Tclin ATP1B1 Sodium/potassium-transporting ATPase subunit beta-1

Protein Summary

Description

This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. Involved in cell adhesion and establishing epithelial cell polarity. The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 1 subunit. Alternatively spliced transcript variants encoding different isoforms have been described, but their biological validity is not known. [provided by RefSeq, Mar 2010]

Uniprot Accession IDs

• P05026
• Q5TGZ3

Gene Name

• ATP1B1

Ensembl ID

• ENST00000367815
• ENSP00000356789
• ENSG00000143153
• ENST00000367816
• ENSP00000356790

Symbol

• ATP1B
• ATP1B

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	1
transcription factor perturbation	1
biological process	0.98
PubMedID	0.98
virus perturbation	0.95

Protein Classes

PANTHER Classes

Protein / Transporter / Cation Transporter / Sodium/potassium-transporting Atpase Subunit Beta-1

DTO Classes

Protein / Transporter / P-type Atpases / Na+/k+-atpases / Sodium/potassium-transporting Atpase Subunit Beta-1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.03   (req: < 5)

Gene RIFs: 44   (req: <= 3)

Antibodies: 294   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.03   (req: >= 5)

Gene RIFs: 44   (req: > 3)

Antibodies: 294   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3