You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
ATP5PF
ATP synthase-coupling factor 6, mitochondrial

Protein Summary
Description
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. Also involved in the restoration of oligomycin-sensitive ATPase activity to depleted F1-F0 complexes. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the i ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000284971
  • ENSP00000284971
  • ENSG00000154723
  • ENST00000400087
  • ENSP00000382959
  • ENST00000400090
  • ENSP00000382962
  • ENST00000400093
  • ENSP00000382965
  • ENST00000400094
  • ENSP00000382966
  • ENST00000457143
  • ENSP00000389649

Symbol
  • ATP5A
  • ATP5J
  • ATPM
  • F6
  • CF6
  • ATP5
  • ATPM
  • ATP5A
  • ATP5J
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 184.25   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 192   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 184.25   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 192   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (235)
DNAJC28
Tbio
Novelty:  0.02849281
p_int:  0.999999791
p_ni:  5.7e-8
p_wrong:  1.51e-7
Data Source:  BioPlex
MT-ATP8
Tbio
Family:  Enzyme
Novelty:  0.00249065
p_int:  0.999969981
p_ni:  0.000030008
p_wrong:  1.2e-8
Score:  0.915
Data Source:  BioPlex,STRINGDB
TMEM120A
Tdark
Novelty:  0.21664358
p_int:  0.999753277
p_ni:  0.000242391
p_wrong:  0.000004332
Data Source:  BioPlex
ATP5ME
Tbio
Family:  Enzyme
Novelty:  0.12559724
p_int:  0.99971306
p_ni:  0.00028694
Score:  0.999
Data Source:  BioPlex,STRINGDB
ATP5MG
Tbio
Family:  Enzyme
Novelty:  0.16555751
p_int:  0.999608209
p_ni:  0.000391791
Score:  0.995
Data Source:  BioPlex,STRINGDB
ATP5PD
Tbio
Family:  Enzyme
Novelty:  0.0730514
p_int:  0.999409008
p_ni:  0.000590992
Score:  0.999
Data Source:  BioPlex,STRINGDB
ATP5F1A
Tbio
Family:  Enzyme
Novelty:  0.01052213
p_int:  0.999353409
p_ni:  0.000646591
Score:  0.994
Data Source:  BioPlex,STRINGDB
ATP5F1C
Tbio
Family:  Enzyme
Novelty:  0.07666564
p_int:  0.998314656
p_ni:  0.001685344
Score:  0.993
Data Source:  BioPlex,STRINGDB
ATP5PO
Tbio
Family:  Enzyme
Novelty:  0.01038964
p_int:  0.997067452
p_ni:  0.002932548
Score:  0.999
Data Source:  BioPlex,STRINGDB
PEX13
Tbio
Novelty:  0.01777214
p_int:  0.994860253
p_ni:  0.002188502
p_wrong:  0.002951245
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (17)
Cristae formation (R-HSA-8949613)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cristae formation
Reactome
Formation of ATP by chemiosmotic coupling
Reactome
Metabolism
Reactome
Mitochondrial biogenesis
Reactome
Organelle biogenesis and maintenance
Name
Explore in Pharos
Explore in Source
Cristae formation
Formation of ATP by chemiosmotic coupling
Metabolism
Mitochondrial biogenesis
Organelle biogenesis and maintenance
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ATP synthase peripheral stalk subunit F6
744512
Macaque
ATP synthase peripheral stalk subunit F6
708411
Mouse
MGI:107777
11957
Dog
ATP synthase peripheral stalk subunit F6
VGNC:38265
478393
Horse
ATP synthase peripheral stalk subunit F6
VGNC:15663
100066379
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ATP synthase peripheral stalk subunit F6
Macaque
ATP synthase peripheral stalk subunit F6
Mouse
Dog
ATP synthase peripheral stalk subunit F6
Horse
ATP synthase peripheral stalk subunit F6
Publication Statistics
PubMed Score 184.25
PubMed score by year
PubTator Score 125.55
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title