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Tbio
ATXN3
Ataxin-3

Protein Summary
Description
Deubiquitinating enzyme involved in protein homeostasis maintenance, transcription, cytoskeleton regulation, myogenesis and degradation of misfolded chaperone substrates (PubMed:12297501, PubMed:17696782, PubMed:23625928, PubMed:28445460, PubMed:16118278). Binds long polyubiquitin chains and trims them, while it has weak or no activity against chains of 4 or less ubiquitins (PubMed:17696782). Involved in degradation of misfolded chaperone substrates via its interaction with STUB1/CHIP: recruited to monoubiquitinated STUB1/CHIP, and restricts the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension (By similarity). Interacts with key regulators of transcription and represses transcription: acts as a histone-binding protein that regulates transcription (PubMed:12297501). Regulates autophagy via the deubiquitination of 'Lys-402' of BECN1 leading to the stabilization of BECN1 (PubMed:28445460). Machado-Joseph disease, also known as spinocerebel ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340660
  • ENSP00000339110
  • ENSG00000066427
  • ENST00000502250
  • ENSP00000425322
  • ENST00000503767
  • ENSP00000426697
  • ENST00000532032
  • ENSP00000437157
  • ENST00000558190
  • ENSP00000478320
  • ENST00000644486
  • ENSP00000496695

Symbol
  • ATX3
  • MJD
  • MJD1
  • SCA3
  • AT3
  • JOS
  • MJD
  • ATX3
  • MJD1
  • SCA3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
microRNA
0.84
biological process
0.8
virus perturbation
0.79
transcription factor binding site profile
0.78


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 546.15   (req: < 5)
Gene RIFs: 153   (req: <= 3)
Antibodies: 302   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 546.15   (req: >= 5)
Gene RIFs: 153   (req: > 3)
Antibodies: 302   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0