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Tclin
ATP1B1
Sodium/potassium-transporting ATPase subunit beta-1

Protein Summary
Description
This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. Involved in cell adhesion and establishing epithelial cell polarity. The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta su ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367815
  • ENSP00000356789
  • ENSG00000143153
  • ENST00000367816
  • ENSP00000356790

Symbol
  • ATP1B
  • ATP1B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
transcription factor perturbation
1
biological process
0.98
PubMedID
0.98
virus perturbation
0.95


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.7   (req: < 5)
Gene RIFs: 36   (req: <= 3)
Antibodies: 294   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.7   (req: >= 5)
Gene RIFs: 36   (req: > 3)
Antibodies: 294   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (122)
ATP1A1
Tclin
Family:  Transporter
Novelty:  0.01078788
Score:  0.997
Data Source:  Reactome,STRINGDB
ATP1A4
Tclin
Family:  Transporter
Novelty:  0.01011201
Score:  0.991
Data Source:  Reactome,STRINGDB
ATP1A2
Tclin
Family:  Transporter
Novelty:  0.00606202
Score:  0.991
Data Source:  Reactome,STRINGDB
ATP1A3
Tclin
Family:  Transporter
Novelty:  0.00485594
Score:  0.99
Data Source:  Reactome,STRINGDB
FXYD2
Tclin
Family:  Enzyme
Novelty:  0.0196518
Score:  0.989
Data Source:  STRINGDB
FXYD7
Tbio
Family:  IC
Novelty:  0.08820333
Score:  0.983
Data Source:  STRINGDB
NKAIN4
Tdark
Family:  Enzyme
Novelty:  1.65380282
Score:  0.954
Data Source:  STRINGDB
ATP12A
Tchem
Family:  Transporter
Novelty:  0.00008793
Score:  0.935
Data Source:  STRINGDB
FXYD1
Tbio
Family:  IC
Novelty:  0.00421639
Score:  0.931
Data Source:  STRINGDB
ATP2A2
Tchem
Family:  Transporter
Novelty:  0.00133604
Score:  0.929
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (28)
Basigin interactions (R-HSA-210991)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Basigin interactions
Reactome
Cardiac conduction
Reactome
Cell surface interactions at the vascular wall
Reactome
Hemostasis
Reactome
Ion channel transport
Name
Explore in Pharos
Explore in Source
Basigin interactions
Cardiac conduction
Cell surface interactions at the vascular wall
Hemostasis
Ion channel transport
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (41)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
1
2
95.6
QT interval
5
9
0
2.2
89.1
electrocardiography
1
2
27
78.7
3
2
3
69.1
intraocular pressure measurement
2
2
2
52.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
2
95.6
QT interval
0
2.2
89.1
electrocardiography
27
78.7
3
69.1
intraocular pressure measurement
2
52.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ATPase Na+/K+ transporting subunit beta 1
VGNC:8031
457497
Macaque
ATPase Na+/K+ transporting subunit beta 1
700443
Mouse
MGI:88108
11931
Rat
RGD:2170
25650
Dog
ATPase Na+/K+ transporting subunit beta 1
VGNC:38248
403966
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ATPase Na+/K+ transporting subunit beta 1
Macaque
ATPase Na+/K+ transporting subunit beta 1
Mouse
Rat
Dog
ATPase Na+/K+ transporting subunit beta 1
Publication Statistics
PubMed Score 37.70
PubMed score by year
PubTator Score 307.33
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title