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Tbio
ATRAID
All-trans retinoic acid-induced differentiation factor

Protein Summary
Description
Promotes osteoblast cell differentiation and terminal mineralization. Plays a role in inducing the cell cycle arrest via inhibiting CCND1 expression in all-trans-retinoic acid (ATRA) signal pathway. This gene is thought to be involved in apoptosis, and may also be involved in hematopoietic development and differentiation. The use of alternative splice sites and promotors result in multiple transcript variants encoding different isoforms.[provided by RefSeq, Dec 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380171
  • ENSP00000369518
  • ENSG00000138085
  • ENST00000405489
  • ENSP00000384033
  • ENST00000606999
  • ENSP00000476080
  • ENST00000611786
  • ENSP00000484228

Symbol
  • APR3
  • C2orf28
  • p18
  • APR3
  • APR-3
  • APR--3
  • PRO240
  • C2orf28
  • HSPC013
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.96
kinase perturbation
0.84
cell type or tissue
0.83
transcription factor binding site profile
0.76
histone modification site profile
0.73


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.29   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 97   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.29   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 97   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0