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Tbio
ATP2B2
Plasma membrane calcium-transporting ATPase 2

Protein Summary
Description
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell. The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 2. Alternatively splic ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360273
  • ENSP00000353414
  • ENSG00000157087
  • ENST00000383800
  • ENSP00000373311
  • ENST00000397077
  • ENSP00000380267
  • ENST00000452124
  • ENSP00000414854
  • ENST00000460129
  • ENSP00000424494
  • ENST00000643662
  • ENSP00000495924
  • ENST00000644807
  • ENSP00000495228
  • ENST00000645850
  • ENSP00000494716
  • ENST00000646379
  • ENSP00000494381

Symbol
  • PMCA2
  • PMCA2
  • PMCA2a
  • PMCA2i
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
protein domain
1
co-expressed gene
0.95
biological process
0.89
trait
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 139.81   (req: < 5)
Gene RIFs: 30   (req: <= 3)
Antibodies: 115   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 139.81   (req: >= 5)
Gene RIFs: 30   (req: > 3)
Antibodies: 115   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (314)
MAOB
Tclin
Family:  Enzyme
Novelty:  0.00030366
p_int:  0.999999943
p_ni:  5.6e-8
p_wrong:  1e-9
Score:  0.242
Data Source:  BioPlex,STRINGDB
ATP2B3
Tbio
Family:  Transporter
Novelty:  0.00901493
p_int:  0.999999896
p_ni:  1.04e-7
Score:  0.578
Data Source:  BioPlex,STRINGDB
GPAM
Tbio
Family:  Enzyme
Novelty:  0.00973127
p_int:  0.999998645
p_ni:  5.51e-7
p_wrong:  8.03e-7
Score:  0.158
Data Source:  BioPlex,STRINGDB
NRM
Tbio
Novelty:  0.02136368
p_int:  0.999997426
p_ni:  0.000002041
p_wrong:  5.32e-7
Data Source:  BioPlex
FAM174A
Tdark
Novelty:  0.30693139
p_int:  0.999990458
p_ni:  0.000009542
Data Source:  BioPlex
ABCD1
Tbio
Family:  Transporter
Novelty:  0.0067013
p_int:  0.99998463
p_ni:  0.00001537
Score:  0.242
Data Source:  BioPlex,STRINGDB
TMEM168
Tdark
Novelty:  0.89372034
p_int:  0.999981873
p_ni:  1.74e-7
p_wrong:  0.000017953
Score:  0.516
Data Source:  BioPlex,STRINGDB
ATP2B4
Tbio
Family:  Transporter
Novelty:  0.00560356
p_int:  0.999981125
p_ni:  0.000018875
Score:  0.183
Data Source:  BioPlex,STRINGDB
DGAT1
Tclin
Family:  Enzyme
Novelty:  0.00121009
p_int:  0.999979766
p_ni:  0.000020234
Score:  0.196
Data Source:  BioPlex,STRINGDB
APOD
Tbio
Novelty:  0.0031899
p_int:  0.999964102
p_ni:  0.000035898
Score:  0.237
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (18)
Cardiac conduction (R-HSA-5576891)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cardiac conduction
Reactome
Hemostasis
Reactome
Ion channel transport
Reactome
Ion homeostasis
Reactome
Ion transport by P-type ATPases
Name
Explore in Pharos
Explore in Source
Cardiac conduction
Hemostasis
Ion channel transport
Ion homeostasis
Ion transport by P-type ATPases
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (25)
Find Similar Targets
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
SynGO
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
SynGO
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
3
2
3
86.1
insomnia measurement
1
2
0
1
59.4
waist-hip ratio
1
1
1
49.5
BMI-adjusted waist-hip ratio
1
1
1
46.9
self reported educational attainment
1
1
1
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
3
86.1
insomnia measurement
0
1
59.4
waist-hip ratio
1
49.5
BMI-adjusted waist-hip ratio
1
46.9
self reported educational attainment
1
31.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ATPase plasma membrane Ca2+ transporting 2
VGNC:11332
460168
Macaque
ATPase plasma membrane Ca2+ transporting 2
701149
Mouse
MGI:105368
11941
Rat
RGD:2176
24215
Dog
ATPase plasma membrane Ca2+ transporting 2
VGNC:38257
476535
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ATPase plasma membrane Ca2+ transporting 2
Macaque
ATPase plasma membrane Ca2+ transporting 2
Mouse
Rat
Dog
ATPase plasma membrane Ca2+ transporting 2
Publication Statistics
PubMed Score 139.81
PubMed score by year
PubTator Score 256.84
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title