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Tbio
ATP5F1A
ATP synthase subunit alpha, mitochondrial

Protein Summary
Description
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. Subunit alpha does not bear the catalytic high-affinity ATP-binding sites (By similarity). Binds the bacterial siderophore enterobactin and can promote mitochondrial accumulation of en ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000282050
  • ENSP00000282050
  • ENSG00000152234
  • ENST00000398752
  • ENSP00000381736
  • ENST00000590665
  • ENSP00000467037
  • ENST00000593152
  • ENSP00000465477

Symbol
  • ATP5A
  • ATP5A1
  • ATP5AL2
  • ATPM
  • OMR
  • ORM
  • ATPM
  • MOM2
  • ATP5A
  • hATP1
  • ATP5A1
  • MC5DN4
  • ATP5AL2
  • COXPD22
  • HEL-S-123m
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.36   (req: < 5)
Gene RIFs: 31   (req: <= 3)
Antibodies: 291   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.36   (req: >= 5)
Gene RIFs: 31   (req: > 3)
Antibodies: 291   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (461)
ATP5PF
Tbio
Family:  Enzyme
Novelty:  0.00585408
p_int:  0.999353409
p_ni:  0.000646591
Score:  0.994
Data Source:  BioPlex,STRINGDB
ATP5F1B
Tbio
Family:  Enzyme
Novelty:  0.01053177
p_int:  0.996480504
p_ni:  0.003519496
Score:  0.999
Data Source:  BioPlex,STRINGDB
ATP5F1D
Tbio
Family:  Enzyme
Novelty:  0.07296539
p_int:  0.993776339
p_ni:  0.006223661
Score:  0.999
Data Source:  BioPlex,STRINGDB
ATP5PB
Tbio
Family:  Enzyme
Novelty:  0.07345384
p_int:  0.990239151
p_ni:  0.009760849
Score:  0.999
Data Source:  BioPlex,STRINGDB
ZFYVE27
Tbio
Novelty:  0.0563358
p_int:  0.976628661
p_ni:  0.023371339
Score:  0.686
Data Source:  BioPlex,STRINGDB
ACKR3
Tchem
Family:  GPCR
Novelty:  0.00727792
p_int:  0.961768613
p_ni:  0.038231387
Score:  0.847
Data Source:  BioPlex,STRINGDB
VIPR2
Tchem
Family:  GPCR
Novelty:  0.00463802
p_int:  0.773325688
p_ni:  0.226674312
Data Source:  BioPlex
ATP5F1C
Tbio
Family:  Enzyme
Novelty:  0.07666564
Score:  0.999
Data Source:  STRINGDB
ATP5PD
Tbio
Family:  Enzyme
Novelty:  0.0730514
Score:  0.999
Data Source:  STRINGDB
ATP5MF
Tbio
Family:  Enzyme
Novelty:  0.00707678
Score:  0.999
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (17)
Cristae formation (R-HSA-8949613)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cristae formation
Reactome
Formation of ATP by chemiosmotic coupling
Reactome
Metabolism
Reactome
Mitochondrial biogenesis
Reactome
Mitochondrial protein import
Name
Explore in Pharos
Explore in Source
Cristae formation
Formation of ATP by chemiosmotic coupling
Metabolism
Mitochondrial biogenesis
Mitochondrial protein import
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (27)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Mutant Phenotype (IMP)
CAFA
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred by Curator (IC)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
3
3
98.1
reticulocyte count
2
1
2
82.5
reticulocyte measurement
1
1
1
78.6
HbA1c measurement
1
1
1
21.5
mean corpuscular hemoglobin concentration
1
1
1
11.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
3
98.1
reticulocyte count
2
82.5
reticulocyte measurement
1
78.6
HbA1c measurement
1
21.5
mean corpuscular hemoglobin concentration
1
11.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ATP synthase F1 subunit alpha
VGNC:49013
455397
Macaque
ATP synthase F1 subunit alpha
701389
Mouse
MGI:88115
11946
Dog
ATP synthase F1 subunit alpha
VGNC:53332
480149
Horse
ATP synthase F1 subunit alpha
VGNC:15659
100053178
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ATP synthase F1 subunit alpha
Macaque
ATP synthase F1 subunit alpha
Mouse
Dog
ATP synthase F1 subunit alpha
Horse
ATP synthase F1 subunit alpha
Publication Statistics
PubMed Score 91.36
PubMed score by year
PubTator Score 57.59
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title