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Tdark
ATP1B4
Protein ATP1B4

Protein Summary
Description
May act as a transcriptional coregulator during muscle development through its interaction with SNW1. Has lost its ancestral function as a Na,K-ATPase beta-subunit. This gene has been found in all vertebrate genomes sequenced to date. However, this gene has undergone a change in function in placental mammals compared to other species. Specifically, in fish, avian, and amphibian species, this gene encodes plasma membrane-bound beta-subunits of Na,K-ATPase. In placental mammals, the encoded protein interacts with the nuclear transcriptional coregulator SKIP and may be involved in the regulation of TGF-beta signaling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000218008
  • ENSP00000218008
  • ENSG00000101892
  • ENST00000361319
  • ENSP00000355346
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.76
gene perturbation
0.61
virus perturbation
0.59
tissue
0.55
cellular component
0.53


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.05   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 46   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.05   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 46   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (70)
ATP1A4
Tclin
Family:  Transporter
Novelty:  0.01011201
p_int:  0.999998674
p_ni:  0.000001325
p_wrong:  1e-9
Score:  0.941
Data Source:  BioPlex,STRINGDB
TMEM8A
Tdark
Novelty:  0.15724279
p_int:  0.999944013
p_ni:  0.000055981
p_wrong:  6e-9
Score:  0.795
Data Source:  BioPlex,STRINGDB
TMEM67
Tbio
Novelty:  0.02573267
p_int:  0.999464078
p_ni:  0.000535922
Data Source:  BioPlex
TGFBR3
Tbio
Novelty:  0.0077307
p_int:  0.998818045
p_ni:  0.00118194
p_wrong:  1.5e-8
Data Source:  BioPlex
TMEM59L
Tbio
Novelty:  0.22745646
p_int:  0.996610207
p_ni:  0.003260645
p_wrong:  0.000129148
Score:  0.183
Data Source:  BioPlex,STRINGDB
ENTPD7
Tbio
Family:  Enzyme
Novelty:  0.1810079
p_int:  0.991359368
p_ni:  0.008070139
p_wrong:  0.000570492
Data Source:  BioPlex
FCGRT
Tclin
Novelty:  0.00105713
p_int:  0.977432654
p_ni:  0.02199594
p_wrong:  0.000571406
Data Source:  BioPlex
BTN2A2
Tdark
Novelty:  0.46565474
p_int:  0.973600798
p_ni:  0.026399187
p_wrong:  1.5e-8
Data Source:  BioPlex
RTN2
Tbio
Novelty:  0.05184418
p_int:  0.970198155
p_ni:  0.029801794
p_wrong:  5.1e-8
Data Source:  BioPlex
ITGA7
Tbio
Novelty:  0.01243073
p_int:  0.926459351
p_ni:  0.073540649
Score:  0.155
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets (3)
Explore Nearest Tclin Targets
Pathways (26)
Gene expression (Transcription) (R-HSA-74160)

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Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Reactome
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Signal Transduction
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
leukocyte count
1
1
1
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
leukocyte count
1
35
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ATPase Na+/K+ transporting family member beta 4
VGNC:12193
738390
Macaque
ATPase Na+/K+ transporting family member beta 4
696160
Mouse
MGI:1915071
67821
Rat
RGD:620994
84396
Dog
ATPase Na+/K+ transporting family member beta 4
VGNC:38251
481036
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ATPase Na+/K+ transporting family member beta 4
Macaque
ATPase Na+/K+ transporting family member beta 4
Mouse
Rat
Dog
ATPase Na+/K+ transporting family member beta 4
Publication Statistics
PubMed Score 11.05
PubMed score by year
PubTator Score 10.06
PubTator score by year
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Related Publications
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PMID
Year
Title