PubTator Score 70.13

PubTator score by year

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Patents

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Related Publications

Text Mined References (50)

GeneRif Annotations (40)

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PMID	Year	Title