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Tbio
ATP6V1F
V-type proton ATPase subunit F

Protein Summary
Description
Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript varian ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000249289
  • ENSP00000249289
  • ENSG00000128524
  • ENST00000492758
  • ENSP00000417378

Symbol
  • ATP6S14
  • VATF
  • VATF
  • Vma7
  • ATP6S14
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.95
kinase perturbation
0.88
co-expressed gene
0.82
disease perturbation
0.79
transcription factor binding site profile
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.1   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 178   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.1   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 178   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (113)
ATP6V1C2
Tbio
Family:  Enzyme
Novelty:  0.07583427
p_int:  0.999980476
p_ni:  0.000019524
Score:  0.998
Data Source:  BioPlex,STRINGDB
ATP6V1B1
Tchem
Family:  Enzyme
Novelty:  0.01122589
p_int:  0.999975192
p_ni:  0.000024808
Score:  0.998
Data Source:  BioPlex,STRINGDB
ATP6V1D
Tbio
Family:  Enzyme
Novelty:  0.02298626
p_int:  0.999435435
p_ni:  0.000564565
Score:  0.999
Data Source:  BioPlex,STRINGDB
KIAA2013
Tdark
Novelty:  0.4705158
p_int:  0.935238336
p_ni:  0.064761662
p_wrong:  2e-9
Score:  0.819
Data Source:  BioPlex,STRINGDB
ATP6AP2
Tbio
Novelty:  0.00357665
p_int:  0.917906704
p_ni:  0.082093296
Score:  0.944
Data Source:  BioPlex,STRINGDB
ATP6V0A2
Tbio
Family:  Enzyme
Novelty:  0.00504614
p_int:  0.910710188
p_ni:  0.089289812
Score:  0.998
Data Source:  BioPlex,STRINGDB
TRIM11
Tbio
Family:  Enzyme
Novelty:  0.02243955
p_int:  0.900737014
p_ni:  0.099262986
Score:  0.154
Data Source:  BioPlex,STRINGDB
PLXDC2
Tbio
Novelty:  0.06496695
p_int:  0.899560001
p_ni:  0.100439999
Score:  0.181
Data Source:  BioPlex,STRINGDB
ATP6V0D1
Tbio
Family:  Enzyme
Novelty:  0.05146108
p_int:  0.865147236
p_ni:  0.134837767
p_wrong:  0.000014996
Score:  0.998
Data Source:  BioPlex,STRINGDB
ATP6V1H
Tbio
Family:  Enzyme
Novelty:  0.04269105
Score:  0.999
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (21)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Insulin receptor recycling
Reactome
Ion channel transport
Reactome
Iron uptake and transport
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Insulin receptor recycling
Ion channel transport
Iron uptake and transport
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (15)
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Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Non-traceable Author Statement (NAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (26)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
13
9
0
1.7
99.3
5
5
2
1.2
86.2
eosinophil count
2
2
2
83.2
5
3
0
1.5
80.9
2
2
0
1.5
75.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.7
99.3
2
1.2
86.2
eosinophil count
2
83.2
0
1.5
80.9
0
1.5
75.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ATPase H+ transporting V1 subunit F
740972
Mouse
MGI:1913394
66144
Rat
RGD:621552
116664
Dog
ATPase H+ transporting V1 subunit F
VGNC:38282
475199
Cow
ATPase H+ transporting V1 subunit F
282405
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ATPase H+ transporting V1 subunit F
Mouse
Rat
Dog
ATPase H+ transporting V1 subunit F
Cow
ATPase H+ transporting V1 subunit F
Publication Statistics
PubMed Score 14.10
PubMed score by year
PubTator Score 2.67
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title