Tbio ATP5IF1 ATPase inhibitor, mitochondrial

Protein Summary

Description

Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP hydrolase. Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by modulating the mitochondrial pH and redox potential, allowing FECH to efficiently catalyze the incorporation of iron into protoporphyrin IX to produce heme. This gene encodes a mitochondrial ATPase inhibitor. Alternative splicing occurs at this locus and three transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9UII2
• Q5JXL8
• Q6IAQ7
• Q9BSL9

Gene Name

• ATP5IF1

Ensembl ID

• ENST00000335514
• ENSP00000335203
• ENSG00000130770
• ENST00000465645
• ENSP00000437337
• ENST00000497986
• ENSP00000435579
• ENST00000642464
• ENSP00000496122
• ENSG00000285390
• ENST00000647074
• ENSP00000494248
• ENST00000647380
• ENSP00000496605

Symbol

• ATPI
• ATPIF1
• IP
• ATPI
• ATPIP
• ATPIF1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0
biological term	0
cell line	0
cell type or tissue	0
cellular component	0

Protein Classes

PANTHER Classes

Protein / Ligase / Atpase Inhibitor, Mitochondrial

DTO Classes

Protein / Enzyme / Ligase / Atpase Inhibitor, Mitochondrial

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 96.27   (req: < 5)

Gene RIFs: 39   (req: <= 3)

Antibodies: 211   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 96.27   (req: >= 5)

Gene RIFs: 39   (req: > 3)

Antibodies: 211   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0