Tchem AURKB Aurora kinase B

Protein Summary

Description

Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis. Required for central/midzone spindle assembly and cleavage furrow formation. Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: phosphorylates CHMP4C, leading to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis (PubMed:22422861, PubMed:24814515). AURKB phosphorylates the CPC complex subunits BIRC5/survivin, CDCA8/borealin and INCENP. Phosphorylation of INCENP leads to increased AURKB activity. Other known AURKB substrates involved in centromeric functions and mitosis are CENPA, DES/desmin, GPAF, KIF2C, NSUN2, RACGAP1, SEPT1, VIM/vimentin, HASPIN, and histone H3. A positive feedback loop involving HASPIN and AURKB contributes to localization of CPC to centromeres. Phosphorylation of VIM controls vimentin filament segregation in cytokinetic process, whereas histone H3 is phosphorylated at 'Ser-10' and 'Ser-28' during mitosis (H3S10ph and H3S28ph, respectively). A positive feedback between HASPIN and AURKB contributes to CPC localization. AURKB is also required for kinetochore localization of BUB1 and SGO1. Phosphorylation of p53/TP53 negatively regulates its transcriptional activity. Key regulator of active promoters in resting B- and T-lymphocytes: acts by mediating phosphorylation of H3S28ph at active promoters in resting B-cells, inhibiting RNF2/RING1B-mediated ubiquitination of histone H2A and enhancing binding and activity of the USP16 deubiquitinase at transcribed genes. This gene encodes a member of the aurora kinase subfamily of serine/threonine kinases. The genes encoding the other two members of this subfamily are located on chromosomes 19 and 20. These kinases participate in the regulation of alignment and segregation of chromosomes during mitosis and meiosis through association with microtubules. A pseudogene of this gene is located on chromosome 8. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2015]

Uniprot Accession IDs

• Q96GD4
• B4DNM4
• C7G533
• C7G534
• C7G535
• D3DTR4
• J9JID1
• O14630
• O60446
• O95083
• Q96DV5
• Q9UQ46

Gene Name

• AURKB

Ensembl ID

• ENST00000316199
• ENSP00000313950
• ENSG00000178999
• ENST00000534871
• ENSP00000443869
• ENST00000578549
• ENSP00000462207
• ENST00000585124
• ENSP00000463999

Symbol

• AIK2
• AIM1
• AIRK2
• ARK2
• STK1
• STK12
• STK5
• AIK2
• AIM1
• ARK2
• AurB
• IPL1
• STK5
• AIM-1
• ARK-2
• STK-1
• STK12
• PPP1R48
• aurkb-sv1
• aurkb-sv2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	1
gene perturbation	0.99
biological process	0.98
molecular function	0.96
chemical bioactivity profile	0.94

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Protein Kinase / Non-receptor Serine/threonine Protein Kinase / Aurora Kinase B

DTO Classes

Protein / Kinase / Protein Kinase / Other Group / Aur Family / Aurora Kinase B

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1128.72   (req: < 5)

Gene RIFs: 357   (req: <= 3)

Antibodies: 993   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1128.72   (req: >= 5)

Gene RIFs: 357   (req: > 3)

Antibodies: 993   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 34

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 766

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1