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Tbio
ATP5F1D
ATP synthase subunit delta, mitochondrial

Protein Summary
Description
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP turnover in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000215375
  • ENSP00000215375
  • ENSG00000099624
  • ENST00000395633
  • ENSP00000378995
  • ENST00000591660
  • ENSP00000464863

Symbol
  • ATP5D
  • ATP5D
  • MC5DN5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.66   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 281   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.66   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 281   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (278)
RTN4IP1
Tbio
Family:  Enzyme
Novelty:  0.01274213
p_int:  0.999934679
p_ni:  0.000065182
p_wrong:  1.39e-7
Score:  0.221
Data Source:  BioPlex,STRINGDB
ATP5F1E
Tbio
Family:  Enzyme
Novelty:  0.01870657
p_int:  0.999849808
p_ni:  0.000140055
p_wrong:  0.000010137
Score:  0.999
Data Source:  BioPlex,STRINGDB
FAM172A
Tbio
Novelty:  0.1200899
p_int:  0.999789094
p_ni:  0.000210858
p_wrong:  4.9e-8
Score:  0.177
Data Source:  BioPlex,STRINGDB
AUH
Tbio
Family:  Enzyme
Novelty:  0.01698227
p_int:  0.999497627
p_ni:  0.000257201
p_wrong:  0.000245172
Score:  0.261
Data Source:  BioPlex,STRINGDB
ATP5F1B
Tbio
Family:  Enzyme
Novelty:  0.01053177
p_int:  0.999433331
p_ni:  0.000566669
Score:  0.999
Data Source:  BioPlex,STRINGDB
MTG2
Tbio
Family:  Enzyme
Novelty:  0.06104792
p_int:  0.998965623
p_ni:  0.001034377
Score:  0.364
Data Source:  BioPlex,STRINGDB
MT-ATP8
Tbio
Family:  Enzyme
Novelty:  0.00249065
p_int:  0.995492694
p_ni:  0.004501123
p_wrong:  0.000006183
Score:  0.974
Data Source:  BioPlex,STRINGDB
ATP5F1A
Tbio
Family:  Enzyme
Novelty:  0.01052213
p_int:  0.993776339
p_ni:  0.006223661
Score:  0.999
Data Source:  BioPlex,STRINGDB
ATP5PB
Tbio
Family:  Enzyme
Novelty:  0.07345384
p_int:  0.992176821
p_ni:  0.007823179
Score:  0.999
Data Source:  BioPlex,STRINGDB
CPT2
Tchem
Family:  Enzyme
Novelty:  0.00345645
p_int:  0.989726045
p_ni:  0.010273955
Score:  0.331
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (15)
Cristae formation (R-HSA-8949613)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cristae formation
Reactome
Formation of ATP by chemiosmotic coupling
Reactome
Metabolism
Reactome
Mitochondrial biogenesis
Reactome
Organelle biogenesis and maintenance
Name
Explore in Pharos
Explore in Source
Cristae formation
Formation of ATP by chemiosmotic coupling
Metabolism
Mitochondrial biogenesis
Organelle biogenesis and maintenance
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
5
8
98.1
reticulocyte measurement
3
3
3
94.2
reticulocyte count
7
2
7
91.4
lymphocyte count
1
5
5
91.1
lymphocyte percentage of leukocytes
1
2
2
85.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
8
98.1
reticulocyte measurement
3
94.2
reticulocyte count
7
91.4
lymphocyte count
5
91.1
lymphocyte percentage of leukocytes
2
85.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ATP synthase F1 subunit delta
742197
Mouse
MGI:1913293
66043
Rat
RGD:621372
245965
Dog
ATP synthase F1 subunit delta
VGNC:38264
476756
Horse
ATP synthase F1 subunit delta [Source:HGNC Symbol;Acc:HGNC:837]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ATP synthase F1 subunit delta
Mouse
Rat
Dog
ATP synthase F1 subunit delta
Horse
ATP synthase F1 subunit delta [Source:HGNC Symbol;Acc:HGNC:837]
Publication Statistics
PubMed Score 12.66
PubMed score by year
PubTator Score 2.48
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title