You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
ATRX
Transcriptional regulator ATRX

Protein Summary
Description
Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embry ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373344
  • ENSP00000362441
  • ENSG00000085224
  • ENST00000395603
  • ENSP00000378967

Symbol
  • RAD54L
  • XH2
  • JMS
  • XH2
  • XNP
  • MRX52
  • RAD54
  • RAD54L
  • ZNF-HX
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
transcription factor perturbation
0.99
biological process
0.97
protein domain
0.97
co-expressed gene
0.94


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 935.48   (req: < 5)
Gene RIFs: 141   (req: <= 3)
Antibodies: 361   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 935.48   (req: >= 5)
Gene RIFs: 141   (req: > 3)
Antibodies: 361   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 37
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (296)
DAXX
Tbio
Novelty:  0.00348585
p_int:  0.999999937
p_ni:  6.2e-8
Score:  0.96
Data Source:  BioPlex,STRINGDB
IMP3
Tbio
Novelty:  0.42681287
p_int:  0.999999852
p_ni:  1.47e-7
p_wrong:  1e-9
Data Source:  BioPlex
HIST1H4A
Tchem
Novelty:  0.00279614
p_int:  0.999997867
p_ni:  0.000002134
Score:  0.493
Data Source:  BioPlex,STRINGDB
WDR1
Tbio
Novelty:  0.01524342
p_int:  0.999181148
p_ni:  0.000573845
p_wrong:  0.000245007
Score:  0.685
Data Source:  BioPlex,STRINGDB
EPB41L3
Tbio
Novelty:  0.00915217
p_int:  0.997801332
p_ni:  0.002198668
Data Source:  BioPlex
HIST1H3A
Tbio
Novelty:  0.00991842
p_int:  0.974721414
p_ni:  0.025277772
p_wrong:  8.13e-7
Score:  0.608
Data Source:  BioPlex,STRINGDB
RAD51
Tchem
Novelty:  0.00011516
Score:  0.962
Data Source:  STRINGDB
MECP2
Tchem
Family:  TF
Novelty:  0.00051767
Score:  0.937
Data Source:  STRINGDB
RAD52
Tchem
Novelty:  0.00125282
Score:  0.914
Data Source:  STRINGDB
BPTF
Tchem
Family:  Epigenetic
Novelty:  0.00826037
Score:  0.897
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (51)
Find Similar Targets
Items per page:
1 – 5 of 51
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Pathways Affected in Adenoid Cystic Carcinoma
WikiPathways
Pathways Affected in Adenoid Cystic Carcinoma
WikiPathways
Pathways Affected in Adenoid Cystic Carcinoma
WikiPathways
Pathways Affected in Adenoid Cystic Carcinoma
WikiPathways
miRNA regulation of prostate cancer signaling pathways
Name
Explore in Pharos
Explore in Source
Pathways Affected in Adenoid Cystic Carcinoma
Pathways Affected in Adenoid Cystic Carcinoma
Pathways Affected in Adenoid Cystic Carcinoma
Pathways Affected in Adenoid Cystic Carcinoma
miRNA regulation of prostate cancer signaling pathways
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (48)
Find Similar Targets
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
1
1
1
68.3
platelet crit
1
1
1
27.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
1
68.3
platelet crit
1
27.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ATRX, chromatin remodeler
VGNC:53808
449625
Macaque
ATRX, chromatin remodeler
705735
Mouse
MGI:103067
22589
Dog
ATRX, chromatin remodeler
VGNC:38297
480963
Cow
ATRX, chromatin remodeler
VGNC:26336
514473
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ATRX, chromatin remodeler
Macaque
ATRX, chromatin remodeler
Mouse
Dog
ATRX, chromatin remodeler
Cow
ATRX, chromatin remodeler
Publication Statistics
PubMed Score 935.48
PubMed score by year
PubTator Score 325.53
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title