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Tdark
ATXN7L1
Ataxin-7-like protein 1

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000318724
  • ENSP00000326344
  • ENSG00000146776
  • ENST00000419735
  • ENSP00000410759
  • ENST00000477775
  • ENSP00000418476

Symbol
  • ATXN7L4
  • KIAA1218
  • ATXN7L4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.91
transcription factor binding site profile
0.9
transcription factor
0.87
histone modification site profile
0.81
disease perturbation
0.79


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.7   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 194   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.7   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 194   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (108)
USP27X
Tbio
Family:  Enzyme
Novelty:  0.12550111
p_int:  0.999999973
p_ni:  2.5e-8
p_wrong:  2e-9
Score:  0.561
Data Source:  BioPlex,STRINGDB
USP22
Tbio
Family:  Enzyme
Novelty:  0.01416662
p_int:  0.999999566
p_ni:  4.34e-7
Score:  0.627
Data Source:  BioPlex,STRINGDB
ATXN7L3
Tbio
Novelty:  0.1572083
p_int:  0.999999538
p_ni:  1.1e-8
p_wrong:  4.53e-7
Score:  0.934
Data Source:  BioPlex,STRINGDB
TAF12
Tbio
Novelty:  0.04352637
p_int:  0.999997754
p_ni:  0.000001801
p_wrong:  4.44e-7
Score:  0.829
Data Source:  BioPlex,STRINGDB
MAU2
Tdark
Novelty:  0.00594861
p_int:  0.999864229
p_ni:  0.00009853
p_wrong:  0.000037241
Data Source:  BioPlex
HSD17B8
Tbio
Family:  Enzyme
Novelty:  0.00915958
p_int:  0.999822742
p_ni:  0.000045395
p_wrong:  0.000131862
Data Source:  BioPlex
PHF23
Tbio
Family:  Epigenetic
Novelty:  0.17699844
p_int:  0.999682861
p_ni:  0.000006652
p_wrong:  0.000310488
Data Source:  BioPlex
KCTD9
Tbio
Novelty:  0.22841768
p_int:  0.998771011
p_ni:  0.001228784
p_wrong:  2.04e-7
Data Source:  BioPlex
APAF1
Tchem
Family:  Enzyme
Novelty:  0.00107622
p_int:  0.998753178
p_ni:  0.001245572
p_wrong:  0.00000125
Score:  0.366
Data Source:  BioPlex,STRINGDB
MEIS2
Tbio
Family:  TF
Novelty:  0.01393828
p_int:  0.998605013
p_ni:  0.001329957
p_wrong:  0.000065029
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (0)
No GO Terms found
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
1
5
84.9
hair color
1
1
0
1.1
61
eosinophil count
2
1
2
53.3
eosinophil percentage of leukocytes
1
1
1
50.6
self reported educational attainment
1
1
1
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
5
84.9
hair color
0
1.1
61
eosinophil count
2
53.3
eosinophil percentage of leukocytes
1
50.6
self reported educational attainment
1
30.2
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ataxin 7 like 1
VGNC:7216
463644
Macaque
ataxin 7 like 1
698666
Mouse
MGI:3584458
380753
Rat
RGD:1305730
362726
Dog
ataxin 7 like 1
VGNC:38304
475892
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ataxin 7 like 1
Macaque
ataxin 7 like 1
Mouse
Rat
Dog
ataxin 7 like 1
Publication Statistics
PubMed Score 1.70
PubMed score by year
PubTator Score 1.70
PubTator score by year
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Related Publications
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PMID
Year
Title