Tbio ATP6V1E2 V-type proton ATPase subunit E 2

Protein Summary

Description

Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. This isoform is essential for energy coupling involved in acidification of acrosome (By similarity).

Uniprot Accession IDs

• Q96A05
• V-ATPase subunit E 2

Gene Name

• ATP6V1E2

Ensembl ID

• ENST00000306448
• ENSP00000304891
• ENSG00000250565
• ENST00000522587
• ENSP00000428141

Symbol

• ATP6E1
• ATP6EL2
• ATP6V1EL2
• VMA4
• ATP6E1
• ATP6EL2
• ATP6V1EL2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.96
virus perturbation	0.92
tissue sample	0.61
cell type or tissue	0.57
tissue	0.57

Protein Classes

DTO Classes

Protein / Transporter / F-type And V-type Atpases / V-type Atpase / V-type Proton Atpase Subunit E 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.68   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 91   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.68   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 91   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0