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Tchem
AURKB
Aurora kinase B

Protein Summary
Description
Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis. Required for central/midzone spindle assembly and cleavage furrow formation. Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: phosphorylates CHMP4C, leading to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis (PubMed:22422861, PubMed:24814515). AURKB phosphorylates the CPC complex ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000316199
  • ENSP00000313950
  • ENSG00000178999
  • ENST00000534871
  • ENSP00000443869
  • ENST00000578549
  • ENSP00000462207
  • ENST00000585124
  • ENSP00000463999

Symbol
  • AIK2
  • AIM1
  • AIRK2
  • ARK2
  • STK1
  • STK12
  • STK5
  • AIK2
  • AIM1
  • ARK2
  • AurB
  • IPL1
  • STK5
  • AIM-1
  • ARK-2
  • STK-1
  • STK12
  • PPP1R48
  • aurkb-sv1
  • aurkb-sv2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
gene perturbation
0.99
biological process
0.98
molecular function
0.96
chemical bioactivity profile
0.94


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1128.72   (req: < 5)
Gene RIFs: 280   (req: <= 3)
Antibodies: 993   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1128.72   (req: >= 5)
Gene RIFs: 280   (req: > 3)
Antibodies: 993   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 34
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 766
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1