You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
ATP5PD
ATP synthase subunit d, mitochondrial

Protein Summary
Description
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. It is composed of two linked multi-subunit complexes: ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000301587
  • ENSP00000301587
  • ENSG00000167863
  • ENST00000344546
  • ENSP00000344230

Symbol
  • ATP5H
  • ATPQ
  • APT5H
  • ATP5H
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.63   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 229   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.63   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 229   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (271)
ATP5PF
Tbio
Family:  Enzyme
Novelty:  0.00585408
p_int:  0.999409008
p_ni:  0.000590992
Score:  0.999
Data Source:  BioPlex,STRINGDB
ATP5F1B
Tbio
Family:  Enzyme
Novelty:  0.01053177
p_int:  0.99816696
p_ni:  0.001833037
p_wrong:  3e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
ATP5F1D
Tbio
Family:  Enzyme
Novelty:  0.07296539
p_int:  0.986857169
p_ni:  0.013142467
p_wrong:  3.64e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
ATP5PB
Tbio
Family:  Enzyme
Novelty:  0.07345384
p_int:  0.940312658
p_ni:  0.059687342
Score:  0.999
Data Source:  BioPlex,STRINGDB
DKK3
Tbio
Novelty:  0.00519275
p_int:  0.891488292
p_ni:  0.108511668
p_wrong:  4.1e-8
Data Source:  BioPlex
ZFYVE27
Tbio
Novelty:  0.0563358
p_int:  0.852036075
p_ni:  0.147963924
p_wrong:  2e-9
Score:  0.71
Data Source:  BioPlex,STRINGDB
TACR1
Tclin
Family:  GPCR
Novelty:  0.00062762
p_int:  0.774811548
p_ni:  0.225188452
Score:  0.532
Data Source:  BioPlex,STRINGDB
P2RY12
Tclin
Family:  GPCR
Novelty:  0.00035406
p_int:  0.76944434
p_ni:  0.230555659
Score:  0.541
Data Source:  BioPlex,STRINGDB
ATP5ME
Tbio
Family:  Enzyme
Novelty:  0.12559724
Score:  0.999
Data Source:  STRINGDB
ATP5MG
Tbio
Family:  Enzyme
Novelty:  0.16555751
Score:  0.999
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (15)
Cristae formation (R-HSA-8949613)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cristae formation
Reactome
Formation of ATP by chemiosmotic coupling
Reactome
Metabolism
Reactome
Mitochondrial biogenesis
Reactome
Organelle biogenesis and maintenance
Name
Explore in Pharos
Explore in Source
Cristae formation
Formation of ATP by chemiosmotic coupling
Metabolism
Mitochondrial biogenesis
Organelle biogenesis and maintenance
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
1
1
1
66.3
ferritin measurement
1
1
1
55.2
lymphocyte percentage of leukocytes
2
2
2
55.2
C-reactive protein measurement
1
1
1
46.9
neutrophil percentage of leukocytes
2
1
2
10
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
1
66.3
ferritin measurement
1
55.2
lymphocyte percentage of leukocytes
2
55.2
C-reactive protein measurement
1
46.9
neutrophil percentage of leukocytes
2
10
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ATP synthase peripheral stalk subunit d
VGNC:9225
736468
Macaque
ATP synthase peripheral stalk subunit d
700338
Horse
ATP synthase peripheral stalk subunit d
VGNC:15662
100052170
Cow
ATP synthase peripheral stalk subunit d
282710
Opossum
ATP synthase peripheral stalk subunit d
100023278
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ATP synthase peripheral stalk subunit d
Macaque
ATP synthase peripheral stalk subunit d
Horse
ATP synthase peripheral stalk subunit d
Cow
ATP synthase peripheral stalk subunit d
Opossum
ATP synthase peripheral stalk subunit d
Publication Statistics
PubMed Score 11.63
PubMed score by year
PubTator Score 1.92
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title