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Tchem
AURKC
Aurora kinase C

Protein Summary
Description
Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Plays also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. AURKC phosphorylates the CPC complex subunits BIRC5/survivin and INCENP leading to increased AURKC activity. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'. This gene encodes a member of the Aurora subfamily of serine/threonine protein kinases. The encoded protein is a chromosomal passenger protein that forms complexes with Aurora-B and inner centromere proteins and may play a role in organizing microtubules ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302804
  • ENSP00000302898
  • ENSG00000105146
  • ENST00000415300
  • ENSP00000407162
  • ENST00000598785
  • ENSP00000471830

Symbol
  • AIE2
  • AIK3
  • AIRK3
  • ARK3
  • STK13
  • AIE2
  • AIK3
  • ARK3
  • AurC
  • SPGF5
  • STK13
  • HEL-S-90
  • aurora-C
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.94
cellular component
0.81
small molecule
0.75
protein domain
0.73
tissue
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 114.81   (req: < 5)
Gene RIFs: 40   (req: <= 3)
Antibodies: 468   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 114.81   (req: >= 5)
Gene RIFs: 40   (req: > 3)
Antibodies: 468   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 32
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1