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Tbio
ATP6V1E1
V-type proton ATPase subunit E 1

Protein Summary
Description
Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. This gene encodes alternate transcriptional splice variants, encoding different V1 domain E subunit isoforms. Pseudogenes for this gene have been found in the genome. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000253413
  • ENSP00000253413
  • ENSG00000131100
  • ENST00000399796
  • ENSP00000382694
  • ENST00000399798
  • ENSP00000382696

Symbol
  • ATP6E
  • ATP6E2
  • P31
  • Vma4
  • ATP6E
  • ARCL2C
  • ATP6E2
  • ATP6V1E
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
1
molecular function
0.97
interacting protein
0.91
hub protein
0.82


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.19   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 174   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.19   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 174   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (117)
ATP6V1B1
Tchem
Family:  Enzyme
Novelty:  0.01122589
p_int:  0.99999923
p_ni:  7.7e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
ATP6V1C2
Tbio
Family:  Enzyme
Novelty:  0.07583427
p_int:  0.999998952
p_ni:  0.000001048
Score:  0.998
Data Source:  BioPlex,STRINGDB
ATP6V1D
Tbio
Family:  Enzyme
Novelty:  0.02298626
p_int:  0.999986729
p_ni:  0.000013271
Score:  0.999
Data Source:  BioPlex,STRINGDB
ATP6V0A2
Tbio
Family:  Enzyme
Novelty:  0.00504614
p_int:  0.998538397
p_ni:  0.001461603
Score:  0.992
Data Source:  BioPlex,STRINGDB
TLDC2
Tdark
Novelty:  0.76180627
p_int:  0.991124364
p_ni:  0.008875636
Score:  0.385
Data Source:  BioPlex,STRINGDB
PSG9
Tbio
Novelty:  0.0426075
p_int:  0.970167667
p_ni:  0.029832333
Score:  0.198
Data Source:  BioPlex,STRINGDB
ATP6AP2
Tbio
Novelty:  0.00357665
p_int:  0.84418757
p_ni:  0.155812427
p_wrong:  3e-9
Score:  0.735
Data Source:  BioPlex,STRINGDB
ATP6V1B2
Tchem
Family:  Enzyme
Novelty:  0.01767911
Score:  0.999
Data Source:  STRINGDB
ATP6V1H
Tbio
Family:  Enzyme
Novelty:  0.04269105
Score:  0.999
Data Source:  STRINGDB
ATP6V1F
Tbio
Family:  Enzyme
Novelty:  0.07109314
Score:  0.999
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (22)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Insulin receptor recycling
Reactome
Ion channel transport
Reactome
Iron uptake and transport
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Insulin receptor recycling
Ion channel transport
Iron uptake and transport
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
3
3
3
92.7
leukocyte count
1
1
1
73
lymphocyte percentage of leukocytes
1
1
1
67.1
eosinophil count
2
1
2
63.4
neutrophil percentage of leukocytes
1
1
1
53.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
3
92.7
leukocyte count
1
73
lymphocyte percentage of leukocytes
1
67.1
eosinophil count
2
63.4
neutrophil percentage of leukocytes
1
53.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
ATPase H+ transporting V1 subunit E1
709739
Mouse
MGI:894326
11973
Rat
RGD:735157
297566
Dog
ATPase H+ transporting V1 subunit E1
477740
Horse
ATPase H+ transporting V1 subunit E1
VGNC:15681
100049854
Species
Name
OMA
EggNOG
Inparanoid
Macaque
ATPase H+ transporting V1 subunit E1
Mouse
Rat
Dog
ATPase H+ transporting V1 subunit E1
Horse
ATPase H+ transporting V1 subunit E1
Publication Statistics
PubMed Score 18.19
PubMed score by year
PubTator Score 196.38
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title