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Tbio
ATP5F1A
ATP synthase subunit alpha, mitochondrial

Protein Summary
Description
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. Subunit alpha does not bear the catalytic high-affinity ATP-binding sites (By similarity). Binds the bacterial siderophore enterobactin and can promote mitochondrial accumulation of en ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000282050
  • ENSP00000282050
  • ENSG00000152234
  • ENST00000398752
  • ENSP00000381736
  • ENST00000590665
  • ENSP00000467037
  • ENST00000593152
  • ENSP00000465477

Symbol
  • ATP5A
  • ATP5A1
  • ATP5AL2
  • ATPM
  • OMR
  • ORM
  • ATPM
  • MOM2
  • ATP5A
  • hATP1
  • ATP5A1
  • MC5DN4
  • ATP5AL2
  • COXPD22
  • HEL-S-123m
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 126.65   (req: < 5)
Gene RIFs: 31   (req: <= 3)
Antibodies: 291   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 126.65   (req: >= 5)
Gene RIFs: 31   (req: > 3)
Antibodies: 291   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0