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Tbio
ATRX
Transcriptional regulator ATRX

Protein Summary
Description
Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embry ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373344
  • ENSP00000362441
  • ENSG00000085224
  • ENST00000395603
  • ENSP00000378967

Symbol
  • RAD54L
  • XH2
  • JMS
  • XH2
  • XNP
  • MRX52
  • RAD54
  • RAD54L
  • ZNF-HX
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
transcription factor perturbation
0.99
biological process
0.97
protein domain
0.97
co-expressed gene
0.94


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1153.08   (req: < 5)
Gene RIFs: 210   (req: <= 3)
Antibodies: 361   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1153.08   (req: >= 5)
Gene RIFs: 210   (req: > 3)
Antibodies: 361   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 37
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0