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Tchem
ATP6V1B1
V-type proton ATPase subunit B, kidney isoform

Protein Summary
Description
Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is on ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000234396
  • ENSP00000234396
  • ENSG00000116039

Symbol
  • ATP6B1
  • VATB
  • VPP3
  • VATB
  • VMA2
  • VPP3
  • RTA1B
  • ATP6B1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
protein domain
0.92
hub protein
0.9
gene perturbation
0.89
biological process
0.82


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 92.97   (req: < 5)
Gene RIFs: 26   (req: <= 3)
Antibodies: 337   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 92.97   (req: >= 5)
Gene RIFs: 26   (req: > 3)
Antibodies: 337   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (99)
ATP6V1C1
Tbio
Family:  Enzyme
Novelty:  0.03660846
p_int:  0.999999997
p_ni:  3e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
NCOA7
Tbio
Novelty:  0.08842763
p_int:  0.999999987
p_ni:  1e-8
p_wrong:  3e-9
Score:  0.408
Data Source:  BioPlex,STRINGDB
ATP6V1D
Tbio
Family:  Enzyme
Novelty:  0.02298626
p_int:  0.999999932
p_ni:  6.8e-8
Score:  0.999
Data Source:  BioPlex,STRINGDB
ATP6V1E2
Tbio
Family:  Enzyme
Novelty:  0.10447007
p_int:  0.999999895
p_wrong:  1.05e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
ATP6V1E1
Tbio
Family:  Enzyme
Novelty:  0.04832113
p_int:  0.99999923
p_ni:  7.7e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
DMXL1
Tdark
Novelty:  0.0234264
p_int:  0.999998849
p_ni:  0.000001129
p_wrong:  2.2e-8
Score:  0.902
Data Source:  BioPlex,STRINGDB
ATP6V1G2
Tbio
Family:  Enzyme
Novelty:  0.10663259
p_int:  0.999998713
p_ni:  0.000001255
p_wrong:  3.2e-8
Score:  0.998
Data Source:  BioPlex,STRINGDB
WDR7
Tdark
Novelty:  0.00602015
p_int:  0.999996756
p_ni:  0.000003244
p_wrong:  1e-9
Score:  0.33
Data Source:  BioPlex,STRINGDB
ATP6V1B2
Tchem
Family:  Enzyme
Novelty:  0.01767911
p_int:  0.999996342
p_ni:  0.000003658
Score:  0.964
Data Source:  BioPlex,Reactome,STRINGDB
ATP6V1F
Tbio
Family:  Enzyme
Novelty:  0.07109314
p_int:  0.999975192
p_ni:  0.000024808
Score:  0.998
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (21)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Insulin receptor recycling
Reactome
Ion channel transport
Reactome
Iron uptake and transport
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Insulin receptor recycling
Ion channel transport
Iron uptake and transport
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
1
1
1
26.6
eosinophil count
2
1
2
21.4
eosinophil percentage of leukocytes
1
1
1
13.8
1
1
0
1.1
1.9
gut microbiome measurement
1
1
0
5.6
1.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
1
26.6
eosinophil count
2
21.4
eosinophil percentage of leukocytes
1
13.8
0
1.1
1.9
gut microbiome measurement
0
5.6
1.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ATPase H+ transporting V1 subunit B1
VGNC:10563
470401
Macaque
ATPase H+ transporting V1 subunit B1
703646
Mouse
MGI:103285
110935
Rat
RGD:1310619
312488
Dog
ATPase H+ transporting V1 subunit B1
VGNC:54276
474628
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ATPase H+ transporting V1 subunit B1
Macaque
ATPase H+ transporting V1 subunit B1
Mouse
Rat
Dog
ATPase H+ transporting V1 subunit B1
Publication Statistics
PubMed Score 92.97
PubMed score by year
PubTator Score 42.22
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title