You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
ATP5IF1
ATPase inhibitor, mitochondrial

Protein Summary
Description
Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP hydrolase. Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by modulating the mitochondrial pH and redox potential, allowing FECH to efficiently catalyze the incorporation of iron into protoporphyrin IX to produce heme. This gene encodes a mitochondrial ATPase inhibitor. Alternative splicing occurs at this locus and three transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000335514
  • ENSP00000335203
  • ENSG00000130770
  • ENST00000465645
  • ENSP00000437337
  • ENST00000497986
  • ENSP00000435579
  • ENST00000642464
  • ENSP00000496122
  • ENSG00000285390
  • ENST00000647074
  • ENSP00000494248
  • ENST00000647380
  • ENSP00000496605

Symbol
  • ATPI
  • ATPIF1
  • IP
  • ATPI
  • ATPIP
  • ATPIF1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 79.04   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 211   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 79.04   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 211   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (60)
GUCY2C
Tclin
Family:  Kinase
Novelty:  0.00209733
p_int:  0.991584233
p_ni:  8e-9
p_wrong:  0.008415759
Data Source:  BioPlex
NBR1
Tbio
Novelty:  0.00893066
p_int:  0.987348386
p_ni:  0.012392017
p_wrong:  0.000259598
Data Source:  BioPlex
GPR35
Tchem
Family:  GPCR
Novelty:  0.01188578
p_int:  0.95199191
p_ni:  0.04800809
Score:  0.873
Data Source:  BioPlex,STRINGDB
MTMR9
Tbio
Novelty:  0.09702778
p_int:  0.935073149
p_ni:  0.064926851
Score:  0.175
Data Source:  BioPlex,STRINGDB
ATP5F1C
Tbio
Family:  Enzyme
Novelty:  0.07666564
p_int:  0.930592717
p_ni:  0.069407283
Score:  0.958
Data Source:  BioPlex,STRINGDB
CYTH2
Tbio
Novelty:  0.03560664
p_int:  0.918484527
p_ni:  0.081505979
p_wrong:  0.000009494
Data Source:  BioPlex
ATP5PB
Tbio
Family:  Enzyme
Novelty:  0.07345384
p_int:  0.899183021
p_ni:  0.100816979
Score:  0.782
Data Source:  BioPlex,STRINGDB
NELL2
Tbio
Family:  Enzyme
Novelty:  0.03760438
p_int:  0.826738904
p_ni:  0.173261096
Score:  0.169
Data Source:  BioPlex,STRINGDB
ATP5F1B
Tbio
Family:  Enzyme
Novelty:  0.01053177
p_int:  0.81414674
p_ni:  0.18585326
Score:  0.958
Data Source:  BioPlex,STRINGDB
ZYG11B
Tbio
Novelty:  0.14657862
p_int:  0.781679754
p_ni:  0.218320246
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (26)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Disease Associations (null)
No disease associations found
GWAS Traits (14)
Items per page:
1 – 5 of 14
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
aspartate aminotransferase measurement
1
1
0
7.3
58.4
aspartate aminotransferase measurement
1
1
0
7.3
58.4
hematocrit
2
1
2
47.7
hematocrit
2
1
2
47.7
uric acid measurement
1
1
1
26.6
Items per page:
1 – 5 of 14
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
aspartate aminotransferase measurement
0
7.3
58.4
aspartate aminotransferase measurement
0
7.3
58.4
hematocrit
2
47.7
hematocrit
2
47.7
uric acid measurement
1
26.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ATP synthase inhibitory factor subunit 1
VGNC:449
456682
Macaque
ATP synthase inhibitory factor subunit 1
716870
Mouse
MGI:1196457
11983
Dog
ATP synthase inhibitory factor subunit 1
VGNC:38292
478165
Horse
ATP synthase inhibitory factor subunit 1
VGNC:15691
100056596
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ATP synthase inhibitory factor subunit 1
Macaque
ATP synthase inhibitory factor subunit 1
Mouse
Dog
ATP synthase inhibitory factor subunit 1
Horse
ATP synthase inhibitory factor subunit 1
Publication Statistics
PubMed Score 79.04
PubMed score by year
PubTator Score 212.05
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title