Tbio ATP6V0A2 V-type proton ATPase 116 kDa subunit a isoform 2

Protein Summary

Description

Part of the proton channel of V-ATPases. Essential component of the endosomal pH-sensing machinery. May play a role in maintaining the Golgi functions, such as glycosylation maturation, by controlling the Golgi pH. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (PubMed:28296633). The protein encoded by this gene is a subunit of the vacuolar ATPase (v-ATPase), an heteromultimeric enzyme that is present in intracellular vesicles and in the plasma membrane of specialized cells, and which is essential for the acidification of diverse cellular components. V-ATPase is comprised of a membrane peripheral V(1) domain for ATP hydrolysis, and an integral membrane V(0) domain for proton translocation. The subunit encoded by this gene is a component of the V(0) domain. Mutations in this gene are a cause of both cutis laxa type II and wrinkly skin syndrome. [provided by RefSeq, Jul 2009]

Uniprot Accession IDs

• Q9Y487
• A8K026
• Q6NUM0
• V-ATPase 116 kDa isoform a2

Gene Name

• ATP6V0A2

Ensembl ID

• ENST00000330342
• ENSP00000332247
• ENSG00000185344

Symbol

• A2
• RTF
• TJ6
• WSS
• ARCL
• J6B7
• STV1
• TJ6M
• TJ6S
• VPH1
• ARCL2A
• ATP6A2
• ATP6N1D

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	1
molecular function	0.96
kinase perturbation	0.95
virus perturbation	0.95
biological process	0.93

Protein Classes

PANTHER Classes

Protein / Transporter / Cation Transporter / Atp Synthase / V-type Proton Atpase 116 Kda Subunit A Isoform 2

Protein / Hydrolase / V-type Proton Atpase 116 Kda Subunit A Isoform 2

DTO Classes

Protein / Transporter / F-type And V-type Atpases / V-type Atpase / V-type Proton Atpase 116 Kda Subunit A Isoform 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 271.33   (req: < 5)

Gene RIFs: 24   (req: <= 3)

Antibodies: 103   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 271.33   (req: >= 5)

Gene RIFs: 24   (req: > 3)

Antibodies: 103   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0