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Tbio
ATXN1L
Ataxin-1-like

Protein Summary
Description
Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression (PubMed:21475249). Can suppress ATXN1 cytotoxicity in spinocerebellar ataxia type 1 (SCA1). In concert with CIC and ATXN1, involved in brain development (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000427980
  • ENSP00000415822
  • ENSG00000224470

Symbol
  • BOAT
  • BOAT1
  • BOAT
  • BOAT1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.86
biological process
0.68
cell type or tissue
0.65
interacting protein
0.6
transcription factor
0.59


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.06   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 81   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.06   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 81   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (32)
CLASRP
Tbio
Novelty:  0.00582947
p_int:  0.999999969
p_ni:  1.9e-8
p_wrong:  1.2e-8
Score:  0.233
Data Source:  BioPlex,STRINGDB
ZBTB18
Tbio
Family:  TF
Novelty:  0.03802355
p_int:  0.999999923
p_ni:  5.5e-8
p_wrong:  2.2e-8
Score:  0.269
Data Source:  BioPlex,STRINGDB
CIC
Tbio
Family:  TF
Novelty:  0.01006338
Score:  0.945
Data Source:  STRINGDB
RBM17
Tbio
Novelty:  0.04840999
Score:  0.767
Data Source:  STRINGDB
ZNF821
Tdark
Family:  TF
Novelty:  0.48571429
Score:  0.742
Data Source:  STRINGDB
BBX
Tbio
Family:  TF
Novelty:  0.02157387
Score:  0.734
Data Source:  STRINGDB
TXNL4B
Tbio
Novelty:  0.00695407
Score:  0.607
Data Source:  STRINGDB
PCP2
Tdark
Novelty:  0.05083955
Score:  0.601
Data Source:  STRINGDB
PQBP1
Tbio
Novelty:  0.01631148
Score:  0.579
Data Source:  STRINGDB
HBP1
Tbio
Family:  TF
Novelty:  0.06312067
Score:  0.576
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (14)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
total cholesterol measurement
3
8
8
95.1
low density lipoprotein cholesterol measurement
3
7
7
94.9
apolipoprotein B measurement
2
7
7
94.1
reticulocyte count
2
1
2
71.2
alcohol consumption measurement
2
2
2
71.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
total cholesterol measurement
8
95.1
low density lipoprotein cholesterol measurement
7
94.9
apolipoprotein B measurement
7
94.1
reticulocyte count
2
71.2
alcohol consumption measurement
2
71.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ataxin 1 like
VGNC:13668
454229
Mouse
MGI:3694797
52335
Rat
RGD:9319286
103694328
Dog
ataxin 1 like
VGNC:38300
489725
Cow
ataxin 1 like
VGNC:26339
521025
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ataxin 1 like
Mouse
Rat
Dog
ataxin 1 like
Cow
ataxin 1 like
Publication Statistics
PubMed Score 10.06
PubMed score by year
PubTator Score 116.38
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title