Tbio ATP5F1D ATP synthase subunit delta, mitochondrial

Protein Summary

Description

Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP turnover in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the delta subunit of the catalytic core. Alternatively spliced transcript variants encoding the same isoform have been identified. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P30049
• D6W5Y3
• Q6FG90

Gene Name

• ATP5F1D

Ensembl ID

• ENST00000215375
• ENSP00000215375
• ENSG00000099624
• ENST00000395633
• ENSP00000378995
• ENST00000591660
• ENSP00000464863

Symbol

• ATP5D
• ATP5D
• MC5DN5

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0
biological term	0
cell line	0
cell type or tissue	0
cellular component	0

Protein Classes

PANTHER Classes

Protein / Transporter / Cation Transporter / Atp Synthase / Atp Synthase Subunit Delta, Mitochondrial

Protein / Hydrolase / Atp Synthase Subunit Delta, Mitochondrial

DTO Classes

Protein / Transporter / F-type And V-type Atpases / F-type Atpase / Atp Synthase Subunit Delta, Mitochondrial

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.66   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 281   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.66   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 281   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GlyGen

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (278)

Explore Interacting Targets

1 – 10 of 278

• See Interactions on String-DB

RTN4IP1

Tbio

Family:  Enzyme

Novelty:  0.01274213

p_int:  0.999934679

p_ni:  0.000065182

p_wrong:  1.39e-7

Score:  0.221

Data Source:  BioPlex,STRINGDB

ATP5F1E

Tbio

Family:  Enzyme

Novelty:  0.01870657

p_int:  0.999849808

p_ni:  0.000140055

p_wrong:  0.000010137

Score:  0.999

Data Source:  BioPlex,STRINGDB

FAM172A

Tbio

Novelty:  0.1200899

p_int:  0.999789094

p_ni:  0.000210858

p_wrong:  4.9e-8

Score:  0.177

Data Source:  BioPlex,STRINGDB

AUH

Tbio

Family:  Enzyme

Novelty:  0.01698227

p_int:  0.999497627

p_ni:  0.000257201

p_wrong:  0.000245172

Score:  0.261

Data Source:  BioPlex,STRINGDB

ATP5F1B

Tbio

Family:  Enzyme

Novelty:  0.01053177

p_int:  0.999433331

p_ni:  0.000566669

Score:  0.999

Data Source:  BioPlex,STRINGDB

MTG2

Tbio

Family:  Enzyme

Novelty:  0.06104792

p_int:  0.998965623

p_ni:  0.001034377

Score:  0.364

Data Source:  BioPlex,STRINGDB

MT-ATP8

Tbio

Family:  Enzyme

Novelty:  0.00249065

p_int:  0.995492694

p_ni:  0.004501123

p_wrong:  0.000006183

Score:  0.974

Data Source:  BioPlex,STRINGDB

ATP5F1A

Tbio

Family:  Enzyme

Novelty:  0.01052213

p_int:  0.993776339

p_ni:  0.006223661

Score:  0.999

Data Source:  BioPlex,STRINGDB

ATP5PB

Tbio

Family:  Enzyme

Novelty:  0.07345384

p_int:  0.992176821

p_ni:  0.007823179

Score:  0.999

Data Source:  BioPlex,STRINGDB

CPT2

Tchem

Family:  Enzyme

Novelty:  0.00345645

p_int:  0.989726045

p_ni:  0.010273955

Score:  0.331

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (15)

Reactome (7)

KEGG (6)

WikiPathways (2)

Cristae formation (R-HSA-8949613)

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5

1 – 5 of 7

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cristae formation	28 targets	R-HSA-8949613
Reactome	Formation of ATP by chemiosmotic coupling	17 targets	R-HSA-163210
Reactome	Metabolism	2112 targets	R-HSA-1430728
Reactome	Mitochondrial biogenesis	89 targets	R-HSA-1592230
Reactome	Organelle biogenesis and maintenance	276 targets	R-HSA-1852241

Name	Explore in Pharos	Explore in Source
Cristae formation	28 targets	R-HSA-8949613
Formation of ATP by chemiosmotic coupling	17 targets	R-HSA-163210
Metabolism	2112 targets	R-HSA-1430728
Mitochondrial biogenesis	89 targets	R-HSA-1592230
Organelle biogenesis and maintenance	276 targets	R-HSA-1852241

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (15)

Functions (4)

Components (5)

Processes (6)

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Items per page:

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1 – 4 of 4

GO Term	Evidence	Assigned by
ATPase activity	Non-traceable Author Statement (NAS)	UniProtKB
transporter activity	Non-traceable Author Statement (NAS)	UniProtKB
transmembrane transporter activity	Inferred by Curator (IC)	UniProtKB
proton-transporting ATP synthase activity, rotational mechanism	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations ()

No disease associations found

GWAS Traits (20)

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5

1 – 5 of 20

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
heel bone mineral density	EFO_0009270	3	5	8		98.1
reticulocyte measurement	EFO_0010700	3	3	3		94.2
reticulocyte count	EFO_0007986	7	2	7		91.4
lymphocyte count	EFO_0004587	1	5	5		91.1
lymphocyte percentage of leukocytes	EFO_0007993	1	2	2		85.5

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 20

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
heel bone mineral density	EFO_0009270	8		98.1
reticulocyte measurement	EFO_0010700	3		94.2
reticulocyte count	EFO_0007986	7		91.4
lymphocyte count	EFO_0004587	5		91.1
lymphocyte percentage of leukocytes	EFO_0007993	2		85.5

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Acetylation
ATP synthesis
CF(1)
Complete proteome
Direct protein sequencing
Hydrogen ion transport
Ion transport
Membrane
Mitochondrion
Mitochondrion inner membrane

GWAS Trait Find Similar Targets

No Header	No Header
balding measurement
childhood onset asthma
colorectal cancer
creatinine measurement
eosinophil percentage of leukocytes
heel bone mineral density
hematocrit
hemoglobin measurement
lymphocyte count
lymphocyte percentage of leukocytes

IDG Resources

No IDG generated resources found

Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	ATP synthase F1 subunit delta		742197
Mouse	ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit	MGI:1913293	66043
Rat	ATP synthase F1 subunit delta	RGD:621372	245965
Dog	ATP synthase F1 subunit delta	VGNC:38264	476756
Horse	ATP synthase F1 subunit delta [Source:HGNC Symbol;Acc:HGNC:837]

Species	Name	OMA	EggNOG	Inparanoid
Chimp	ATP synthase F1 subunit delta
Mouse	ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit
Rat	ATP synthase F1 subunit delta
Dog	ATP synthase F1 subunit delta
Horse	ATP synthase F1 subunit delta [Source:HGNC Symbol;Acc:HGNC:837]

Publication Statistics

PubMed Score 12.66

PubMed score by year

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PubTator Score 2.48

PubTator score by year

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Related Publications

Text Mined References (18)

GeneRif Annotations (3)

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10

0 of 0

PMID	Year	Title