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Tbio
ATP5MF
ATP synthase subunit f, mitochondrial

Protein Summary
Description
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, which comprises the proton ch ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000292475
  • ENSP00000292475
  • ENSG00000241468
  • ENST00000359832
  • ENSP00000352890
  • ENST00000394186
  • ENSP00000377740
  • ENST00000414062
  • ENSP00000412149
  • ENST00000488775
  • ENSP00000418197

Symbol
  • ATP5J2
  • ATP5JL
  • ATP5J2
  • ATP5JL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 142.39   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 107   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 142.39   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 107   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (170)
ATP5F1A
Tbio
Family:  Enzyme
Novelty:  0.01052213
Score:  0.999
Data Source:  STRINGDB
ATP5PD
Tbio
Family:  Enzyme
Novelty:  0.0730514
Score:  0.999
Data Source:  STRINGDB
ATP5F1D
Tbio
Family:  Enzyme
Novelty:  0.07296539
Score:  0.999
Data Source:  STRINGDB
ATP5PO
Tbio
Family:  Enzyme
Novelty:  0.01038964
Score:  0.999
Data Source:  STRINGDB
ATP5PB
Tbio
Family:  Enzyme
Novelty:  0.07345384
Score:  0.999
Data Source:  STRINGDB
ATP5PF
Tbio
Family:  Enzyme
Novelty:  0.00585408
Score:  0.999
Data Source:  STRINGDB
ATP5F1B
Tbio
Family:  Enzyme
Novelty:  0.01053177
Score:  0.999
Data Source:  STRINGDB
ATP5F1E
Tbio
Family:  Enzyme
Novelty:  0.01870657
Score:  0.998
Data Source:  STRINGDB
ATP5ME
Tbio
Family:  Enzyme
Novelty:  0.12559724
Score:  0.998
Data Source:  STRINGDB
ATP5MG
Tbio
Family:  Enzyme
Novelty:  0.16555751
Score:  0.994
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (12)
Cristae formation (R-HSA-8949613)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cristae formation
Reactome
Formation of ATP by chemiosmotic coupling
Reactome
Metabolism
Reactome
Mitochondrial biogenesis
Reactome
Organelle biogenesis and maintenance
Name
Explore in Pharos
Explore in Source
Cristae formation
Formation of ATP by chemiosmotic coupling
Metabolism
Mitochondrial biogenesis
Organelle biogenesis and maintenance
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (24)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hormone measurement
2
4
6
95.3
serum metabolite measurement
1
3
3
93
blood metabolite measurement
1
2
3
90.1
dehydroepiandrosterone sulphate measurement
1
5
10
89.6
testosterone measurement
1
1
1
84.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hormone measurement
6
95.3
serum metabolite measurement
3
93
blood metabolite measurement
3
90.1
dehydroepiandrosterone sulphate measurement
10
89.6
testosterone measurement
1
84.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1927558
57423
Rat
RGD:1596067
690441
Dog
ATP synthase subunit f, mitochondrial
102151856
Horse
ATP synthase membrane subunit f
VGNC:15664
100059401
Cow
ATP synthase membrane subunit f
VGNC:26305
506492
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
ATP synthase subunit f, mitochondrial
Horse
ATP synthase membrane subunit f
Cow
ATP synthase membrane subunit f
Publication Statistics
PubMed Score 142.39
PubMed score by year
PubTator Score 1.83
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title