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Tbio
ATXN7L3
Ataxin-7-like protein 3

Protein Summary
Description
Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B (PubMed:18206972, PubMed:21746879). The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Within the complex, it is required to recruit USP22 and ENY2 into the SAGA complex (PubMed:18206972). Regulates H2B monoubiquitination (H2Bub1) levels. Affects subcellular distribution of ENY2, USP22 and ATXN7L3B (PubMed:27601583).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000389384
  • ENSP00000374035
  • ENSG00000087152
  • ENST00000454077
  • ENSP00000397259
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.83
microRNA
0.68
biological process
0.63
tissue sample
0.62
kinase perturbation
0.6


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.88   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 65   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.88   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 65   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (66)
ATXN7
Tbio
Novelty:  0.00323014
p_int:  0.999999999
p_ni:  1e-9
Score:  0.996
Data Source:  BioPlex,STRINGDB
USP27X
Tbio
Family:  Enzyme
Novelty:  0.12550111
p_int:  0.999999875
p_ni:  6.3e-8
p_wrong:  6.2e-8
Score:  0.918
Data Source:  BioPlex,STRINGDB
ATXN7L2
Tdark
Novelty:  2.89202293
p_int:  0.999999842
p_ni:  7e-9
p_wrong:  1.5e-7
Score:  0.696
Data Source:  BioPlex,STRINGDB
USP22
Tbio
Family:  Enzyme
Novelty:  0.01416662
p_int:  0.999999543
p_ni:  3.66e-7
p_wrong:  9.1e-8
Score:  0.991
Data Source:  BioPlex,STRINGDB
ATXN7L1
Tdark
Novelty:  0.43694835
p_int:  0.999999538
p_ni:  1.1e-8
p_wrong:  4.53e-7
Score:  0.934
Data Source:  BioPlex,STRINGDB
TADA1
Tdark
Novelty:  0.09903801
p_int:  0.999981011
p_ni:  0.000018989
Score:  0.996
Data Source:  BioPlex,STRINGDB
TADA2B
Tbio
Family:  TF
Novelty:  0.06387677
p_int:  0.999976449
p_ni:  0.000022891
p_wrong:  6.61e-7
Score:  0.998
Data Source:  BioPlex,STRINGDB
TAF5L
Tbio
Family:  Enzyme
Novelty:  0.29525944
p_int:  0.999971321
p_ni:  0.000028679
Score:  0.992
Data Source:  BioPlex,STRINGDB
TAF9B
Tbio
Novelty:  0.0285313
p_int:  0.999952836
p_ni:  0.000047164
Score:  0.991
Data Source:  BioPlex,STRINGDB
SUPT7L
Tdark
Novelty:  0.20661559
p_int:  0.999869264
p_ni:  0.000123585
p_wrong:  0.000007151
Score:  0.991
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
HATs acetylate histones
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
HATs acetylate histones
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (28)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
6
6
9
98.8
mean corpuscular volume
2
4
4
98.1
reticulocyte measurement
3
4
6
97.8
mean reticulocyte volume
1
4
4
96.5
red blood cell distribution width
4
2
4
92.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
9
98.8
mean corpuscular volume
4
98.1
reticulocyte measurement
6
97.8
mean reticulocyte volume
4
96.5
red blood cell distribution width
4
92.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
ataxin 7 like 3
714437
Mouse
MGI:3036270
217218
Rat
RGD:1311493
287734
Dog
ataxin 7 like 3
VGNC:38306
612754
Horse
ataxin 7 like 3
VGNC:15699
100064752
Species
Name
OMA
EggNOG
Inparanoid
Macaque
ataxin 7 like 3
Mouse
Rat
Dog
ataxin 7 like 3
Horse
ataxin 7 like 3
Publication Statistics
PubMed Score 6.88
PubMed score by year
PubTator Score 1.22
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title