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Tclin
ATP1A3
Sodium/potassium-transporting ATPase subunit alpha-3

Protein Summary
Description
This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene enco ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302102
  • ENSP00000302397
  • ENSG00000105409
  • ENST00000543770
  • ENSP00000437577
  • ENST00000545399
  • ENSP00000444688
  • ENST00000648268
  • ENSP00000498113

Symbol
  • RDP
  • AHC2
  • CAPOS
  • DYT12
  • ATP1A1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
protein domain
0.99
phenotype
0.72
biological process
0.69
PubMedID
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 241.48   (req: < 5)
Gene RIFs: 54   (req: <= 3)
Antibodies: 178   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 241.48   (req: >= 5)
Gene RIFs: 54   (req: > 3)
Antibodies: 178   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (128)
FXYD6
Tbio
Family:  IC
Novelty:  0.0503209
p_int:  0.891499111
p_ni:  0.108500889
Score:  0.931
Data Source:  BioPlex,STRINGDB
SPPL2B
Tchem
Family:  Enzyme
Novelty:  0.0274774
p_int:  0.877885894
p_ni:  0.122114106
Score:  0.158
Data Source:  BioPlex,STRINGDB
S1PR1
Tclin
Family:  GPCR
Novelty:  0.00162513
p_int:  0.811676405
p_ni:  0.188323595
Score:  0.264
Data Source:  BioPlex,STRINGDB
MGARP
Tbio
Novelty:  0.02883753
p_int:  0.809117075
p_ni:  0.190882925
Data Source:  BioPlex
OPALIN
Tdark
Novelty:  0.08221612
p_int:  0.784386245
p_ni:  0.215613755
Score:  0.362
Data Source:  BioPlex,STRINGDB
LRRN2
Tdark
Novelty:  0.22583761
p_int:  0.784350996
p_ni:  0.215649004
Score:  0.293
Data Source:  BioPlex,STRINGDB
ATP1B3
Tclin
Family:  Transporter
Novelty:  0.06773518
Score:  0.994
Data Source:  Reactome,STRINGDB
ATP1B1
Tclin
Family:  Transporter
Novelty:  0.025056
Score:  0.99
Data Source:  Reactome,STRINGDB
ATP1B2
Tclin
Family:  Transporter
Novelty:  0.02641193
Score:  0.978
Data Source:  Reactome,STRINGDB
FXYD2
Tclin
Family:  Enzyme
Novelty:  0.0196518
Score:  0.97
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (26)
Cardiac conduction (R-HSA-5576891)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cardiac conduction
Reactome
Ion channel transport
Reactome
Ion homeostasis
Reactome
Ion transport by P-type ATPases
Reactome
Muscle contraction
Name
Explore in Pharos
Explore in Source
Cardiac conduction
Ion channel transport
Ion homeostasis
Ion transport by P-type ATPases
Muscle contraction
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (29)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
SynGO
Inferred from Direct Assay (IDA)
ARUK-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Non-traceable Author Statement (NAS)
UniProtKB
Non-traceable Author Statement (NAS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
1
2
53.3
low density lipoprotein cholesterol measurement
1
1
1
50.6
alkaline phosphatase measurement
1
1
1
42.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
53.3
low density lipoprotein cholesterol measurement
1
50.6
alkaline phosphatase measurement
1
42.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
ATPase Na+/K+ transporting subunit alpha 3
706513
Mouse
MGI:88107
232975
Rat
RGD:2169
24213
Dog
ATPase Na+/K+ transporting subunit alpha 3
VGNC:38246
612463
Horse
ATPase Na+/K+ transporting subunit alpha 3
VGNC:15644
100069796
Species
Name
OMA
EggNOG
Inparanoid
Macaque
ATPase Na+/K+ transporting subunit alpha 3
Mouse
Rat
Dog
ATPase Na+/K+ transporting subunit alpha 3
Horse
ATPase Na+/K+ transporting subunit alpha 3
Publication Statistics
PubMed Score 241.48
PubMed score by year
PubTator Score 140.54
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title