Tchem AURKAIP1 Aurora kinase A-interacting protein

Protein Summary

Description

May act as a negative regulator of Aurora-A kinase, by down-regulation through proteasome-dependent degradation.

Uniprot Accession IDs

• Q9NWT8
• Q5TA36
• Q8TBD3
• AURKA-interacting protein

Gene Name

• AURKAIP1

Ensembl ID

• ENST00000321751
• ENSP00000319778
• ENSG00000175756
• ENST00000338338
• ENSP00000340656
• ENST00000338370
• ENSP00000342676
• ENST00000378853
• ENSP00000368130

Symbol

• AIP
• AKIP
• MRPS38
• AIP
• AKIP
• MRP-S38

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.96
kinase perturbation	0.88
transcription factor binding site profile	0.77
histone modification site profile	0.76
transcription factor	0.69

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.9   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 68   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.9   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 68   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (1)

Explore Active Ligands

1 – 1 of 1

tozasertib

AURKAIP1Tchem Enzyme

pKd : 7.55

Protein-Protein Interactions (157)

Explore Interacting Targets

1 – 10 of 157

• See Interactions on String-DB

MMADHC

Tbio

Novelty:  0.02299238

p_int:  0.999989564

p_ni:  0.000010436

Data Source:  BioPlex

NRDC

Tbio

Family:  Enzyme

Novelty:  0.01825187

p_int:  0.999955658

p_ni:  0.000044342

Data Source:  BioPlex

NOA1

Tbio

Novelty:  0.01478325

p_int:  0.999059175

p_ni:  0.000940824

p_wrong:  1e-9

Score:  0.77

Data Source:  BioPlex,STRINGDB

WDR83

Tbio

Novelty:  0.11602568

p_int:  0.998764741

p_ni:  0.001234797

p_wrong:  4.62e-7

Score:  0.199

Data Source:  BioPlex,STRINGDB

STRBP

Tbio

Novelty:  0.00919158

p_int:  0.99762392

p_ni:  0.00237608

Score:  0.248

Data Source:  BioPlex,STRINGDB

NSUN4

Tbio

Family:  Enzyme

Novelty:  0.15593771

p_int:  0.997042713

p_ni:  0.002886208

p_wrong:  0.000071078

Score:  0.499

Data Source:  BioPlex,STRINGDB

MRPS18C

Tdark

Novelty:  0.42868428

p_int:  0.993110106

p_ni:  0.006889883

p_wrong:  1.1e-8

Score:  0.992

Data Source:  BioPlex,STRINGDB

DCAF1

Tbio

Novelty:  0.0170232

p_int:  0.99212492

p_ni:  0.00787508

Data Source:  BioPlex

UBE2O

Tbio

Novelty:  0.07084123

p_int:  0.989284756

p_ni:  0.010715243

p_wrong:  1e-9

Data Source:  BioPlex

MRPS11

Tdark

Novelty:  0.29449255

p_int:  0.987329342

p_ni:  0.012670658

Score:  0.997

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (7)

Reactome (6)

PathwayCommons (1)

Metabolism of proteins (R-HSA-392499)

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5

1 – 5 of 6

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Metabolism of proteins	2050 targets	R-HSA-392499
Reactome	Mitochondrial translation	96 targets	R-HSA-5368287
Reactome	Mitochondrial translation elongation	90 targets	R-HSA-5389840
Reactome	Mitochondrial translation initiation	90 targets	R-HSA-5368286
Reactome	Mitochondrial translation termination	90 targets	R-HSA-5419276

Name	Explore in Pharos	Explore in Source
Metabolism of proteins	2050 targets	R-HSA-392499
Mitochondrial translation	96 targets	R-HSA-5368287
Mitochondrial translation elongation	90 targets	R-HSA-5389840
Mitochondrial translation initiation	90 targets	R-HSA-5368286
Mitochondrial translation termination	90 targets	R-HSA-5419276

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (11)

Components (6)

Processes (5)

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10

1 – 6 of 6

GO Term	Evidence	Assigned by
intracellular membrane-bounded organelle	Inferred from Direct Assay (IDA)	HPA
mitochondrion	Inferred from Direct Assay (IDA)	HPA
nucleoplasm	Inferred from Direct Assay (IDA)	HPA
nucleus	Inferred from Direct Assay (IDA)	UniProtKB
mitochondrial inner membrane	Traceable Author Statement (TAS)	Reactome
ribosome	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations (null)

No disease associations found

GWAS Traits (4)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 4 of 4

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
inflammatory bowel disease	EFO_0003767	2	1	0	1.1	56.2
intraocular pressure measurement	EFO_0004695	1	2	2		52.7
ulcerative colitis	EFO_0000729	1	1	0	1.1	35
heel bone mineral density	EFO_0009270	1	1	1		6.7

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 4 of 4

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
inflammatory bowel disease	EFO_0003767	0	1.1	56.2
intraocular pressure measurement	EFO_0004695	2		52.7
ulcerative colitis	EFO_0000729	0	1.1	35
heel bone mineral density	EFO_0009270	1		6.7

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Complete proteome
Mitochondrion
Nucleus
Polymorphism
Reference proteome
Ribonucleoprotein
Ribosomal protein

GWAS Trait Find Similar Targets

No Header	No Header
heel bone mineral density
inflammatory bowel disease
intraocular pressure measurement
ulcerative colitis

IDG Resources

No IDG generated resources found

Orthologs (8)

1 – 5 of 8

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	aurora kinase A interacting protein 1	VGNC:451	100611076
Mouse	aurora kinase A interacting protein 1	MGI:1913327	66077
Dog	aurora kinase A interacting protein 1		607067
Cow	aurora kinase A interacting protein 1	VGNC:26350	506359
Opossum	aurora kinase A interacting protein 1 [Source:HGNC Symbol;Acc:HGNC:24114]

Species	Name	OMA	EggNOG	Inparanoid
Chimp	aurora kinase A interacting protein 1
Mouse	aurora kinase A interacting protein 1
Dog	aurora kinase A interacting protein 1
Cow	aurora kinase A interacting protein 1
Opossum	aurora kinase A interacting protein 1 [Source:HGNC Symbol;Acc:HGNC:24114]

Publication Statistics

PubMed Score 4.90

PubMed score by year

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PubTator Score 1.53

PubTator score by year

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Related Publications

Text Mined References (23)

GeneRif Annotations (10)

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10

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PMID	Year	Title