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Tchem
AURKA
Aurora kinase A

Protein Summary
Description
Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2. Regulates KIF2A tubulin depolymerase activity. Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization. Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cell ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000312783
  • ENSP00000321591
  • ENSG00000087586
  • ENST00000347343
  • ENSP00000216911
  • ENST00000371356
  • ENSP00000360407
  • ENST00000395911
  • ENSP00000379247
  • ENST00000395913
  • ENSP00000379249
  • ENST00000395914
  • ENSP00000379250
  • ENST00000395915
  • ENSP00000379251

Symbol
  • AIK
  • AIRK1
  • ARK1
  • AURA
  • AYK1
  • BTAK
  • IAK1
  • STK15
  • STK6
  • AIK
  • ARK1
  • AURA
  • BTAK
  • STK6
  • STK7
  • STK15
  • PPP1R47
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.99
interacting protein
0.99
biological term
0.98
molecular function
0.98
transcription factor perturbation
0.96


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1114.4   (req: < 5)
Gene RIFs: 527   (req: <= 3)
Antibodies: 972   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1114.4   (req: >= 5)
Gene RIFs: 527   (req: > 3)
Antibodies: 972   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 36
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1097
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (630)
ITPKC
Tchem
Family:  Kinase
Novelty:  0.03063007
p_int:  0.999999857
p_ni:  1.41e-7
p_wrong:  2e-9
Score:  0.415
Data Source:  BioPlex,STRINGDB
CEP192
Tbio
Novelty:  0.05738998
p_int:  0.999999753
p_ni:  1.64e-7
p_wrong:  8.3e-8
Score:  0.994
Data Source:  BioPlex,STRINGDB
SNX18
Tbio
Novelty:  0.10461787
p_int:  0.99999928
p_ni:  7.2e-7
Data Source:  BioPlex
TPX2
Tbio
Novelty:  0.00435921
p_int:  0.999994627
p_ni:  0.000005373
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
PLA2G10
Tchem
Family:  Enzyme
Novelty:  0.00289317
p_int:  0.999991925
p_ni:  0.000008075
Data Source:  BioPlex
ENTR1
Tbio
Novelty:  0.32267064
p_int:  0.999990997
p_ni:  0.000008988
p_wrong:  1.5e-8
Score:  0.229
Data Source:  BioPlex,STRINGDB
MTMR4
Tbio
Family:  Enzyme
Novelty:  0.09166984
p_int:  0.999986106
p_ni:  0.000013891
p_wrong:  3e-9
Score:  0.205
Data Source:  BioPlex,STRINGDB
SETD2
Tchem
Family:  Epigenetic
Novelty:  0.00178899
p_int:  0.999974585
p_ni:  0.000025415
Score:  0.42
Data Source:  BioPlex,STRINGDB
OSBPL3
Tbio
Novelty:  0.06106368
p_int:  0.999940439
p_ni:  0.000059561
Data Source:  BioPlex
SCYL1
Tbio
Family:  Kinase
Novelty:  0.03774351
p_int:  0.999927883
p_ni:  0.000072117
Score:  0.181
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (34)
APC/C-mediated degradation of cell cycle proteins (R-HSA-174143)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 24
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
APC/C-mediated degradation of cell cycle proteins
Reactome
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Reactome
AURKA Activation by TPX2
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Name
Explore in Pharos
Explore in Source
APC/C-mediated degradation of cell cycle proteins
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
AURKA Activation by TPX2
Cell Cycle
Cell Cycle, Mitotic
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (56)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Alzheimer disease
2
2
0
5.5
72.7
platelet crit
2
2
2
70.4
family history of Alzheimer’s disease
1
2
0
5.9
64.3
platelet count
3
2
3
64
mean corpuscular hemoglobin concentration
1
1
1
29.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Alzheimer disease
0
5.5
72.7
platelet crit
2
70.4
family history of Alzheimer’s disease
0
5.9
64.3
platelet count
3
64
mean corpuscular hemoglobin concentration
1
29.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
aurora kinase A
VGNC:6047
469980
Macaque
aurora kinase A
698190
Mouse
MGI:894678
20878
Rat
RGD:628895
261730
Dog
aurora kinase A
VGNC:38311
485940
Species
Name
OMA
EggNOG
Inparanoid
Chimp
aurora kinase A
Macaque
aurora kinase A
Mouse
Rat
Dog
aurora kinase A
Publication Statistics
PubMed Score 1114.40
PubMed score by year
PubTator Score 1026.11
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title