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Tclin
ATP1A4
Sodium/potassium-transporting ATPase subunit alpha-4

Protein Summary
Description
This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. Plays a role in sperm motility. The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded b ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368081
  • ENSP00000357060
  • ENSG00000132681
  • ENST00000470705
  • ENSP00000433094

Symbol
  • ATP1AL2
  • ATP1A1
  • ATP1AL2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
protein domain
0.99
tissue sample
0.63
gene perturbation
0.62
interacting protein
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 99.37   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 9   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 99.37   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 9   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (97)
P2RY8
Tbio
Family:  GPCR
Novelty:  0.05574297
p_int:  0.999999928
p_ni:  6.8e-8
p_wrong:  4e-9
Score:  0.17
Data Source:  BioPlex,STRINGDB
CHRM3
Tclin
Family:  GPCR
Novelty:  0.00849776
p_int:  0.999999788
p_ni:  3.9e-8
p_wrong:  1.73e-7
Data Source:  BioPlex
ATP1B4
Tdark
Family:  Transporter
Novelty:  0.08212894
p_int:  0.999998674
p_ni:  0.000001325
p_wrong:  1e-9
Score:  0.941
Data Source:  BioPlex,STRINGDB
HIST1H4A
Tchem
Novelty:  0.00279614
p_int:  0.999997915
p_ni:  0.00000205
p_wrong:  3.5e-8
Data Source:  BioPlex
KLHL9
Tdark
Novelty:  0.22434722
p_int:  0.999997517
p_ni:  0.000002256
p_wrong:  2.27e-7
Data Source:  BioPlex
RPGR
Tbio
Family:  Enzyme
Novelty:  0.002733
p_int:  0.999986817
p_ni:  0.00001316
p_wrong:  2.4e-8
Score:  0.296
Data Source:  BioPlex,STRINGDB
LRRCC1
Tdark
Novelty:  0.14730953
p_int:  0.999963133
p_ni:  0.000035953
p_wrong:  9.14e-7
Score:  0.206
Data Source:  BioPlex,STRINGDB
ATP1B1
Tclin
Family:  Transporter
Novelty:  0.025056
Score:  0.991
Data Source:  Reactome,STRINGDB
FXYD2
Tclin
Family:  Enzyme
Novelty:  0.0196518
Score:  0.98
Data Source:  STRINGDB
ATP1B2
Tclin
Family:  Transporter
Novelty:  0.02641193
Score:  0.973
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (25)
Cardiac conduction (R-HSA-5576891)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cardiac conduction
Reactome
Ion channel transport
Reactome
Ion homeostasis
Reactome
Ion transport by P-type ATPases
Reactome
Muscle contraction
Name
Explore in Pharos
Explore in Source
Cardiac conduction
Ion channel transport
Ion homeostasis
Ion transport by P-type ATPases
Muscle contraction
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
granulocyte count
1
2
2
81.8
electrocardiography
1
1
3
26.1
FEV/FEC ratio
1
1
1
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
granulocyte count
2
81.8
electrocardiography
3
26.1
FEV/FEC ratio
1
17.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ATPase Na+/K+ transporting subunit alpha 4
VGNC:8030
458010
Mouse
MGI:1351335
27222
Rat
RGD:61952
29132
Dog
ATPase Na+/K+ transporting subunit alpha 4
VGNC:38247
488636
Horse
ATPase Na+/K+ transporting subunit alpha 4
VGNC:15645
100058301
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ATPase Na+/K+ transporting subunit alpha 4
Mouse
Rat
Dog
ATPase Na+/K+ transporting subunit alpha 4
Horse
ATPase Na+/K+ transporting subunit alpha 4
Publication Statistics
PubMed Score 99.37
PubMed score by year
PubTator Score 6.13
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title