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Tbio
ATRIP
ATR-interacting protein

Protein Summary
Description
Required for checkpoint signaling after DNA damage. Required for ATR expression, possibly by stabilizing the protein. This gene encodes an essential component of the DNA damage checkpoint. The encoded protein binds to single-stranded DNA coated with replication protein A. The protein also interacts with the ataxia telangiectasia and Rad3 related protein kinase, resulting in its accumulation at intranuclear foci induced by DNA damage. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000320211
  • ENSP00000323099
  • ENSG00000164053
  • ENST00000346691
  • ENSP00000302338
  • ENST00000357105
  • ENSP00000349620
  • ENST00000412052
  • ENSP00000400930

Symbol
  • AGS1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.72
transcription factor binding site profile
0.63
cellular component
0.61
cell type or tissue
0.56
tissue
0.56


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 72.19   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 499   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 72.19   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 499   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0