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Tbio
ATP8B2
Phospholipid-transporting ATPase ID

Protein Summary
Description
Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable). The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of aminophospholipid-transporting ATPases. The aminophospholipid translocases transport phosphatidylserine and phosphatidylethanolamine from one side of a bilayer to another. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368487
  • ENSP00000357472
  • ENSG00000143515
  • ENST00000368489
  • ENSP00000357475

Symbol
  • ATPID
  • KIAA1137
  • ATPID
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
metabolite
0.98
kinase perturbation
0.95
protein domain
0.92
histone modification site profile
0.86


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.14   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 90   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.14   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 90   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (35)
YIPF3
Tbio
Novelty:  0.12021667
p_int:  0.999833645
p_ni:  0.000166355
Data Source:  BioPlex
CLEC2D
Tbio
Novelty:  0.02501194
p_int:  0.997592935
p_ni:  0.002407065
Data Source:  BioPlex
KITLG
Tbio
Novelty:  0.00036337
p_int:  0.985642839
p_ni:  0.014357161
Score:  0.534
Data Source:  BioPlex,STRINGDB
CHCHD10
Tbio
Novelty:  0.01659548
p_int:  0.963220865
p_ni:  0.036779135
Data Source:  BioPlex
RXFP1
Tchem
Family:  GPCR
Novelty:  0.00580827
p_int:  0.958207844
p_ni:  0.041792071
p_wrong:  8.5e-8
Score:  0.23
Data Source:  BioPlex,STRINGDB
TIGIT
Tbio
Novelty:  0.0064542
p_int:  0.940682069
p_ni:  0.059317893
p_wrong:  3.8e-8
Data Source:  BioPlex
CD79B
Tclin
Novelty:  0.00227414
p_int:  0.934400382
p_ni:  0.065599618
Data Source:  BioPlex
KLRD1
Tbio
Novelty:  0.00218019
p_int:  0.925880819
p_ni:  0.074118204
p_wrong:  9.77e-7
Data Source:  BioPlex
MCOLN3
Tchem
Family:  IC
Novelty:  0.03209262
p_int:  0.919223981
p_ni:  0.080776019
Data Source:  BioPlex
TMED2
Tbio
Novelty:  0.03731104
p_int:  0.911591678
p_ni:  0.088408322
Score:  0.203
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Ion channel transport (R-HSA-983712)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Ion channel transport
Reactome
Ion transport by P-type ATPases
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Ion channel transport
Ion transport by P-type ATPases
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (24)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
6
14
17
11.5
99.9
interleukin-6 measurement
3
3
3
97.6
mean corpuscular hemoglobin concentration
2
2
2
89.3
alkaline phosphatase measurement
2
1
1
11.7
85.5
6
3
3
1.1
83.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
17
11.5
99.9
interleukin-6 measurement
3
97.6
mean corpuscular hemoglobin concentration
2
89.3
alkaline phosphatase measurement
1
11.7
85.5
3
1.1
83.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ATPase phospholipid transporting 8B2
VGNC:8034
469505
Macaque
ATPase phospholipid transporting 8B2
716652
Mouse
MGI:1859660
54667
Rat
RGD:1597731
685152
Dog
ATPase phospholipid transporting 8B2
VGNC:38289
490447
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ATPase phospholipid transporting 8B2
Macaque
ATPase phospholipid transporting 8B2
Mouse
Rat
Dog
ATPase phospholipid transporting 8B2
Publication Statistics
PubMed Score 9.14
PubMed score by year
PubTator Score 1.58
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title