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Tbio
ATRIP
ATR-interacting protein

Protein Summary
Description
Required for checkpoint signaling after DNA damage. Required for ATR expression, possibly by stabilizing the protein. This gene encodes an essential component of the DNA damage checkpoint. The encoded protein binds to single-stranded DNA coated with replication protein A. The protein also interacts with the ataxia telangiectasia and Rad3 related protein kinase, resulting in its accumulation at intranuclear foci induced by DNA damage. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000320211
  • ENSP00000323099
  • ENSG00000164053
  • ENST00000346691
  • ENSP00000302338
  • ENST00000357105
  • ENSP00000349620
  • ENST00000412052
  • ENSP00000400930

Symbol
  • AGS1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.72
transcription factor binding site profile
0.63
cellular component
0.61
cell type or tissue
0.56
tissue
0.56


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.06   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 499   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.06   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 499   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (163)
TXLNA
Tbio
Novelty:  0.02549959
p_int:  0.99998523
p_ni:  0.000014396
p_wrong:  3.74e-7
Data Source:  BioPlex
PNKD
Tbio
Family:  Enzyme
Novelty:  0.02456078
p_int:  0.999658071
p_ni:  0.000341927
p_wrong:  2e-9
Data Source:  BioPlex
FZD10
Tbio
Family:  GPCR
Novelty:  0.02786933
p_int:  0.999479821
p_ni:  0.000520177
p_wrong:  3e-9
Data Source:  BioPlex
ST6GAL1
Tchem
Family:  Enzyme
Novelty:  0.00274127
p_int:  0.999473465
p_ni:  0.000526534
p_wrong:  1e-9
Score:  0.167
Data Source:  BioPlex,STRINGDB
JTB
Tbio
Novelty:  0.06646216
p_int:  0.999293445
p_ni:  0.000706517
p_wrong:  3.8e-8
Data Source:  BioPlex
CYB5B
Tbio
Novelty:  0.09395308
p_int:  0.999196362
p_ni:  0.000803389
p_wrong:  2.49e-7
Data Source:  BioPlex
ARL8A
Tbio
Family:  Enzyme
Novelty:  0.12499089
p_int:  0.998626595
p_ni:  0.001372899
p_wrong:  5.06e-7
Data Source:  BioPlex
CD70
Tbio
Novelty:  0.00420393
p_int:  0.997363181
p_ni:  0.002573061
p_wrong:  0.000063759
Data Source:  BioPlex
ATR
Tchem
Family:  Kinase
Novelty:  0.00196978
p_int:  0.995932195
p_ni:  0.004067805
Score:  0.997
Data Source:  BioPlex,Reactome,STRINGDB
KIR3DL2
Tbio
Novelty:  0.00321353
p_int:  0.989198642
p_ni:  0.010799388
p_wrong:  0.00000197
Score:  0.175
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (28)
Activation of ATR in response to replication stress (R-HSA-176187)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 21
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of ATR in response to replication stress
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
DNA Double-Strand Break Repair
Reactome
DNA Repair
Name
Explore in Pharos
Explore in Source
Activation of ATR in response to replication stress
Cell Cycle
Cell Cycle Checkpoints
DNA Double-Strand Break Repair
DNA Repair
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
3
3
3
86.3
mathematical ability
3
2
4
81.6
BMI-adjusted waist circumference
1
2
2
81
BMI-adjusted waist-hip ratio
2
2
2
79.6
macrophage inflammatory protein 1b measurement
1
1
1
74.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
3
86.3
mathematical ability
4
81.6
BMI-adjusted waist circumference
2
81
BMI-adjusted waist-hip ratio
2
79.6
macrophage inflammatory protein 1b measurement
1
74.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ATR interacting protein
VGNC:1744
742205
Macaque
ATR interacting protein
710035
Mouse
MGI:1925349
235610
Rat
RGD:1626390
301014
Dog
ATR interacting protein
VGNC:49885
608504
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ATR interacting protein
Macaque
ATR interacting protein
Mouse
Rat
Dog
ATR interacting protein
Publication Statistics
PubMed Score 59.06
PubMed score by year
PubTator Score 29.20
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title