Tchem ATP6V1B2 V-type proton ATPase subunit B, brain isoform

Protein Summary

Description

Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. The protein encoded by this gene is one of two V1 domain B subunit isoforms and is the only B isoform highly expressed in osteoclasts. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P21281
• B2R5Z3
• D3DSQ5
• Q14544
• Q15859
• Q96IR0
• V-ATPase subunit B 2

Gene Name

• ATP6V1B2

Ensembl ID

• ENST00000276390
• ENSP00000276390
• ENSG00000147416

Symbol

• ATP6B2
• VPP3
• DOOD
• HO57
• VATB
• VPP3
• Vma2
• ZLS2
• ATP6B2
• ATP6B1B2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
interacting protein	1
molecular function	1
transcription factor perturbation	0.99
protein domain	0.92

Protein Classes

PANTHER Classes

Protein / Transporter / Ion Channel / Ligand-gated Ion Channel / V-type Proton Atpase Subunit B, Brain Isoform

Protein / Transporter / Ion Channel / Anion Channel / V-type Proton Atpase Subunit B, Brain Isoform

Protein / Transporter / Cation Transporter / Atp Synthase / V-type Proton Atpase Subunit B, Brain Isoform

Protein / Receptor / Ligand-gated Ion Channel / V-type Proton Atpase Subunit B, Brain Isoform

Protein / Nucleic Acid Binding / Dna Binding Protein / V-type Proton Atpase Subunit B, Brain Isoform

Protein / Hydrolase / V-type Proton Atpase Subunit B, Brain Isoform

DTO Classes

Protein / Transporter / F-type And V-type Atpases / V-type Atpase / V-type Proton Atpase Subunit B, Brain Isoform

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.61   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 220   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.61   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 220   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

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No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (1)

Explore Active Ligands

1 – 1 of 1

enoxacin

ATP6V1B2Tchem Enzyme

pIC50 : 5

Protein-Protein Interactions (104)

Explore Interacting Targets

1 – 10 of 104

• See Interactions on String-DB

ATP6V1B1

Tchem

Family:  Enzyme

Novelty:  0.01122589

p_int:  0.999996342

p_ni:  0.000003658

Score:  0.964

Data Source:  BioPlex,Reactome,STRINGDB

ATP6V1C2

Tbio

Family:  Enzyme

Novelty:  0.07583427

p_int:  0.999972141

p_ni:  0.000027859

Score:  0.999

Data Source:  BioPlex,STRINGDB

ATP6V1D

Tbio

Family:  Enzyme

Novelty:  0.02298626

p_int:  0.999723483

p_ni:  0.000276517

Score:  0.999

Data Source:  BioPlex,STRINGDB

TLDC2

Tdark

Novelty:  0.76180627

p_int:  0.963947773

p_ni:  0.036052227

Score:  0.282

Data Source:  BioPlex,STRINGDB

ATP6V0A2

Tbio

Family:  Enzyme

Novelty:  0.00504614

p_int:  0.953497851

p_ni:  0.046502149

Score:  0.994

Data Source:  BioPlex,STRINGDB

ATP6V1A

Tbio

Family:  Enzyme

Novelty:  0.00921474

Score:  0.999

Data Source:  STRINGDB

ATP6V1E1

Tbio

Family:  Enzyme

Novelty:  0.04832113

Score:  0.999

Data Source:  STRINGDB

ATP6V1F

Tbio

Family:  Enzyme

Novelty:  0.07109314

Score:  0.999

Data Source:  STRINGDB

ATP6V1H

Tbio

Family:  Enzyme

Novelty:  0.04269105

Score:  0.999

Data Source:  STRINGDB

ATP6V0D1

Tbio

Family:  Enzyme

Novelty:  0.05146108

Score:  0.998

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (21)

Reactome (11)

KEGG (10)

Immune System (R-HSA-168256)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Immune System	2246 targets	R-HSA-168256
Reactome	Innate Immune System	1188 targets	R-HSA-168249
Reactome	Insulin receptor recycling	26 targets	R-HSA-77387
Reactome	Ion channel transport	179 targets	R-HSA-983712
Reactome	Iron uptake and transport	59 targets	R-HSA-917937

Name	Explore in Pharos	Explore in Source
Immune System	2246 targets	R-HSA-168256
Innate Immune System	1188 targets	R-HSA-168249
Insulin receptor recycling	26 targets	R-HSA-77387
Ion channel transport	179 targets	R-HSA-983712
Iron uptake and transport	59 targets	R-HSA-917937

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (22)

Functions (3)

Components (12)

Processes (7)

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1 – 3 of 3

GO Term	Evidence	Assigned by
proton transmembrane transporter activity	Traceable Author Statement (TAS)	ProtInc
proton-transporting ATPase activity, rotational mechanism	Traceable Author Statement (TAS)	ProtInc
ATP binding	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations (null)

No disease associations found

GWAS Traits (5)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
triglyceride measurement	EFO_0004530	3	6	8		98.6
high density lipoprotein cholesterol measurement	EFO_0004612	2	8	8		98.3
apolipoprotein A 1 measurement	EFO_0004614	2	5	5		93.4
apolipoprotein B measurement	EFO_0004615	1	2	2		45.5
sleep duration	EFO_0005271	1	1	1		7.6

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
triglyceride measurement	EFO_0004530	8		98.6
high density lipoprotein cholesterol measurement	EFO_0004612	8		98.3
apolipoprotein A 1 measurement	EFO_0004614	5		93.4
apolipoprotein B measurement	EFO_0004615	2		45.5
sleep duration	EFO_0005271	1		7.6

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UniProt Keyword Find Similar Targets

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Complete proteome
Deafness
Disease mutation
Hydrogen ion transport
Hydrolase
Ion transport
Membrane
Reference proteome
Transport

GWAS Trait Find Similar Targets

No Header	No Header
apolipoprotein A 1 measurement
apolipoprotein B measurement
high density lipoprotein cholesterol measurement
sleep duration
triglyceride measurement

MGI Phenotype Find Similar Targets

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endocrine/exocrine gland phenotype
hematopoietic system phenotype
immune system phenotype
mortality/aging

IDG Resources

No IDG generated resources found

Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	ATPase H+ transporting V1 subunit B2	VGNC:11958	464033
Macaque	ATPase H+ transporting V1 subunit B2		705605
Mouse	ATPase, H+ transporting, lysosomal V1 subunit B2	MGI:109618	11966
Rat	ATPase H+ transporting V1 subunit B2	RGD:620284	117596
Dog	ATPase H+ transporting V1 subunit B2	VGNC:38277	486137

Species	Name	OMA	EggNOG	Inparanoid
Chimp	ATPase H+ transporting V1 subunit B2
Macaque	ATPase H+ transporting V1 subunit B2
Mouse	ATPase, H+ transporting, lysosomal V1 subunit B2
Rat	ATPase H+ transporting V1 subunit B2
Dog	ATPase H+ transporting V1 subunit B2

Publication Statistics

PubMed Score 59.61

PubMed score by year

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PubTator Score 9.85

PubTator score by year

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Related Publications

Text Mined References (40)

GeneRif Annotations (8)

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PMID	Year	Title