Tbio ATP6V1G1 V-type proton ATPase subunit G 1

Protein Summary

Description

Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (PubMed:28296633). This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. The protein encoded by this gene is one of three V1 domain G subunit proteins. Pseudogenes of this gene have been characterized. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O75348
• Q6IB33
• V-ATPase subunit G 1

Gene Name

• ATP6V1G1

Ensembl ID

• ENST00000374050
• ENSP00000363162
• ENSG00000136888

Symbol

• ATP6G
• ATP6G1
• ATP6J
• ATP6G
• ATP6J
• Vma10
• ATP6G1
• ATP6GL

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.96
kinase perturbation	0.93
disease perturbation	0.87
virus perturbation	0.85
interacting protein	0.74

Protein Classes

PANTHER Classes

Protein / Transporter / Cation Transporter / Atp Synthase / V-type Proton Atpase Subunit G 1

Protein / Hydrolase / V-type Proton Atpase Subunit G 1

DTO Classes

Protein / Transporter / F-type And V-type Atpases / V-type Atpase / V-type Proton Atpase Subunit G 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.1   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 140   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.1   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 140   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0