Tchem AURKC Aurora kinase C

Protein Summary

Description

Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Plays also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. AURKC phosphorylates the CPC complex subunits BIRC5/survivin and INCENP leading to increased AURKC activity. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'. This gene encodes a member of the Aurora subfamily of serine/threonine protein kinases. The encoded protein is a chromosomal passenger protein that forms complexes with Aurora-B and inner centromere proteins and may play a role in organizing microtubules in relation to centrosome/spindle function during mitosis. This gene is overexpressed in several cancer cell lines, suggesting an involvement in oncogenic signal transduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9UQB9
• O60681
• O75442
• Q6AZY8
• Q6DLZ0
• Q9UPK5

Gene Name

• AURKC

Ensembl ID

• ENST00000302804
• ENSP00000302898
• ENSG00000105146
• ENST00000415300
• ENSP00000407162
• ENST00000598785
• ENSP00000471830

Symbol

• AIE2
• AIK3
• AIRK3
• ARK3
• STK13
• AIE2
• AIK3
• ARK3
• AurC
• SPGF5
• STK13
• HEL-S-90
• aurora-C

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.94
cellular component	0.81
small molecule	0.75
protein domain	0.73
tissue	0.63

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Protein Kinase / Non-receptor Serine/threonine Protein Kinase / Aurora Kinase C

DTO Classes

Protein / Kinase / Protein Kinase / Other Group / Aur Family / Aurora Kinase C

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 114.81   (req: < 5)

Gene RIFs: 53   (req: <= 3)

Antibodies: 468   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 114.81   (req: >= 5)

Gene RIFs: 53   (req: > 3)

Antibodies: 468   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 32

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1