Tchem AURKAIP1 Aurora kinase A-interacting protein

Protein Summary

Description

May act as a negative regulator of Aurora-A kinase, by down-regulation through proteasome-dependent degradation.

Uniprot Accession IDs

• Q9NWT8
• Q5TA36
• Q8TBD3
• AURKA-interacting protein

Gene Name

• AURKAIP1

Ensembl ID

• ENST00000321751
• ENSP00000319778
• ENSG00000175756
• ENST00000338338
• ENSP00000340656
• ENST00000338370
• ENSP00000342676
• ENST00000378853
• ENSP00000368130

Symbol

• AIP
• AKIP
• MRPS38
• AIP
• AKIP
• MRP-S38

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.96
kinase perturbation	0.88
transcription factor binding site profile	0.77
histone modification site profile	0.76
transcription factor	0.69

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.23   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 68   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.23   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 68   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0