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Tbio
ATP6V1G1
V-type proton ATPase subunit G 1

Protein Summary
Description
Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (PubMed:28296633). This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. T ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374050
  • ENSP00000363162
  • ENSG00000136888

Symbol
  • ATP6G
  • ATP6G1
  • ATP6J
  • ATP6G
  • ATP6J
  • Vma10
  • ATP6G1
  • ATP6GL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
kinase perturbation
0.93
disease perturbation
0.87
virus perturbation
0.85
interacting protein
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.72   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 140   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.72   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 140   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (81)
ATP6V1D
Tbio
Family:  Enzyme
Novelty:  0.02298626
p_int:  0.999273685
p_ni:  0.000726315
Score:  0.997
Data Source:  BioPlex,STRINGDB
KLHL18
Tdark
Novelty:  0.52915213
p_int:  0.998206889
p_ni:  0.001791809
p_wrong:  0.000001302
Score:  0.187
Data Source:  BioPlex,STRINGDB
LACC1
Tbio
Family:  Enzyme
Novelty:  0.03928871
p_int:  0.997257219
p_ni:  0.002727455
p_wrong:  0.000015326
Data Source:  BioPlex
ATP6V1B1
Tchem
Family:  Enzyme
Novelty:  0.01122589
p_int:  0.977317357
p_ni:  0.022682643
Score:  0.998
Data Source:  BioPlex,STRINGDB
ATP6V1C2
Tbio
Family:  Enzyme
Novelty:  0.07583427
p_int:  0.954827851
p_ni:  0.045172147
p_wrong:  3e-9
Score:  0.998
Data Source:  BioPlex,STRINGDB
BTBD9
Tbio
Novelty:  0.02793632
p_int:  0.821743381
p_ni:  0.178256618
Score:  0.189
Data Source:  BioPlex,STRINGDB
CARM1
Tchem
Family:  Epigenetic
Novelty:  0.00623937
p_int:  0.758149038
p_ni:  0.241850962
Score:  0.179
Data Source:  BioPlex,STRINGDB
ATP6V1F
Tbio
Family:  Enzyme
Novelty:  0.07109314
Score:  0.998
Data Source:  STRINGDB
ATP6V1E2
Tbio
Family:  Enzyme
Novelty:  0.10447007
Score:  0.998
Data Source:  STRINGDB
ATP6V1E1
Tbio
Family:  Enzyme
Novelty:  0.04832113
Score:  0.997
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (22)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Insulin receptor recycling
Reactome
Ion channel transport
Reactome
Iron uptake and transport
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Insulin receptor recycling
Ion channel transport
Iron uptake and transport
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
depressive episode measurement
1
1
1
1.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
depressive episode measurement
1
1.4
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ATPase H+ transporting V1 subunit G1
VGNC:13855
473030
Mouse
MGI:1913540
66290
Rat
RGD:1310088
298103
Horse
ATPase H+ transporting V1 subunit G1 [Source:HGNC Symbol;Acc:HGNC:864]
Cow
ATPase H+ transporting V1 subunit G1
VGNC:26324
281641
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ATPase H+ transporting V1 subunit G1
Mouse
Rat
Horse
ATPase H+ transporting V1 subunit G1 [Source:HGNC Symbol;Acc:HGNC:864]
Cow
ATPase H+ transporting V1 subunit G1
Publication Statistics
PubMed Score 11.72
PubMed score by year
PubTator Score 3.62
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title